Development of screening method for intranasal influenza vaccine and adjuvant safety in preclinical study - Hiradate, Yuki; Sasaki, Eita; Momose, Haruka; Asanuma, Hideki; Furuhata, Keiko; Takai, Mamiko; Aoshi, Taiki; Yamada, Hiroshi; Ishii, Ken J.; Tanemura, Kentaro; Mizukami, Takuo; Hamaguchi, Isao (Biologicals, 2018)
Keywords: Adjuvant; Adjuvants, Immunologic - chemistry; Adjuvants, Immunologic - pharmacology; Administration, Intranasal; Alum; Animals; Biomarkers; clinical trials; cluster analysis; DMXAA; Drug Evaluation, Preclinical; Female; Influenza A Virus, H1N1 Subtype - chemistry; Influenza A Virus, H1N1 Subtype - immunology; influenza vaccines; Influenza Vaccines - chemistry; Influenza Vaccines - immunology; Influenza Vaccines - pharmacology; intranasal administration; lungs; Mice; Mice, Inbred BALB C; NanoSiO2; Pam3CSK4; phenotype; Preclinical study; QuantiGene plex; screening; T-lymphocytes; toxicity; vaccine adjuvants; Vaccine safety; QuantiGene plex; Preclinical study; Vaccine safety; Nlrp3; DMXAA; SA; IFN; RE; WBCs; Biomarkers; Pam3CSK4; HA; STING; Adjuvant; QGP; TLR; Alum; HAv; WPv; NanoSiO2; PamCSK; NanoSiO