Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2- and 3-dimensional environments

• Published in: The FASEB journal Vol. 31; no. 4; p. 1461
• Main Authors: Kim, Hye-Jin, Kwon, Sojung, Nam, Seo Hee, Jung, Jae Woo, Kang, Minkyung, Ryu, Jihye, Kim, Ji Eon, Cheong, Jin-Gyu, Cho, Chang Yun, Kim, Somi, Song, Dae-Geun, Kim, Yong-Nyun, Kim, Tai Young, Jung, Min-Kyo, Lee, Kyung-Min, Pack, Chan-Gi, Lee, Jung Weon
• Format: Journal Article
• Language: English
• Published: United States 01.04.2017
• Subjects: Cell Line, Tumor; Cell Movement; Cholesterol - metabolism; Glycosylation; HEK293 Cells; Hepatocytes - metabolism; Hepatocytes - physiology; Hepatocytes - ultrastructure; Humans; Integrin alpha5 - metabolism; Lipoylation; Membrane Microdomains - metabolism; Membrane Microdomains - ultrastructure; Membrane Proteins - metabolism; Protein Binding; Protein Processing, Post-Translational; Receptor, Epidermal Growth Factor - metabolism; migration; 3D cell culture; membrane proteins; protein interaction affinity; FCCS

Membrane proteins sense extracellular cues and transduce intracellular signaling to coordinate directionality and speed during cellular migration. They are often localized to specific regions, as with lipid rafts or tetraspanin-enriched microdomains; however, the dynamic interactions of tetraspanins...