AMPK in skeletal muscle function and metabolism
Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine‐tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying...
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| Published in | The FASEB journal Vol. 32; no. 4; pp. 1741 - 1777 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Federation of American Societies for Experimental Biology
01.04.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0892-6638 1530-6860 |
| DOI | 10.1096/fj.201700442R |
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| Abstract | Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine‐tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism (e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.— Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.‐N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism. FASEB J. 32, 1741–1777 (2018). www.fasebj.org |
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| AbstractList | Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism ( e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.-Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.-N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism. Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine‐tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism (e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.— Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.‐N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism. FASEB J. 32, 1741–1777 (2018). www.fasebj.org |
| Author | Wojtaszewski, Jørgen F. P. Pehmøller, Christian Viollet, Benoit Treebak, Jonas T. Shum, Michael Fentz, Joachim Mounier, Remi Lantier, Louise Sanz, Maria‐Nieves Hingst, Janne R. Foretz, Marc Kjøbsted, Rasmus Marette, André |
| Author_xml | – sequence: 1 givenname: Rasmus surname: Kjøbsted fullname: Kjøbsted, Rasmus email: rasmus.kjobsted@nexs.ku.dk organization: University of Copenhagen – sequence: 2 givenname: Janne R. surname: Hingst fullname: Hingst, Janne R. organization: University of Copenhagen – sequence: 3 givenname: Joachim surname: Fentz fullname: Fentz, Joachim organization: University of Copenhagen – sequence: 4 givenname: Marc surname: Foretz fullname: Foretz, Marc organization: Université Paris Descartes, Sorbonne Paris Cité – sequence: 5 givenname: Maria‐Nieves surname: Sanz fullname: Sanz, Maria‐Nieves organization: University of Bern – sequence: 6 givenname: Christian surname: Pehmøller fullname: Pehmøller, Christian organization: Internal Medicine Research Unit, Pfizer Global Research and Development – sequence: 7 givenname: Michael surname: Shum fullname: Shum, Michael organization: Laval University – sequence: 8 givenname: André surname: Marette fullname: Marette, André organization: Laval University – sequence: 9 givenname: Remi surname: Mounier fullname: Mounier, Remi organization: Université Claude Bernard Lyon 1, INSERM Unite 1217, CNRS UMR – sequence: 10 givenname: Jonas T. surname: Treebak fullname: Treebak, Jonas T. organization: University of Copenhagen – sequence: 11 givenname: Jørgen F. P. surname: Wojtaszewski fullname: Wojtaszewski, Jørgen F. P. organization: University of Copenhagen – sequence: 12 givenname: Benoit surname: Viollet fullname: Viollet, Benoit organization: Université Paris Descartes, Sorbonne Paris Cité – sequence: 13 givenname: Louise surname: Lantier fullname: Lantier, Louise email: louise.lantier@vanderbilt.edu organization: Vanderbilt University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29242278$$D View this record in MEDLINE/PubMed |
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| Keywords | exercise plasticity glucose uptake diabetes mitochondria |
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| SubjectTerms | Adaptation, Physiological Animals diabetes Energy Metabolism Exercise glucose uptake Humans mitochondria Muscle, Skeletal - metabolism Muscle, Skeletal - physiology plasticity Protein Kinases - chemistry Protein Kinases - genetics Protein Kinases - metabolism |
| Title | AMPK in skeletal muscle function and metabolism |
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