Overexpression of Long Noncoding RNA H19 Downregulates miR-140-5p and Activates PI3K/AKT Signaling Pathway to Promote Invasion, Migration and Epithelial-Mesenchymal Transition of Ovarian Cancer Cells

• Published in: BioMed research international Vol. 2021; no. 1; p. 6619730
• Main Authors: Xu, Hao, Ding, Yuan, Yang, Xiangying
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animals; Apoptosis; Base Sequence; Biomedical research; Cancer; Carcinogenesis - genetics; Carcinogenesis - pathology; Cell activation; Cell differentiation; Cell Line, Tumor; Cell Movement - genetics; Cell proliferation; Cellular signal transduction; Development and progression; Down-Regulation - genetics; Epithelial cells; Epithelial-Mesenchymal Transition - genetics; Epithelium; Experiments; Female; Flow cytometry; Gene Expression Regulation, Neoplastic; Genetic aspects; Health aspects; Humans; Medical prognosis; Mesenchyme; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Neoplasm Invasiveness; Oncology, Experimental; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Phosphatidylinositol 3-Kinases - metabolism; Protein kinases; Proteins; Proto-Oncogene Proteins c-akt - metabolism; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Signal Transduction; Signaling; Stem cells; Transfection; Tumors; China

Objective. The abnormal expression of LncRNA H19 and miR-140-5p has been linked to ovarian cancer (OC). Whether H19 directly regulates miR-140-5p in ovarian cancer cells has been unclear. In this study, we deeply explored the relationship between H19 and miR-140-5p in ovarian cancer and the mechanis...