The role of SARS‐CoV‐2 target ACE2 in cardiovascular diseases

SARS‐CoV‐2, the virus responsible for the global coronavirus disease (COVID‐19) pandemic, attacks multiple organs of the human body by binding to angiotensin‐converting enzyme 2 (ACE2) to enter cells. More than 20 million people have already been infected by the virus. ACE2 is not only a functional...

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Published inJournal of Cellular and Molecular Medicine Vol. 25; no. 3; pp. 1342 - 1349
Main Authors Zhu, Hanzhao, Zhang, Liyun, Ma, Yubo, Zhai, Mengen, Xia, Lin, Liu, Jincheng, Yu, Shiqiang, Duan, Weixun
Format Journal Article Web Resource
LanguageEnglish
Published England John Wiley & Sons, Inc 01.02.2021
John Wiley and Sons Inc
Subjects
ACE2
Angiotensin
Angiotensin II
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - metabolism
Angiotensin-Converting Enzyme 2 - pharmacology
Animals
Antioxidants
Apoptosis
Arrhythmias, Cardiac - metabolism
Arrhythmias, Cardiac - physiopathology
Blood pressure
Calcium
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - complications
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Cardiovascular system
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - metabolism
COVID-19 Drug Treatment
Diminazene - pharmacology
Drugs
Enzymes
Fibrosis
Heart
Heart Failure - etiology
Humans
Hypertension
Hypertension - metabolism
Hypertension - physiopathology
Inflammation
Kinases
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Pandemics
Peptides
Proteins
RAS
Recombinant Proteins - pharmacology
Renin
Review
Reviews
SARS‐CoV‐2
Severe acute respiratory syndrome coronavirus 2
Transforming growth factor-b
ACE2
SARS-CoV-2
cardiovascular diseases
RAS
Online AccessGet full text

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Abstract SARS‐CoV‐2, the virus responsible for the global coronavirus disease (COVID‐19) pandemic, attacks multiple organs of the human body by binding to angiotensin‐converting enzyme 2 (ACE2) to enter cells. More than 20 million people have already been infected by the virus. ACE2 is not only a functional receptor of COVID‐19 but also an important endogenous antagonist of the renin‐angiotensin system (RAS). A large number of studies have shown that ACE2 can reverse myocardial injury in various cardiovascular diseases (CVDs) as well as is exert anti‐inflammatory, antioxidant, anti‐apoptotic and anticardiomyocyte fibrosis effects by regulating transforming growth factor beta, mitogen‐activated protein kinases, calcium ions in cells and other major pathways. The ACE2/angiotensin‐(1‐7)/Mas receptor axis plays a decisive role in the cardiovascular system to combat the negative effects of the ACE/angiotensin II/angiotensin II type 1 receptor axis. However, the underlying mechanism of ACE2 in cardiac protection remains unclear. Some approaches for enhancing ACE2 expression in CVDs have been suggested, which may provide targets for the development of novel clinical therapies. In this review, we aimed to identify and summarize the role of ACE2 in CVDs.
AbstractList SARS‐CoV‐2, the virus responsible for the global coronavirus disease (COVID‐19) pandemic, attacks multiple organs of the human body by binding to angiotensin‐converting enzyme 2 (ACE2) to enter cells. More than 20 million people have already been infected by the virus. ACE2 is not only a functional receptor of COVID‐19 but also an important endogenous antagonist of the renin‐angiotensin system (RAS). A large number of studies have shown that ACE2 can reverse myocardial injury in various cardiovascular diseases (CVDs) as well as is exert anti‐inflammatory, antioxidant, anti‐apoptotic and anticardiomyocyte fibrosis effects by regulating transforming growth factor beta, mitogen‐activated protein kinases, calcium ions in cells and other major pathways. The ACE2/angiotensin‐(1‐7)/Mas receptor axis plays a decisive role in the cardiovascular system to combat the negative effects of the ACE/angiotensin II/angiotensin II type 1 receptor axis. However, the underlying mechanism of ACE2 in cardiac protection remains unclear. Some approaches for enhancing ACE2 expression in CVDs have been suggested, which may provide targets for the development of novel clinical therapies. In this review, we aimed to identify and summarize the role of ACE2 in CVDs.
Abstract SARS‐CoV‐2, the virus responsible for the global coronavirus disease (COVID‐19) pandemic, attacks multiple organs of the human body by binding to angiotensin‐converting enzyme 2 (ACE2) to enter cells. More than 20 million people have already been infected by the virus. ACE2 is not only a functional receptor of COVID‐19 but also an important endogenous antagonist of the renin‐angiotensin system (RAS). A large number of studies have shown that ACE2 can reverse myocardial injury in various cardiovascular diseases (CVDs) as well as is exert anti‐inflammatory, antioxidant, anti‐apoptotic and anticardiomyocyte fibrosis effects by regulating transforming growth factor beta, mitogen‐activated protein kinases, calcium ions in cells and other major pathways. The ACE2/angiotensin‐(1‐7)/Mas receptor axis plays a decisive role in the cardiovascular system to combat the negative effects of the ACE/angiotensin II/angiotensin II type 1 receptor axis. However, the underlying mechanism of ACE2 in cardiac protection remains unclear. Some approaches for enhancing ACE2 expression in CVDs have been suggested, which may provide targets for the development of novel clinical therapies. In this review, we aimed to identify and summarize the role of ACE2 in CVDs.
