Phosphonium Salts as Pseudohalides: Regioselective Nickel‐Catalyzed Cross‐Coupling of Complex Pyridines and Diazines

• Published in: Angewandte Chemie International Edition Vol. 56; no. 33; pp. 9833 - 9836
• Main Authors: Zhang, Xuan, McNally, Andrew
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 07.08.2017; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Aromatic compounds; Catalysts; Chemistry; Chemistry, Multidisciplinary; Coupling methods; Couplings; Cross coupling; diazines; Halides; Nickel; nickel catalysis; Palladium; Pharmacology; Pharmacophores; phosphonium salts; Physical Sciences; Pyridines; Regioselectivity; Salts; Science & Technology; MEDICINAL CHEMISTS TOOLBOX; diazines; pyridines; phosphonium salts; cross-coupling; LATE-STAGE FUNCTIONALIZATION; nickel catalysis

Heterobiaryls are important pharmacophores that are challenging to prepare by traditional cross‐coupling methods. An alternative approach is presented where pyridines and diazines are converted into heteroaryl phosphonium salts and coupled with aryl boronic acids. Nickel catalysts are unique for sel...