Transition Metal‐Catalyzed Enantioselective C−H Functionalization via Chiral Transient Directing Group Strategies

• Published in: Angewandte Chemie International Edition Vol. 59; no. 45; pp. 19773 - 19786
• Main Authors: Liao, Gang, Zhang, Tao, Lin, Zhi‐Keng, Shi, Bing‐Feng
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 02.11.2020
• Edition: International ed. in English
• Subjects: asymmetric catalysis; Chemical synthesis; chiral transient directing group; C−H activation; Enantiomers; enantioselectivity; Hydrogen bonds; Natural products; Organic chemistry; total synthesis; Transition metals; enantioselectivity; C−H activation; asymmetric catalysis; total synthesis; chiral transient directing group

Transition metal‐catalyzed enantioselective functionalization of C−H bond, the most abundant functionality in organic molecules, has emerged as an expedient synthetic approach to streamline the synthesis of complex chiral molecules. Despite significant progress, traditional directing group‐enabled s...