Author Zhai, Mengen
Zhu, Hanzhao
Liu, Jincheng
Ma, Yubo
Zhang, Liyun
Xia, Lin
Duan, Weixun
Yu, Shiqiang
AuthorAffiliation 2 Department of Dermatology and Venereology Peking University First Hospita Beijing China
1 Department of Cardiovascular Surgery The First Affiliated Hospital The Air Force Medical University Xi’an China
AuthorAffiliation_xml – name: 1 Department of Cardiovascular Surgery The First Affiliated Hospital The Air Force Medical University Xi’an China
– name: 2 Department of Dermatology and Venereology Peking University First Hospita Beijing China
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  surname: Zhai
  fullname: Zhai, Mengen
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  givenname: Weixun
  surname: Duan
  fullname: Duan, Weixun
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  organization: The Air Force Medical University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33443816$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1161/CIR.0000000000000659
10.1016/S0140-6736(20)30251-8
10.1113/EP085884
10.1056/NEJMoa2007621
10.1016/j.cardiores.2007.04.007
10.1161/CIRCRESAHA.109.208645
10.1038/srep08794
10.1038/s41422-020-0282-0
10.1093/europace/euu070
10.1164/rccm.201712-2570OC
10.1089/hum.2009.160
10.1016/S0140-6736(20)30566-3
10.1148/radiol.2020200370
10.1164/rccm.201205-0880OC
10.1113/expphysiol.2009.047407
10.1001/jama.2020.1585
10.1042/CS20070160
10.1161/01.RES.87.5.e1
10.1161/01.RES.0000187500.24964.7A
10.1038/s41586-020-2012-7
10.3390/ijms21124200
10.1161/CIRCHEARTFAILURE.113.000672
10.1038/s41467-020-14867-z
10.1016/j.jacc.2008.02.088
10.1161/HYPERTENSIONAHA.107.100693
10.1016/S0022-2828(03)00177-9
10.1093/eurheartj/ehy339
10.1002/path.1570
10.1093/eurheartj/ehaa388
10.1016/S0140-6736(20)30183-5
10.1016/j.bcp.2015.03.009
10.1002/ejp.512
10.1016/j.yjmcc.2020.05.007
10.1016/j.cardfail.2009.09.005
10.1152/ajpregu.00292.2006
10.3892/etm.2014.1640
10.1093/cvr/cvr036
10.1590/S1726-46342011000200013
10.1164/rccm.200811-1678OC
10.1001/jamacardio.2020.1096
10.1161/HYPERTENSIONAHA.120.15082
10.1161/CIRCHEARTFAILURE.108.840124
10.1007/s10741-011-9259-x
10.3892/mmr.2017.6848
10.1002/ejhf.1871
10.1038/nature00786
10.1111/eci.12854
10.1016/j.cjca.2016.12.012
10.1161/HYPERTENSIONAHA.112.191650
10.1074/jbc.M002615200
10.1016/j.jacc.2016.11.064
10.1172/JCI16980
10.1161/HYPERTENSIONAHA.108.114322
10.1016/j.bcp.2017.07.022
10.1152/ajprenal.00139.2006
10.1093/eurheartj/ehi114
10.1152/ajpheart.00563.2014
10.1093/eurheartj/ehaa084
10.1074/jbc.M200581200
10.1097/FJC.0000000000000374
10.1038/s41586-020-2423-5
10.1093/eurheartj/ehaa373
10.1371/journal.pone.0061695
10.1016/j.pcad.2020.03.001
10.1007/s00380-016-0936-5
10.1016/j.pharep.2019.05.008
10.1007/s00395-015-0499-0
10.1161/CIRCRESAHA.113.301811
10.1007/s00395-015-0477-6
10.1073/pnas.1432869100
10.1016/j.lfs.2016.09.006
10.1093/eurheartj/ehaa414
10.1016/j.cmet.2018.04.002
10.1136/bmj.m1091
10.1016/j.bcp.2018.01.047
10.1177/1753944711409281
10.1161/01.HYP.0000237862.94083.45
10.1161/CIRCRESAHA.116.310509
10.1161/CIRCRESAHA.115.304110
10.1161/CIRCRESAHA.110.227371
10.1016/S0014-5793(02)03640-2
10.3892/mmr.2017.7152
10.3390/ijms20112833
10.1016/j.yjmcc.2016.05.012
10.1016/j.jacc.2011.09.071
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Issue 3
Keywords ACE2
SARS-CoV-2
cardiovascular diseases
RAS
Language English
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Hanzhao Zhu, Liyun Zhang and Yubo Ma contributed equally to this study
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References 2010; 16
2004; 203
2010; 107
2020; 63
2010; 106
2000; 87
2002; 277
2020; 368
2016; 101
2015; 308
2012; 17
2020; 323
2020; 11
2012; 59
2005; 26
2007; 75
2013; 8
2018; 48
2010; 23
2010; 21
2018; 39
2020; S0168–8278
2020; 295
2019; 20
2007; 292
2017; 33
2017; 32
2014; 16
2020; 579
2013; 113
2019; 2020
2014; 18
2017; 121
2011; 28
2014; 7
2017; 169
2019; 71
2015; 5
2020; 41
2020; 382
2017; 69
2015; 95
2002; 532
2003; 35
2016; 97
2009; 179
2020; 144
2020; 585
2000; 275
2008; 52
2013; 187
2002; 417
2006; 116
2008; 51
2020; S0033–0620
2011; 5
2018; 27
2014; 115
2007; 113
2018; 198
2018; 151
2020; 75
2020; 30
2011; 91
2020
2020; 395
2017; 16
2015; 110
2006; 48
2020; 28
2005; 97
2017; 19
2020; 22
2019; 139
2020; 21
2017; 144
2009; 2
2003; 100
2010; 95
2016; 67
e_1_2_11_70_1
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e_1_2_11_30_1
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e_1_2_11_51_1
e_1_2_11_74_1
e_1_2_11_13_1
e_1_2_11_34_1
e_1_2_11_53_1
e_1_2_11_76_1
e_1_2_11_11_1
e_1_2_11_29_1
e_1_2_11_6_1
e_1_2_11_27_1
e_1_2_11_4_1
e_1_2_11_48_1
e_1_2_11_2_1
Li JW (e_1_2_11_28_1) 2020; 0033
e_1_2_11_83_1
e_1_2_11_60_1
e_1_2_11_81_1
e_1_2_11_20_1
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e_1_2_11_89_1
e_1_2_11_41_1
e_1_2_11_62_1
