Inhibition Peroxiredoxin‐2 by Capsaicin Ameliorates Rheumatoid Arthritis via ROS‐Mediated Apoptosis in Fibroblast‐Like Synoviocytes

ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage. Capsaicin (CAP), from Capsicum annuum L., is known for its burning sensation‐inducing prop...

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Published inMedComm (2020) Vol. 6; no. 6; pp. e70209 - n/a
Main Authors He, Hengkai, Hao, Mingjing, Luo, Piao, Chen, Junhui, An, Yehai, Huang, Jingnan, He, Ruiyi, Du, Qingfeng, Zhang, Qian, Wang, Jigang
Format Journal Article
LanguageEnglish
Published China John Wiley & Sons, Inc 01.06.2025
John Wiley and Sons Inc
Wiley
Subjects
activity‐based protein profiling
antioxidant
capsaicin
Original
peroxiredoxin‐2
rheumatoid arthritis
activity‐based protein profiling
antioxidant
peroxiredoxin‐2
rheumatoid arthritis
capsaicin
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Abstract ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage. Capsaicin (CAP), from Capsicum annuum L., is known for its burning sensation‐inducing property and has shown various pharmacological effects, yet its specific mechanisms and targets in RA treatment remain largely unclear. This study aimed to investigate the role of CAP in RA by synthesizing CAP probes and using activity‐based protein profiling. We found that CAP reduced joint swelling in arthritic mice and exerted anti‐inflammatory and antiproliferative effects on fibroblast‐like synoviocytes. We identified that CAP binds to PRDX2, inhibiting its antioxidant function and inducing oxidative stress and apoptosis, contributing to the antiarthritic effects. These results suggest that PRDX2 is a potential target for CAP in RA treatment, providing new insights into the molecular mechanisms and potential therapeutic strategies for RA. Capsaicin attenuating arthritis by inhibiting AKT phosphorylation and activating the NRF2–HO‐1 axis via targeting PRDX2
AbstractList ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage. Capsaicin (CAP), from Capsicum annuum L., is known for its burning sensation‐inducing property and has shown various pharmacological effects, yet its specific mechanisms and targets in RA treatment remain largely unclear. This study aimed to investigate the role of CAP in RA by synthesizing CAP probes and using activity‐based protein profiling. We found that CAP reduced joint swelling in arthritic mice and exerted anti‐inflammatory and antiproliferative effects on fibroblast‐like synoviocytes. We identified that CAP binds to PRDX2, inhibiting its antioxidant function and inducing oxidative stress and apoptosis, contributing to the antiarthritic effects. These results suggest that PRDX2 is a potential target for CAP in RA treatment, providing new insights into the molecular mechanisms and potential therapeutic strategies for RA.
Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage. Capsaicin (CAP), from Capsicum annuum L., is known for its burning sensation‐inducing property and has shown various pharmacological effects, yet its specific mechanisms and targets in RA treatment remain largely unclear. This study aimed to investigate the role of CAP in RA by synthesizing CAP probes and using activity‐based protein profiling. We found that CAP reduced joint swelling in arthritic mice and exerted anti‐inflammatory and antiproliferative effects on fibroblast‐like synoviocytes. We identified that CAP binds to PRDX2, inhibiting its antioxidant function and inducing oxidative stress and apoptosis, contributing to the antiarthritic effects. These results suggest that PRDX2 is a potential target for CAP in RA treatment, providing new insights into the molecular mechanisms and potential therapeutic strategies for RA.
Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage. Capsaicin (CAP), from Capsicum annuum L., is known for its burning sensation-inducing property and has shown various pharmacological effects, yet its specific mechanisms and targets in RA treatment remain largely unclear. This study aimed to investigate the role of CAP in RA by synthesizing CAP probes and using activity-based protein profiling. We found that CAP reduced joint swelling in arthritic mice and exerted anti-inflammatory and antiproliferative effects on fibroblast-like synoviocytes. We identified that CAP binds to PRDX2, inhibiting its antioxidant function and inducing oxidative stress and apoptosis, contributing to the antiarthritic effects. These results suggest that PRDX2 is a potential target for CAP in RA treatment, providing new insights into the molecular mechanisms and potential therapeutic strategies for RA.Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage. Capsaicin (CAP), from Capsicum annuum L., is known for its burning sensation-inducing property and has shown various pharmacological effects, yet its specific mechanisms and targets in RA treatment remain largely unclear. This study aimed to investigate the role of CAP in RA by synthesizing CAP probes and using activity-based protein profiling. We found that CAP reduced joint swelling in arthritic mice and exerted anti-inflammatory and antiproliferative effects on fibroblast-like synoviocytes. We identified that CAP binds to PRDX2, inhibiting its antioxidant function and inducing oxidative stress and apoptosis, contributing to the antiarthritic effects. These results suggest that PRDX2 is a potential target for CAP in RA treatment, providing new insights into the molecular mechanisms and potential therapeutic strategies for RA.
Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage. Capsaicin (CAP), from Capsicum annuum L ., is known for its burning sensation‐inducing property and has shown various pharmacological effects, yet its specific mechanisms and targets in RA treatment remain largely unclear. This study aimed to investigate the role of CAP in RA by synthesizing CAP probes and using activity‐based protein profiling. We found that CAP reduced joint swelling in arthritic mice and exerted anti‐inflammatory and antiproliferative effects on fibroblast‐like synoviocytes. We identified that CAP binds to PRDX2, inhibiting its antioxidant function and inducing oxidative stress and apoptosis, contributing to the antiarthritic effects. These results suggest that PRDX2 is a potential target for CAP in RA treatment, providing new insights into the molecular mechanisms and potential therapeutic strategies for RA. Capsaicin attenuating arthritis by inhibiting AKT phosphorylation and activating the NRF2–HO‐1 axis via targeting PRDX2
ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage. Capsaicin (CAP), from Capsicum annuum L., is known for its burning sensation‐inducing property and has shown various pharmacological effects, yet its specific mechanisms and targets in RA treatment remain largely unclear. This study aimed to investigate the role of CAP in RA by synthesizing CAP probes and using activity‐based protein profiling. We found that CAP reduced joint swelling in arthritic mice and exerted anti‐inflammatory and antiproliferative effects on fibroblast‐like synoviocytes. We identified that CAP binds to PRDX2, inhibiting its antioxidant function and inducing oxidative stress and apoptosis, contributing to the antiarthritic effects. These results suggest that PRDX2 is a potential target for CAP in RA treatment, providing new insights into the molecular mechanisms and potential therapeutic strategies for RA. Capsaicin attenuating arthritis by inhibiting AKT phosphorylation and activating the NRF2–HO‐1 axis via targeting PRDX2
Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage. Capsaicin (CAP), from ., is known for its burning sensation-inducing property and has shown various pharmacological effects, yet its specific mechanisms and targets in RA treatment remain largely unclear. This study aimed to investigate the role of CAP in RA by synthesizing CAP probes and using activity-based protein profiling. We found that CAP reduced joint swelling in arthritic mice and exerted anti-inflammatory and antiproliferative effects on fibroblast-like synoviocytes. We identified that CAP binds to PRDX2, inhibiting its antioxidant function and inducing oxidative stress and apoptosis, contributing to the antiarthritic effects. These results suggest that PRDX2 is a potential target for CAP in RA treatment, providing new insights into the molecular mechanisms and potential therapeutic strategies for RA.
Author He, Hengkai
Chen, Junhui
Huang, Jingnan
An, Yehai
He, Ruiyi
Zhang, Qian
Hao, Mingjing
Luo, Piao
Du, Qingfeng
Wang, Jigang
AuthorAffiliation 5 State Key Laboratory for Quality Ensurance and Sustainable Use of Dao‐di Herbs Artemisinin Research Center and Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China
4 Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases Guangzhou China
3 Department of Pulmonary and Critical Care Medicine Shenzhen Institute of Respiratory Diseases and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medical College of Jinan University Shenzhen Guangdong China
1 Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics School of Traditional Chinese Medicine and School of pharmaceutical Sciences Southern Medical University Guangzhou China
2 State Key Laboratory of Southwestern Chinese Medicine Resource School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu Ch
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Issue 6
Keywords activity‐based protein profiling
antioxidant
peroxiredoxin‐2
rheumatoid arthritis
capsaicin
Language English
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Notes Funding
Hengkai He, Mingjing Hao, and Piao Luo contributed equally to this work.
This work was supported by the National Science and Technology Major Project of China (2024ZD0523402), National Key Research and Development Program of China (2020YFA0908000), Science and Technology Project of Guangzhou City (2024A04J4155), and Project of Administration of Traditional Chinese Medicine of Guangdong Province of China (20241205).
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Funding: This work was supported by the National Science and Technology Major Project of China (2024ZD0523402), National Key Research and Development Program of China (2020YFA0908000), Science and Technology Project of Guangzhou City (2024A04J4155), and Project of Administration of Traditional Chinese Medicine of Guangdong Province of China (20241205).
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Snippet ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own...
Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues,...
ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own...
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SubjectTerms activity‐based protein profiling
antioxidant
capsaicin
Original
peroxiredoxin‐2
rheumatoid arthritis
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Title Inhibition Peroxiredoxin‐2 by Capsaicin Ameliorates Rheumatoid Arthritis via ROS‐Mediated Apoptosis in Fibroblast‐Like Synoviocytes
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Volume 6
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