Iron-catalyzed cross-coupling of heteroaromatic tosylates with alkyl and aryl Grignard reagents

• Published in: Applied organometallic chemistry Vol. 29; no. 5; pp. 296 - 300
• Main Authors: Chen, Xu, Quan, Zheng-Jun, Wang, Xi-Cun
• Format: Journal Article
• Language: English
• Published: Blackwell Publishing Ltd 01.05.2015
• Subjects: Aromatic compounds; cross-coupling; Derivatives; Grignard reagents; heteroaromatic sulfonates; Ligands; Metalorganic compounds; Pyridines; pyrimidine derivatives; Pyrimidines; Reaction time

An Fe(III)‐catalyzed cross‐coupling of N‐heteroaromatic tosylates with aryl and alkyl Grignard reagents is presented. The reaction proceeds at −20°C to room temperature with short reaction time (15–30 min.), and the corresponding products are obtained with moderate to high yields. In particular, low...