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e_1_2_11_50_1
e_1_2_11_71_1
e_1_2_11_92_1
e_1_2_11_90_1
Liu C (e_1_2_11_5_1) 2020; 28
e_1_2_11_10_1
e_1_2_11_31_1
e_1_2_11_56_1
e_1_2_11_77_1
e_1_2_11_58_1
e_1_2_11_79_1
e_1_2_11_14_1
Walters TE (e_1_2_11_67_1) 2017; 19
e_1_2_11_35_1
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e_1_2_11_82_1
e_1_2_11_61_1
e_1_2_11_80_1
Guo T (e_1_2_11_24_1) 2019; 2020
Asselah T (e_1_2_11_36_1) 2020; 0168
e_1_2_11_21_1
e_1_2_11_44_1
e_1_2_11_46_1
e_1_2_11_69_1
e_1_2_11_88_1
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e_1_2_11_40_1
e_1_2_11_63_1
e_1_2_11_86_1
e_1_2_11_9_1
e_1_2_11_23_1
e_1_2_11_42_1
e_1_2_11_65_1
e_1_2_11_84_1
Calò LA (e_1_2_11_64_1) 2010; 23
e_1_2_11_18_1
e_1_2_11_16_1
e_1_2_11_37_1
e_1_2_11_39_1
References_xml – volume: 16
  start-page: 4791
  issue: 4
  year: 2017
  end-page: 4796
  article-title: Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity
  publication-title: Mol Med Rep
– volume: 63
  start-page: 390
  issue: 3
  year: 2020
  end-page: 391
  article-title: Cardiac troponin I in patients with coronavirus disease 2019 (COVID‐19): Evidence from a meta‐analysis
  publication-title: Prog Cardiovasc Dis
– volume: 116
  start-page: 2218
  issue: 8
  year: 2006
  end-page: 2225
  article-title: Altered blood pressure responses and normal cardiac phenotype in ACE2‐null mice
  publication-title: J Clin Invest
– volume: 52
  start-page: 967
  issue: 5
  year: 2008
  end-page: 973
  article-title: Transgenic angiotensin‐converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function
  publication-title: Hypertension
– volume: 41
  start-page: 1810
  issue: 19
  year: 2020
  end-page: 1817
  article-title: Circulating plasma concentrations of angiotensin‐converting enzyme 2 in men and women with heart failure and effects of renin‐angiotensin‐aldosterone inhibitors
  publication-title: Eur Heart J
– volume: S0168–8278
  start-page: 33675
  issue: 20
  year: 2020
  end-page: 33678
  article-title: COVID‐19: Discovery, diagnostics and drug development
  publication-title: J Hepatol
– volume: 32
  start-page: 618
  issue: 5
  year: 2017
  end-page: 627
  article-title: The effect of fluvastatin on cardiac fibrosis and angiotensin‐converting enzyme‐2 expression in glucose‐controlled diabetic rat hearts
  publication-title: Heart Vessels
– volume: 151
  start-page: 126
  year: 2018
  end-page: 134
  article-title: Angiotensin 1–7 ameliorates 6‐hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor/PI3K/Akt/BDNF pathway and inhibition of angiotensin II type‐1 receptor/NF‐κB axis
  publication-title: Biochem Pharmacol
– volume: 41
  start-page: 1821
  issue: 19
  year: 2020
  end-page: 1829
  article-title: Characteristics and outcomes of patients hospitalized for COVID‐19 and cardiac disease in Northern Italy
  publication-title: Eur Heart J
– volume: 21
  start-page: E4200
  issue: 12
  year: 2020
  article-title: Role of oxidative stress in the genesis of ventricular arrhythmias
  publication-title: Int J Mol Sci
– volume: 21
  start-page: 1545
  issue: 11
  year: 2010
  end-page: 1554
  article-title: ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction
  publication-title: Hum Gene Ther
– volume: 52
  start-page: 750
  issue: 9
  year: 2008
  end-page: 754
  article-title: Detection of soluble angiotensin‐converting enzyme 2 in heart failure: insights into the endogenous counter‐regulatory pathway of the renin‐angiotensin‐aldosterone system
  publication-title: J Am Coll Cardiol
– volume: 51
  start-page: 712
  issue: 3
  year: 2008
  end-page: 718
  article-title: Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia‐induced pathophysiology
  publication-title: Hypertension
– volume: 292
  start-page: R373
  year: 2007
  end-page: R381
  article-title: Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin–angiotensin system
  publication-title: Am J Physiol Regul Integr Comp Physiol
– volume: 8
  issue: 4
  year: 2013
  article-title: Role of circulating angiotensin converting enzyme 2 in left ventricular remodeling following myocardial infarction: A prospective controlled study
  publication-title: PLoS One
– volume: 18
  start-page: 1471
  issue: 10
  year: 2014
  end-page: 1479
  article-title: Angiotensin (1–7) prevents angiotensin II‐induced nociceptive behaviour via inhibition of p38 MAPK phosphorylation mediated through spinal Mas receptors in mice
  publication-title: Eur J Pain
– volume: 101
  start-page: 1506
  issue: 12
  year: 2016
  end-page: 1516
  article-title: New insights into the elucidation of angiotensin‐(1–7) in vivo antiarrhythmic effects and its related cellular mechanisms
  publication-title: Exp Physiol
– volume: 5
  year: 2015
  article-title: Combination of angiotensin‐(1–7) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy
