Canonical Wnt pathway gene expression and their clinical correlation in oral squamous cell carcinoma

• Published in: Indian journal of dental research Vol. 29; no. 3; pp. 291 - 297
• Main Authors: Marimuthu, Madhulaxmi, Andiappan, Manoharan, Wahab, Abdul, Muthusekhar, M, Balakrishnan, Anandan, Shanmugam, Sambandham
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.05.2018; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Adaptor Proteins, Signal Transducing; c-Myc protein; Cancer genetics; Cancer therapies; Canonical Wnt pathway; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - surgery; Care and treatment; Cell cycle; Cyclin D1; Data processing; Dkk1 protein; DNA-Binding Proteins; Eye Proteins; Female; Frizzled protein; Frizzled-related protein 1; gene analysis; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Genetic research; Humans; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Male; Maxillofacial surgery; Medical research; Membrane Proteins; Metastasis; Middle Aged; Mouth Neoplasms - genetics; Mouth Neoplasms - surgery; Myc protein; Oral cancer; Oral squamous cell carcinoma; Patients; Polymerase chain reaction; Prognosis; Prospective Studies; Proto-Oncogene Mas; Proto-Oncogene Proteins; quantitative reverse transcription-polymerase chain reaction; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Reverse transcription; RNA; Signal transduction; Squamous cell carcinoma; Standard deviation; Statistical analysis; Stem cells; Studies; Surgery; Transcription Factors; Wnt protein; Wnt Signaling Pathway - genetics; β-catenin; United States > US; Germany; oral squamous cell carcinoma; quantitative reverse transcription-polymerase chain reaction; gene analysis; Canonical Wnt pathway

Aim: The aim of this study is to explore the prognostic significance and clinicopathological correlations of the Wnt pathway genes in a cohort of surgically treated patients with oral squamous cell carcinoma (OSCC) patients. Settings and Design: A prospective genetic study on patients with OSCC was...