Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination

• Published in: Cancer biology & therapy Vol. 10; no. 12; pp. 1266 - 1279
• Main Authors: Noguchi, Masanori, Mine, Takashi, Komatsu, Nobukazu, Suekane, Shigetaka, Moriya, Fukuko, Matsuoka, Kei, Yutani, Shigeru, Shichijo, Shigeki, Yamada, Akira, Toh, Uhi, Kawano, Kouichiro, Azuma, Kouichi, Uemura, Hirotsugu, Okuno, Kiyotaka, Matsumoto, Kazumasa, Yanagimoto, Hiroaki, Yamanaka, Ryuya, Oka, Masaaki, Todo, Satoru, Sasada, Tetsuro, Itoh, Kyogo
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 15.12.2010
• Subjects: Adult; Aged; Antigens, Surface; Binding; Biology; Biomarkers; Bioscience; Calcium; Cancer; Cancer Vaccines - immunology; Cancer Vaccines - therapeutic use; Cell; Cycle; Female; Humans; Immunoglobulin G - blood; Immunoglobulin G - immunology; Landes; Lymphocyte Count; Male; Middle Aged; Neoplasms - immunology; Neoplasms - mortality; Neoplasms - therapy; Organogenesis; Precision Medicine; Prognosis; Prostate-Specific Antigen - immunology; Prostatic Neoplasms - immunology; Prostatic Neoplasms - therapy; Proteins; Survival Rate; T-Lymphocytes, Cytotoxic - immunology; Vaccines, Subunit - immunology; Vaccines, Subunit - therapeutic use

To investigate immunological biomarkers to predict overall survival of advanced cancer patients under treatment with personalized peptide vaccination, correlations between overall survival and biomarkers, including cytotoxic T lymphocyte (CTL) and immunoglobulin G (IgG) responses to the vaccinated p...