  publication-title: Sci Rep
– volume: 368
  year: 2020
  article-title: Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study
  publication-title: BMJ
– volume: 22
  start-page: 957
  issue: 6
  year: 2020
  end-page: 966
  article-title: COVID‐19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease
  publication-title: Eur J Heart Fail
– volume: 48
  start-page: 572
  issue: 4
  year: 2006
  end-page: 578
  article-title: Enalapril attenuates downregulation of Angiotensin‐converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
  publication-title: Hypertension
– volume: 198
  start-page: 509
  issue: 4
  year: 2018
  end-page: 520
  article-title: AMP‐activated protein kinase phosphorylation of angiotensin‐converting enzyme 2 in endothelium mitigates pulmonary hypertension
  publication-title: Am J Respir Crit Care Med
– volume: 71
  start-page: 958
  issue: 5
  year: 2019
  end-page: 967
  article-title: Simultaneous inhibition of neprilysin and activation of ACE2 prevented diabetic cardiomyopathy
  publication-title: Pharmacol Rep
– volume: 26
  start-page: 369
  issue: 4
  year: 2005
  end-page: 375
  article-title: Myocardial infarction increases ACE2 expression in rat and humans
  publication-title: Eur Heart J
– volume: 7
  start-page: 1721
  issue: 6
  year: 2014
  end-page: 1727
  article-title: Association between serum angiotensin‐converting enzyme 2 levels and postoperative myocardial infarction following coronary artery bypass grafting
  publication-title: Exp Ther Med
– volume: 91
  start-page: 151
  issue: 1
  year: 2011
  end-page: 161
  article-title: Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit
  publication-title: Cardiovasc Res
– volume: 28
  start-page: 148
  issue: 2
  year: 2020
  end-page: 152
  article-title: Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study
  publication-title: Zhonghua Gan Zang Bing Za Zhi
– volume: 19
  start-page: 1280
  issue: 8
  year: 2017
  end-page: 1287
  article-title: Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling
  publication-title: Europace
– volume: 20
  issue: 11
  year: 2019
  article-title: Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy
  publication-title: Int J Mol Sci
– volume: 69
  start-page: 805
  issue: 7
  year: 2017
  end-page: 819
  article-title: Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure
  publication-title: J Am Coll Cardiol
– volume: 33
  start-page: 943
  issue: 7
  year: 2017
  end-page: 946
  article-title: Recombinant Human ACE2 and the Angiotensin 1–7 Axis as Potential New Therapies for Heart Failure
  publication-title: Can J Cardiol
– volume: 169
  start-page: 69
  year: 2017
  end-page: 75
  article-title: MiRNA‐30e mediated cardioprotection of ACE2 in rats with Doxorubicin‐induced heart failure through inhibiting cardiomyocytes autophagy
  publication-title: Life Sci
– volume: 579
  start-page: 270
  issue: 7798
  year: 2020
  end-page: 273
  article-title: A pneumonia outbreak associated with a new coronavirus of probable bat origin
  publication-title: Nature
– volume: 417
  start-page: 822
  issue: 6891
  year: 2002
  end-page: 828
  article-title: Angiotensin‐converting enzyme 2 is an essential regulator of heart function
  publication-title: Nature
– volume: 395
  start-page: 565
  issue: 10224
  year: 2020
  end-page: 574
  article-title: Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
  publication-title: Lancet
– volume: 115
  start-page: 388
  issue: 3
  year: 2014
  end-page: 399
  article-title: AT₂ receptor activation induces natriuresis and lowers blood pressure
  publication-title: Circ Res
– volume: 97
  start-page: 946
  issue: 9
  year: 2005
  end-page: 953
  article-title: Mineralocorticoid receptor blocker increases angiotensin‐converting enzyme 2 activity in congestive heart failure patients
  publication-title: Circ Res
– year: 2020
  article-title: Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID‐19)
  publication-title: JAMA Cardiol
– volume: 113
  start-page: 357
  issue: 8
  year: 2007
  end-page: 364
  article-title: ACE2 overexpression inhibits hypoxia‐induced collagen production by cardiac fibroblasts
  publication-title: Clin Sci (Lond)
– volume: 121
  start-page: 43
  issue: 1
  year: 2017
  end-page: 55
  article-title: Clinical relevance and role of neuronal AT receptors in ADAM17‐mediated ACE2 shedding in neurogenic hypertension
  publication-title: Circ Res
– volume: 5
  start-page: 159
  issue: 3
  year: 2011
  end-page: 167
  article-title: Beneficial effects of angiotensin (1–7) in diabetic rats with cardiomyopathy
  publication-title: Ther Adv Cardiovasc Dis
– volume: 41
  start-page: 1298
  issue: 12
  year: 2020
  end-page: 1306
  article-title: Heart failure can affect everyone: the ESC Geoffrey Rose lecture
