Acute coagulopathy of trauma: Balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation

• Published in: Medical hypotheses Vol. 75; no. 6; pp. 564 - 567
• Main Authors: Johansson, P.I, Ostrowski, S.R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.12.2010
• Subjects: Blood Coagulation Disorders - etiology; Blood Coagulation Disorders - physiopathology; Catecholamines - blood; Endothelium - metabolism; Hemostasis - physiology; Humans; Internal Medicine; Thrombelastography; Wounds and Injuries - complications; Wounds and Injuries - pathology

Summary Acute coagulopathy of trauma predicts a poor clinical outcome. Tissue trauma activates the sympathoadrenal system resulting in high circulating levels of catecholamines that influence hemostasis dose-dependently through immediate effects on the two major compartments of hemostasis, i.e., the...