Correlation of the Osteoarthritis Susceptibility Variants That Map to Chromosome 20q13 With an Expression Quantitative Trait Locus Operating on NCOA3 and With Functional Variation at the Polymorphism rs116855380

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 67; no. 11; pp. 2923 - 2932
• Main Authors: Gee, Fiona, Rushton, Michael D., Loughlin, John, Reynard, Louise N.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2015; John Wiley and Sons Inc
• Subjects: Alleles; Cartilage, Articular - metabolism; Chromosomes, Human, Pair 20; Collagen Type II - genetics; Collagen Type II - metabolism; Core Binding Factor Alpha 1 Subunit - genetics; Core Binding Factor Alpha 1 Subunit - metabolism; Gene Expression Regulation; Genes; Genetic Predisposition to Disease; Genotype; Humans; Matrix Metalloproteinase 13 - genetics; Matrix Metalloproteinase 13 - metabolism; Nuclear Receptor Coactivator 3 - genetics; Nuclear Receptor Coactivator 3 - metabolism; Osteoarthritis; Osteoarthritis - genetics; Osteoarthritis - metabolism; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Transcription, Genetic

Objective To functionally characterize the osteoarthritis (OA) susceptibility variants that map to a region of high linkage disequilibrium (LD) on chromosome 20q13 marked by the single‐nucleotide polymorphism (SNP) rs6094710 and encompassing NCOA3 and SULF2. Methods Nucleic acids were extracted from...