  publication-title: Eur Heart J
– volume: 292
  start-page: F82
  issue: 1
  year: 2007
  end-page: F91
  article-title: Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2‐dependent processing of angiotensin II
  publication-title: Am J Physiol Renal Physiol
– volume: 16
  start-page: 1973
  issue: 2
  year: 2017
  end-page: 1981
  article-title: The ACE2‐Ang (1–7)‐Mas receptor axis attenuates cardiac remodeling and fibrosis in post‐myocardial infarction
  publication-title: Mol Med Rep
– volume: 75
  start-page: 29
  issue: 1
  year: 2007
  end-page: 39
  article-title: Angiotensin II‐mediated oxidative stress and inflammation mediate the age‐dependent cardiomyopathy in ACE2 null mice
  publication-title: Cardiovasc Res
– volume: 35
  start-page: 1043
  issue: 9
  year: 2003
  end-page: 1053
  article-title: Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins
  publication-title: J Mol Cell Cardiol
– volume: S0033–0620
  start-page: 30080
  issue: 20
  year: 2020
  end-page: 30083
  article-title: The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta‐analysis
  publication-title: Prog Cardiovasc Dis
– volume: 67
  start-page: 503
  issue: 6
  year: 2016
  end-page: 509
  article-title: Olmesartan inhibits cardiac hypertrophy in mice overexpressing renin independently of blood pressure: Its beneficial effects on ACE2/Ang(1–7)/Mas axis and NADPH oxidase expression
  publication-title: J Cardiovasc Pharmacol
– volume: 75
  start-page: 1382
  issue: 6
  year: 2020
  end-page: 1385
  article-title: Renin‐angiotensin system blockers and the COVID‐19 pandemic: At present there is no evidence to abandon renin‐angiotensin system blockers
  publication-title: Hypertension
– volume: 179
  start-page: 1048
  issue: 11
  year: 2009
  end-page: 1054
  article-title: Evidence for angiotensin‐converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension
  publication-title: Am J Respir Crit Care Med
– volume: 107
  start-page: 1470
  issue: 12
  year: 2010
  end-page: 1482
  article-title: Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation‐Induced Autophagy in Cardiac Myocytes
  publication-title: Circ Res
– volume: 100
  start-page: 8258
  issue: 14
  year: 2003
  end-page: 8263
  article-title: Angiotensin‐(1–7) is an endogenous ligand for the G protein‐coupled receptor Mas
  publication-title: Proc Natl Acad Sci U S A
– volume: 30
  start-page: 269
  year: 2020
  end-page: 271
  article-title: Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019‐nCoV) in vitro
  publication-title: Cell Res
– volume: 295
  start-page: 715
  issue: 3
  year: 2020
  end-page: 721
  article-title: Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID‐19) pneumonia
  publication-title: Radiology
– volume: 532
  start-page: 107
  issue: 1–2
  year: 2002
  end-page: 110
  article-title: Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme
  publication-title: FEBS Lett
– volume: 275
  start-page: 33238
  year: 2000
  end-page: 33243
  article-title: A human homolog of angiotensin‐converting enzyme. Cloning and functional expression as a captopril‐insensitive carboxypeptidase
  publication-title: J Biol Chem
– volume: 139
  start-page: e56
  issue: 10
  year: 2019
  end-page: e528
  article-title: Heart disease and stroke statistics‐2019 update: A report from the American heart association
  publication-title: Circulation
– volume: 113
  start-page: 1087
  issue: 9
  year: 2013
  end-page: 1096
  article-title: Brain angiotensin‐converting enzyme type 2 shedding contributes to the development of neurogenic hypertension
  publication-title: Circ Res
– volume: 27
  start-page: 1323
  issue: 6
  year: 2018
  end-page: 1337.e5
  article-title: FGF21 prevents angiotensin II‐induced hypertension and vascular dysfunction by activation of ACE2/Angiotensin‐(1–7) axis in mice
  publication-title: Cell Metab
– volume: 17
  start-page: 683
  issue: 4–5
  year: 2012
  end-page: 691
  article-title: Role of ACE2 in diastolic and systolic heart failure
  publication-title: Heart Fail Rev
– volume: 106
  start-page: 373
  issue: 2
  year: 2010
  end-page: 382
  article-title: Brain‐selective overexpression of human Angiotensin‐converting enzyme type 2 attenuates neurogenic hypertension
  publication-title: Circ Res
– volume: 203
  start-page: 631
  issue: 2
  year: 2004
  end-page: 637
  article-title: Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
  publication-title: J Pathol
– volume: 23
  start-page: 472
  issue: 4
  year: 2010
  end-page: 477
  article-title: ACE2 and angiotensin 1–7 are increased in a human model of cardiovascular hyporeactivity: pathophysiological implications
  publication-title: J Nephrol
– volume: 48
  start-page: 1
  issue: 1
  year: 2018
  end-page: 7
