Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis
The objective of this study is to investigate the serum beta-2-microglobulin (B2MG) and advanced oxidation protein products (AOPP) as middle molecule uremic toxins and protein carbonyl (PCO) as oxidative stress marker in uremic patients undergoing high-flux versus low-flux hemodialysis (HD) and to c...
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Published in | Saudi journal of kidney diseases and transplantation Vol. 24; no. 5; pp. 930 - 937 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Riyadh, Saudi Arabia
Saudi Center for Organ Transplantation
01.09.2013
Medknow Publications and Media Pvt. Ltd Wolters Kluwer Medknow Publications |
Subjects | |
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Abstract | The objective of this study is to investigate the serum beta-2-microglobulin
(B2MG) and advanced oxidation protein products (AOPP) as middle molecule uremic toxins and
protein carbonyl (PCO) as oxidative stress marker in uremic patients undergoing high-flux versus
low-flux hemodialysis (HD) and to correlate their levels to the erythropoietin requirements for
those patients. Twenty patients on chronic low-flux HD were recruited in the study. At the start of
the study, all patients underwent high-flux HD for eight weeks, followed by low-flux HD for two
weeks as a washout period. The patients were then subjected to another eight weeks of low-flux
HD. Blood samples were obtained at the beginning and at the end of the high-flux period and the
low-flux period. The mean erythropoietin dose for patients using high-flux HD was significantly
lower than that for low-flux HD (P = 0.0062). Post-high flux, the B2MG and PCO levels were
significantly lower than the pre-high-flux levels (P = 0.026 and 0.0005, respectively), but no
significant change was observed in AOPP (P = 0.68). Post-low flux, the B2MG, AOPP and PCO
were significantly higher than the pre-low-flux levels (P = 0.0002, 0.021 and <0.0001, respectively).
Post-low flux, the B2MG and PCO were significantly higher than the post-high-flux
levels (P <0.0001), but no significant difference was observed in AOPP (P = 0.11). High-flux HD
results in reduction of some of the middle molecule toxins and PCO levels better than low-flux
HD, and is associated with a better response to erythropoietin. |
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AbstractList | The objective of this study is to investigate the serum beta-2-microglobulin (B2MG) and advanced oxidation protein products (AOPP) as middle molecule uremic toxins and protein carbonyl (PCO) as oxidative stress marker in uremic patients undergoing high-flux versus low-flux hemodialysis (HD) and to correlate their levels to the erythropoietin requirements for those patients. Twenty patients on chronic low-flux HD were recruited in the study. At the start of the study, all patients underwent high-flux HD for eight weeks, followed by low-flux HD for two weeks as a washout period. The patients were then subjected to another eight weeks of low-flux HD. Blood samples were obtained at the beginning and at the end of the high-flux period and the low-flux period. The mean erythropoietin dose for patients using high-flux HD was significantly lower than that for low-flux HD (P = 0.0062). Post-high flux, the B2MG and PCO levels were significantly lower than the pre-high-flux levels (P = 0.026 and 0.0005, respectively), but no significant change was observed in AOPP (P = 0.68). Post-low flux, the B2MG, AOPP and PCO were significantly higher than the pre-low-flux levels (P = 0.0002, 0.021 and <0.0001, respectively). Post-low flux, the B2MG and PCO were significantly higher than the post-high-flux levels (P <0.0001), but no significant difference was observed in AOPP (P = 0.11). High-flux HD results in reduction of some of the middle molecule toxins and PCO levels better than low-flux HD, and is associated with a better response to erythropoietin. The objective of this study is to investigate the serum beta-2-microglobulin (B2MG) and advanced oxidation protein products (AOPP) as middle molecule uremic toxins and protein carbonyl (PCO) as oxidative stress marker in uremic patients undergoing high-flux versus low-flux hemodialysis (HD) and to correlate their levels to the erythropoietin requirements for those patients. Twenty patients on chronic low-flux HD were recruited in the study. At the start of the study, all patients underwent high-flux HD for eight weeks, followed by low-flux HD for two weeks as a washout period. The patients were then subjected to another eight weeks of low-flux HD. Blood samples were obtained at the beginning and at the end of the high-flux period and the low-flux period. The mean erythropoietin dose for patients using high-flux HD was significantly lower than that for low-flux HD (P = 0.0062). Post-high flux, the B2MG and PCO levels were significantly lower than the pre-high-flux levels (P = 0.026 and 0.0005, respectively), but no significant change was observed in AOPP (P = 0.68). Post-low flux, the B2MG, AOPP and PCO were significantly higher than the pre-low-flux levels (P = 0.0002, 0.021 and <0.0001, respectively). Post-low flux, the B2MG and PCO were significantly higher than the post-high-flux levels (P <0.0001), but no significant difference was observed in AOPP (P = 0.11). High-flux HD results in reduction of some of the middle molecule toxins and PCO levels better than low-flux HD, and is associated with a better response to erythropoietin. |
Audience | Academic |
Author | al-Jawhari, Iman E. al-Wakil, Halah S. Abu al-Suud, Nahlah A. Abu Zayd, Ablah A. |
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(B2MG) and advanced oxidation protein products (AOPP) as middle molecule uremic... The objective of this study is to investigate the serum beta-2-microglobulin (B2MG) and advanced oxidation protein products (AOPP) as middle molecule uremic... |
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SubjectTerms | Advanced Oxidation Protein Products - blood beta 2-Microglobulin - blood Beta lactamases Cross-Over Studies Erythropoietin Erythropoietin - administration & dosage Female Health aspects Hemodialysis Humans Male Membranes, Artificial Oxidation Oxidative Stress Patient outcomes Physiological aspects Protein Carbonylation - physiology Renal Dialysis - methods Toxins, Biological - blood Uremia - blood Uremia - therapy الأكسدة الإجهاد التأكسدي الإريثروبويتين التشخيص الدم المرضى غسيل الكلى |
Title | Relation of middle molecules levels and oxidative stress to erythropoietin requirements in high-flux versus low-flux hemodialysis |
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