Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior

• Published in: Genes, brain and behavior Vol. 15; no. 2; pp. 280 - 290
• Main Authors: He, X., Zhou, S., St. Armour, G. E., Mackay, T. F. C., Anholt, R. R. H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2016; John Wiley & Sons, Inc
• Subjects: Animals; Behavior; Behavior, Animal - physiology; Chemosensation; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila melanogaster - physiology; Drosophila melanogaster Genetic Reference Panel; Epistasis, Genetic - genetics; Gene loci; Genes, Insect - genetics; genetic architecture; Genetic Variation - genetics; Genome-Wide Association Study; Genomes; Genotype; Insects; Mutation - genetics; Olfactory Bulb - physiology; Original; Phenotype; quantitative traits; quantitative traits; genetic architecture; Chemosensation; genome-wide association study; Drosophila melanogaster Genetic Reference Panel

The extent to which epistasis affects the genetic architecture of complex traits is difficult to quantify, and identifying variants in natural populations with epistatic interactions is challenging. Previous studies in Drosophila implicated extensive epistasis between variants in genes that affect n...