  article-title: Angiotensin 1–7 modulates electrophysiological characteristics and calcium homoeostasis in pulmonary veins cardiomyocytes via MAS/PI3K/eNOS signalling pathway
  publication-title: Eur J Clin Invest
– volume: 308
  start-page: H1007
  issue: 9
  year: 2015
  end-page: H1019
  article-title: Angiotensin‐(1–7) treatment mitigates right ventricular fibrosis as a distinctive feature of diabetic cardiomyopathy
  publication-title: Am J Physiol Heart Circ Physiol
– volume: 144
  start-page: 63
  year: 2020
  end-page: 65
  article-title: p38 MAPK inhibition: A promising therapeutic approach for COVID‐19
  publication-title: J Mol Cell Cardiol
– volume: 95
  start-page: 38
  issue: 1
  year: 2015
  end-page: 45
  article-title: Treatment with angiotensin‐(1–9) alleviates the cardiomyopathy in streptozotocin‐induced diabetic rats
  publication-title: Biochem Pharmacol
– volume: 585
  start-page: 273
  issue: 7824
  year: 2020
  end-page: 276
  article-title: Clinical benefit of remdesivir in rhesus macaques infected with SARS‐CoV‐2
  publication-title: Nature
– volume: 39
  start-page: 3021
  issue: 33
  year: 2018
  end-page: 3104
  article-title: 2018 ESC/ESH Guidelines for the management of arterial hypertension
  publication-title: Eur Heart J
– volume: 187
  start-page: 648
  issue: 6
  year: 2013
  end-page: 657
  article-title: Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models
  publication-title: Am J Respir Crit Care Med
– volume: 144
  start-page: 90
  year: 2017
  end-page: 99
  article-title: Azilsartan ameliorates diabetic cardiomyopathy in young db/db mice through the modulation of ACE‐2/ANG 1–7/Mas receptor cascade
  publication-title: Biochem Pharmacol
– volume: 11
  issue: 1
  year: 2020
  article-title: B38‐CAP is a bacteria‐derived ACE2‐like enzyme that suppresses hypertension and cardiac dysfunction
  publication-title: Nat Commun
– volume: 277
  start-page: 14838
  issue: 17
  year: 2002
  end-page: 14843
  article-title: Hydrolysis of biological peptides by human angiotensin‐converting enzyme‐related carboxypeptidase
  publication-title: J Biol Chem
– volume: 28
  start-page: 264
  issue: 2
  year: 2011
  end-page: 272
  article-title: Atorvastatin induced increase in homologous angiotensin I converting enzyme (ACE2) mRNA is associated to decreased fibrosis and decreased left ventricular hypertrophy in a rat model of diabetic cardiomyopathy
  publication-title: Rev Peru Med Exp Salud Publica
– volume: 97
  start-page: 180
  year: 2016
  end-page: 190
  article-title: The effects of different angiotensin II type 1 receptor blockers on the regulation of the ACE‐AngII‐AT1 and ACE2‐Ang(1–7)‐Mas axes in pressure overload‐induced cardiac remodeling in male mice
  publication-title: J Mol Cell Cardiol
– volume: 382
  issue: 25
  year: 2020
  article-title: Cardiovascular disease, drug therapy, and mortality in COVID‐19
  publication-title: N Engl J Med
– volume: 16
  start-page: 1689
  issue: 11
  year: 2014
  end-page: 1696
  article-title: Activation of angiotensin‐converting enzyme 2 improves cardiac electrical changes in ventricular repolarization in streptozotocin‐induced hyperglycaemic rats
  publication-title: Europace
– volume: 110
  issue: 4
  year: 2015
  article-title: Atrial overexpression of angiotensin‐converting enzyme 2 improves the canine rapid atrial pacing‐induced structural and electrical remodeling. Fan, ACE2 improves atrial substrate remodeling
  publication-title: Basic Res Cardiol
– volume: 59
  start-page: 1195
  issue: 6
  year: 2012
  end-page: 1203
  article-title: Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1–7 in experimental heart failure in angiotensin‐converting enzyme 2‐null mice
  publication-title: Hypertension
– volume: 2020
  year: 2019
  article-title: Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID‐19)
  publication-title: JAMA Cardiol
– volume: 395
  start-page: 497
  issue: 10223
  year: 2020
  end-page: 506
  article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan
  publication-title: China. Lancet
– volume: 395
  start-page: 1054
  issue: 10229
  year: 2020
  end-page: 1062
  article-title: Clinical course and risk factors for mortality of adult inpatients with COVID‐19 in Wuhan, China: a retrospective cohort study
  publication-title: Lancet
– volume: 87
  start-page: E1
  year: 2000
  end-page: E9
  article-title: A novel angiotensin‐converting enzyme‐related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9
  publication-title: Circ Res
– volume: 16
  start-page: 157
  issue: 2
  year: 2010
  end-page: 163
  article-title: Plasma ACE2 activity is an independent prognostic marker in Chagas' disease and equally potent as BNP
  publication-title: J Card Fail
– volume: 41
  start-page: 1818
  issue: 19
  year: 2020
  end-page: 1820
