A novel epithelial‐mesenchymal transition molecular signature predicts the oncological outcomes in colorectal cancer

• Published in: Journal of cellular and molecular medicine Vol. 25; no. 7; pp. 3194 - 3204
• Main Authors: Shan, Zezhi, Wu, Wen, Yan, Xuebing, Yang, Yongzhi, Luo, Dakui, Liu, Qi, Li, Xinxiang, Goel, Ajay, Ma, Yanlei
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2021; John Wiley and Sons Inc
• Subjects: Clustering; Colorectal cancer; Colorectal carcinoma; Epithelial cells; epithelial‐Mesenchymal Transition; Gene expression; Growth factors; immunity; Lymph nodes; Medical prognosis; Mesenchyme; Metastases; Metastasis; Microenvironments; Multivariate analysis; Nomograms; Original; Patients; Principal components analysis; Prognosis; Regression analysis; risk score model; Software; Statistical analysis; Transcription factors; Tumor microenvironment; Tumors; colorectal cancer; immunity; risk score model; prognosis; epithelial-Mesenchymal Transition

Epithelial‐mesenchymal transition (EMT), a biological process involving the transformation of epithelial cells into mesenchymal cells, promotes tumour initiation and metastasis. The aim of this study was to construct an EMT molecular signature for predicting colorectal cancer (CRC) prognosis and eva...