Distinct B‐cell populations contribute to vaccine antigen‐specific antibody production in a transgenic mouse model

Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon re‐exposure to a pathogen. B‐cell populations contributing to antibody production and protection by vaccination remain poorly defined. We use...

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Published in	Immunology Vol. 142; no. 4; pp. 624 - 635
Main Authors	O, Eunju, Ko, Eun‐Ju, Kim, Min‐Chul, Lee, Young‐Tae, Song, Jae‐Min, Kwon, Young‐Man, Compans, Richard W., Kang, Sang‐Moo
Format	Journal Article
Language	English
Published	England Wiley Subscription Services, Inc 01.08.2014 Blackwell Science Inc
Subjects	Animals Antigens, Viral - immunology Antigens, Viral - pharmacology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - pathology Immunologic Memory Influenza A virus Influenza Vaccines - immunology Influenza Vaccines - pharmacology influenza virus Leukocyte Common Antigens - genetics Leukocyte Common Antigens - immunology Leukosialin - genetics Leukosialin - immunology memory B cells Mice Mice, Knockout Original Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - prevention & control plasma cells protection vaccine influenza virus vaccine protection memory B cells plasma cells
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Abstract	Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon re‐exposure to a pathogen. B‐cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus‐like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre‐derived memory B cells with the expression of yellow fluorescent protein (YFP+ cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP+ cells although vaccine antigen‐specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43+ B220− populations with low YFP+ cells mainly contributed to the production of vaccine antigen‐specific IgG isotype‐switched antibodies whereas CD43− B220+ populations with high YFP+ cells were able to produce vaccine antigen‐specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP+ cells in the B220− populations of spleen and bone marrow cells. These results suggest that CD43+ B220− B cells generated by vaccination are important for producing influenza vaccine antigen‐specific antibodies and conferring protection.
AbstractList	Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon re‐exposure to a pathogen. B‐cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus‐like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre‐derived memory B cells with the expression of yellow fluorescent protein (YFP+ cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP+ cells although vaccine antigen‐specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43+ B220− populations with low YFP+ cells mainly contributed to the production of vaccine antigen‐specific IgG isotype‐switched antibodies whereas CD43− B220+ populations with high YFP+ cells were able to produce vaccine antigen‐specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP+ cells in the B220− populations of spleen and bone marrow cells. These results suggest that CD43+ B220− B cells generated by vaccination are important for producing influenza vaccine antigen‐specific antibodies and conferring protection. The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon re-exposure to a pathogen. B-cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus-like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre-derived memory B cells with the expression of yellow fluorescent protein (YFP+ cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP+ cells although vaccine antigen-specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43+ B220- populations with low YFP+ cells mainly contributed to the production of vaccine antigen-specific IgG isotype-switched antibodies whereas CD43- B220+ populations with high YFP+ cells were able to produce vaccine antigen-specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP+ cells in the B220- populations of spleen and bone marrow cells. These results suggest that CD43+ B220- B cells generated by vaccination are important for producing influenza vaccine antigen-specific antibodies and conferring protection. Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon re-exposure to a pathogen. B-cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus-like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre-derived memory B cells with the expression of yellow fluorescent protein (YFP+ cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP+ cells although vaccine antigen-specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43+ B220- populations with low YFP+ cells mainly contributed to the production of vaccine antigen-specific IgG isotype-switched antibodies whereas CD43- B220+ populations with high YFP+ cells were able to produce vaccine antigen-specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP+ cells in the B220- populations of spleen and bone marrow cells. These results suggest that CD43+ B220- B cells generated by vaccination are important for producing influenza vaccine antigen-specific antibodies and conferring protection. [PUBLICATION ABSTRACT] Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon re‐exposure to a