  article-title: Plasma angiotensin‐converting enzyme 2: novel biomarker in heart failure with implications for COVID‐19
  publication-title: Eur Heart J
– volume: 116
  start-page: 2218
  issue: 8
  year: 2006
  end-page: 2225
  article-title: Altered blood pressure responses and normal cardiac phenotype in ACE2‐null mice. Altered blood pressure responses and normal cardiac phenotype in ACE2‐null mice
  publication-title: J Clin Invest
– volume: 7
  start-page: 327
  issue: 2
  year: 2014
  end-page: 339
  article-title: Angiotensin 1–7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation
  publication-title: Circ Heart Fail
– volume: 110
  issue: 3
  year: 2015
  article-title: ROS and endothelial nitric oxide synthase (eNOS)‐dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes
  publication-title: Basic Res Cardiol
– volume: 59
  start-page: 739
  issue: 8
  year: 2012
  end-page: 747
  article-title: Angiotensin‐converting enzyme‐2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy
  publication-title: J Am Coll Cardiol
– volume: 2
  start-page: 446
  issue: 5
  year: 2009
  end-page: 455
  article-title: Loss of angiotensin‐converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
  publication-title: Circ Heart Fail
– volume: 95
  start-page: 601
  issue: 5
  year: 2010
  end-page: 606
  article-title: Angiotensin‐converting enzyme 2: a new target for neurogenic hypertension
  publication-title: Exp Physiol
– volume: 323
  start-page: 1061
  issue: 11
  year: 2020
  end-page: 1069
  article-title: Clinical Characteristics of 138 Hospitalized Patients With 2019 novel coronavirus‐infected pneumonia in Wuhan
  publication-title: China. JAMA
– ident: e_1_2_11_39_1
  doi: 10.1161/CIR.0000000000000659
– ident: e_1_2_11_8_1
  doi: 10.1016/S0140-6736(20)30251-8
– ident: e_1_2_11_69_1
  doi: 10.1113/EP085884
– ident: e_1_2_11_33_1
  doi: 10.1056/NEJMoa2007621
– ident: e_1_2_11_89_1
  doi: 10.1016/j.cardiores.2007.04.007
– ident: e_1_2_11_59_1
  doi: 10.1161/CIRCRESAHA.109.208645
– ident: e_1_2_11_73_1
  doi: 10.1038/srep08794
– ident: e_1_2_11_37_1
  doi: 10.1038/s41422-020-0282-0
– ident: e_1_2_11_68_1
  doi: 10.1093/europace/euu070
– ident: e_1_2_11_61_1
  doi: 10.1164/rccm.201712-2570OC
– ident: e_1_2_11_46_1
  doi: 10.1089/hum.2009.160
– ident: e_1_2_11_29_1
  doi: 10.1016/S0140-6736(20)30566-3
– ident: e_1_2_11_3_1
  doi: 10.1148/radiol.2020200370
– ident: e_1_2_11_57_1
  doi: 10.1164/rccm.201205-0880OC
– ident: e_1_2_11_62_1
  doi: 10.1113/expphysiol.2009.047407
– ident: e_1_2_11_26_1
  doi: 10.1001/jama.2020.1585
– ident: e_1_2_11_48_1
  doi: 10.1042/CS20070160
– ident: e_1_2_11_9_1
  doi: 10.1161/01.RES.87.5.e1
– ident: e_1_2_11_91_1
  doi: 10.1161/01.RES.0000187500.24964.7A
– ident: e_1_2_11_7_1
  doi: 10.1038/s41586-020-2012-7
– ident: e_1_2_11_63_1
  doi: 10.3390/ijms21124200
– ident: e_1_2_11_76_1
  doi: 10.1161/CIRCHEARTFAILURE.113.000672
– ident: e_1_2_11_92_1
  doi: 10.1038/s41467-020-14867-z
– volume: 19
  start-page: 1280
  issue: 8
  year: 2017
  ident: e_1_2_11_67_1
  article-title: Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling
  publication-title: Europace
  contributor:
    fullname: Walters TE
– ident: e_1_2_11_84_1
  doi: 10.1016/j.jacc.2008.02.088
– ident: e_1_2_11_47_1
  doi: 10.1161/HYPERTENSIONAHA.107.100693
– ident: e_1_2_11_65_1
  doi: 10.1016/S0022-2828(03)00177-9
– ident: e_1_2_11_50_1
  doi: 10.1093/eurheartj/ehy339
– ident: e_1_2_11_12_1
  doi: 10.1002/path.1570
– ident: e_1_2_11_23_1
  doi: 10.1093/eurheartj/ehaa388
– ident: e_1_2_11_25_1
  doi: 10.1016/S0140-6736(20)30183-5
– ident: e_1_2_11_75_1
  doi: 10.1016/j.bcp.2015.03.009
– ident: e_1_2_11_17_1
  doi: 10.1002/ejp.512
– ident: e_1_2_11_30_1
  doi: 10.1016/j.yjmcc.2020.05.007
– ident: e_1_2_11_86_1
  doi: 10.1016/j.cardfail.2009.09.005
– ident: e_1_2_11_13_1
  doi: 10.1152/ajpregu.00292.2006
– ident: e_1_2_11_44_1
  doi: 10.3892/etm.2014.1640
– ident: e_1_2_11_87_1
  doi: 10.1093/cvr/cvr036
– ident: e_1_2_11_81_1
  doi: 10.1590/S1726-46342011000200013
– ident: e_1_2_11_58_1
  doi: 10.1164/rccm.200811-1678OC
– ident: e_1_2_11_6_1
  doi: 10.1001/jamacardio.2020.1096
– ident: e_1_2_11_35_1
  doi: 10.1161/HYPERTENSIONAHA.120.15082
– volume: 0168
  start-page: 33675
  issue: 20
  year: 2020
  ident: e_1_2_11_36_1
  article-title: COVID‐19: Discovery, diagnostics and drug development
  publication-title: J Hepatol
  contributor:
    fullname: Asselah T
– ident: e_1_2_11_45_1
  doi: 10.1161/CIRCHEARTFAILURE.108.840124
– ident: e_1_2_11_20_1
  doi: 10.1007/s10741-011-9259-x
– ident: e_1_2_11_40_1
  doi: 10.3892/mmr.2017.6848
– ident: e_1_2_11_31_1
  doi: 10.1002/ejhf.1871
– ident: e_1_2_11_52_1
  doi: 10.1038/nature00786
– ident: e_1_2_11_70_1
  doi: 10.1111/eci.12854
– ident: e_1_2_11_2_1
– ident: e_1_2_11_85_1
  doi: 10.1016/j.cjca.2016.12.012
– ident: e_1_2_11_88_1
  doi: 10.1161/HYPERTENSIONAHA.112.191650
– ident: e_1_2_11_10_1
  doi: 10.1074/jbc.M002615200
– ident: e_1_2_11_93_1
  doi: 10.1016/j.jacc.2016.11.064
– volume: 0033
  start-page: 30080
  issue: 20
  year: 2020
  ident: e_1_2_11_28_1
  article-title: The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta‐analysis
  publication-title: Prog Cardiovasc Dis
  contributor:
    fullname: Li JW
– ident: e_1_2_11_51_1
  doi: 10.1172/JCI16980
– ident: e_1_2_11_56_1
  doi: 10.1161/HYPERTENSIONAHA.108.114322
– ident: e_1_2_11_79_1
  doi: 10.1016/j.bcp.2017.07.022
– ident: e_1_2_11_14_1
  doi: 10.1152/ajprenal.00139.2006
– ident: e_1_2_11_41_1
  doi: 10.1093/eurheartj/ehi114
– ident: e_1_2_11_74_1
  doi: 10.1152/ajpheart.00563.2014
– ident: e_1_2_11_83_1
  doi: 10.1093/eurheartj/ehaa084
– ident: e_1_2_11_15_1
  doi: 10.1074/jbc.M200581200
– ident: e_1_2_11_53_1
  doi: 10.1172/JCI16980
– ident: e_1_2_11_19_1
  doi: 10.1097/FJC.0000000000000374
– ident: e_1_2_11_38_1
  doi: 10.1038/s41586-020-2423-5
– ident: e_1_2_11_34_1
  doi: 10.1093/eurheartj/ehaa373
– ident: e_1_2_11_43_1
  doi: 10.1371/journal.pone.0061695
– ident: e_1_2_11_27_1
  doi: 10.1016/j.pcad.2020.03.001
– ident: e_1_2_11_80_1
  doi: 10.1007/s00380-016-0936-5
– volume: 2020
  start-page: e201017
  year: 2019
  ident: e_1_2_11_24_1
  article-title: Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID‐19)
  publication-title: JAMA Cardiol
  contributor:
    fullname: Guo T
– ident: e_1_2_11_82_1
  doi: 10.1016/j.pharep.2019.05.008
– ident: e_1_2_11_66_1
  doi: 10.1007/s00395-015-0499-0
– ident: e_1_2_11_54_1
  doi: 10.1161/CIRCRESAHA.113.301811
– ident: e_1_2_11_22_1
  doi: 10.1007/s00395-015-0477-6
– volume: 23
  start-page: 472
  issue: 4
  year: 2010
  ident: e_1_2_11_64_1
  article-title: ACE2 and angiotensin 1–7 are increased in a human model of cardiovascular hyporeactivity: pathophysiological implications
  publication-title: J Nephrol
  contributor:
    fullname: Calò LA
– ident: e_1_2_11_16_1
  doi: 10.1073/pnas.1432869100
– ident: e_1_2_11_94_1
  doi: 10.1016/j.lfs.2016.09.006
– ident: e_1_2_11_32_1
  doi: 10.1093/eurheartj/ehaa414
– ident: e_1_2_11_60_1
  doi: 10.1016/j.cmet.2018.04.002
– ident: e_1_2_11_4_1
  doi: 10.1136/bmj.m1091
– ident: e_1_2_11_18_1
  doi: 10.1016/j.bcp.2018.01.047
– ident: e_1_2_11_77_1
  doi: 10.1177/1753944711409281
– ident: e_1_2_11_42_1
  doi: 10.1161/01.HYP.0000237862.94083.45
– ident: e_1_2_11_55_1
  doi: 10.1161/CIRCRESAHA.116.310509
– ident: e_1_2_11_21_1
  doi: 10.1161/CIRCRESAHA.115.304110
– ident: e_1_2_11_78_1
  doi: 10.1161/CIRCRESAHA.110.227371
– ident: e_1_2_11_11_1
  doi: 10.1016/S0014-5793(02)03640-2
– volume: 28
  start-page: 148
  issue: 2
  year: 2020
  ident: e_1_2_11_5_1
  article-title: Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study
  publication-title: Zhonghua Gan Zang Bing Za Zhi
  contributor:
    fullname: Liu C
– ident: e_1_2_11_49_1
  doi: 10.3892/mmr.2017.7152
– ident: e_1_2_11_71_1
  doi: 10.3390/ijms20112833
– ident: e_1_2_11_90_1
  doi: 10.1016/j.yjmcc.2016.05.012
– ident: e_1_2_11_72_1
  doi: 10.1016/j.jacc.2011.09.071
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Snippet SARS‐CoV‐2, the virus responsible for the global coronavirus disease (COVID‐19) pandemic, attacks multiple organs of the human body by binding to...
SARS-CoV-2, the virus responsible for the global coronavirus disease (COVID-19) pandemic, attacks multiple organs of the human body by binding to...
Abstract SARS‐CoV‐2, the virus responsible for the global coronavirus disease (COVID‐19) pandemic, attacks multiple organs of the human body by binding to...
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SubjectTerms ACE2
Angiotensin
Angiotensin II
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - metabolism
Angiotensin-Converting Enzyme 2 - pharmacology
Animals
Antioxidants
Apoptosis
Arrhythmias, Cardiac - metabolism
Arrhythmias, Cardiac - physiopathology
Blood pressure
Calcium
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - complications
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Cardiovascular system
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - metabolism
COVID-19 Drug Treatment
Diminazene - pharmacology
Drugs
Enzymes
Fibrosis
Heart
Heart Failure - etiology
Humans
Hypertension
Hypertension - metabolism
Hypertension - physiopathology
Inflammation
Kinases
Myocardial Infarction - drug therapy
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Pandemics
Peptides
Proteins
RAS
Recombinant Proteins - pharmacology
Renin
Review
Reviews
SARS‐CoV‐2
Severe acute respiratory syndrome coronavirus 2
Transforming growth factor-b
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Title The role of SARS‐CoV‐2 target ACE2 in cardiovascular diseases
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