pathogen. B‐cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus‐like particle ( VLP ) vaccine in a transgenic mouse model that would identify germinal centre‐derived memory B cells with the expression of yellow fluorescent protein ( YFP + cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP + cells although vaccine antigen‐specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/ PR 8). In addition, CD 43 + B220 − populations with low YFP + cells mainly contributed to the production of vaccine antigen‐specific IgG isotype‐switched antibodies whereas CD 43 − B220 + populations with high YFP + cells were able to produce vaccine antigen‐specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP + cells in the B220 − populations of spleen and bone marrow cells. These results suggest that CD 43 + B220 − B cells generated by vaccination are important for producing influenza vaccine antigen‐specific antibodies and conferring protection. The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon re-exposure to a pathogen. B-cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus-like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre-derived memory B cells with the expression of yellow fluorescent protein (YFP + cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP + cells although vaccine antigen-specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43 + B220 − populations with low YFP + cells mainly contributed to the production of vaccine antigen-specific IgG isotype-switched antibodies whereas CD43 − B220 + populations with high YFP + cells were able to produce vaccine antigen-specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP + cells in the B220 − populations of spleen and bone marrow cells. These results suggest that CD43 + B220 − B cells generated by vaccination are important for producing influenza vaccine antigen-specific antibodies and conferring protection. The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon re-exposure to a pathogen. B-cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus-like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre-derived memory B cells with the expression of yellow fluorescent protein (YFP(+) cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP(+) cells although vaccine antigen-specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43(+) B220(-) populations with low YFP(+) cells mainly contributed to the production of vaccine antigen-specific IgG isotype-switched antibodies whereas CD43(-) B220(+) populations with high YFP(+) cells were able to produce vaccine antigen-specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP(+) cells in the B220(-) populations of spleen and bone marrow cells. These results suggest that CD43(+) B220(-) B cells generated by vaccination are important for producing influenza vaccine antigen-specific antibodies and conferring protection.
Author	Ko, Eun‐Ju Kim, Min‐Chul Song, Jae‐Min Lee, Young‐Tae O, Eunju Compans, Richard W. Kwon, Young‐Man Kang, Sang‐Moo
Author_xml	– sequence: 1 givenname: Eunju surname: O fullname: O, Eunju organization: Georgia State University – sequence: 2 givenname: Eun‐Ju surname: Ko fullname: Ko, Eun‐Ju organization: Georgia State University – sequence: 3 givenname: Min‐Chul surname: Kim fullname: Kim, Min‐Chul organization: Emory University School of Medicine – sequence: 4 givenname: Young‐Tae surname: Lee fullname: Lee, Young‐Tae organization: Georgia State University – sequence: 5 givenname: Jae‐Min surname: Song fullname: Song, Jae‐Min organization: Sungshin Women's University – sequence: 6 givenname: Young‐Man surname: Kwon fullname: Kwon, Young‐Man organization: Georgia State University – sequence: 7 givenname: Richard W. surname: Compans fullname: Compans, Richard W. organization: Emory University School of Medicine – sequence: 8 givenname: Sang‐Moo surname: Kang fullname: Kang, Sang‐Moo organization: Georgia State University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24645831$$D View this record in MEDLINE/PubMed
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CitedBy_id	crossref_primary_10_1111_imm_13590 crossref_primary_10_1111_sji_12288 crossref_primary_10_3389_fimmu_2017_00910 crossref_primary_10_1016_j_vaccine_2015_01_086
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Snippet	Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon... The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon... Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon...
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SubjectTerms	Animals Antigens, Viral - immunology Antigens, Viral - pharmacology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - pathology Immunologic Memory Influenza A virus Influenza Vaccines - immunology Influenza Vaccines - pharmacology influenza virus Leukocyte Common Antigens - genetics Leukocyte Common Antigens - immunology Leukosialin - genetics Leukosialin - immunology memory B cells Mice Mice, Knockout Original Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - prevention & control plasma cells protection vaccine
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Title	Distinct B‐cell populations contribute to vaccine antigen‐specific antibody production in a transgenic mouse model
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