Distinct B‐cell populations contribute to vaccine antigen‐specific antibody production in a transgenic mouse model
Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon re‐exposure to a pathogen. B‐cell populations contributing to antibody production and protection by vaccination remain poorly defined. We use...
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Published in | Immunology Vol. 142; no. 4; pp. 624 - 635 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Wiley Subscription Services, Inc
01.08.2014
Blackwell Science Inc |
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Abstract | Summary
The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon re‐exposure to a pathogen. B‐cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus‐like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre‐derived memory B cells with the expression of yellow fluorescent protein (YFP+ cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP+ cells although vaccine antigen‐specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43+ B220− populations with low YFP+ cells mainly contributed to the production of vaccine antigen‐specific IgG isotype‐switched antibodies whereas CD43− B220+ populations with high YFP+ cells were able to produce vaccine antigen‐specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP+ cells in the B220− populations of spleen and bone marrow cells. These results suggest that CD43+ B220− B cells generated by vaccination are important for producing influenza vaccine antigen‐specific antibodies and conferring protection. |
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AbstractList | Summary
The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon re‐exposure to a pathogen. B‐cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus‐like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre‐derived memory B cells with the expression of yellow fluorescent protein (YFP+ cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP+ cells although vaccine antigen‐specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43+ B220− populations with low YFP+ cells mainly contributed to the production of vaccine antigen‐specific IgG isotype‐switched antibodies whereas CD43− B220+ populations with high YFP+ cells were able to produce vaccine antigen‐specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP+ cells in the B220− populations of spleen and bone marrow cells. These results suggest that CD43+ B220− B cells generated by vaccination are important for producing influenza vaccine antigen‐specific antibodies and conferring protection. The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon re-exposure to a pathogen. B-cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus-like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre-derived memory B cells with the expression of yellow fluorescent protein (YFP+ cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP+ cells although vaccine antigen-specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43+ B220- populations with low YFP+ cells mainly contributed to the production of vaccine antigen-specific IgG isotype-switched antibodies whereas CD43- B220+ populations with high YFP+ cells were able to produce vaccine antigen-specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP+ cells in the B220- populations of spleen and bone marrow cells. These results suggest that CD43+ B220- B cells generated by vaccination are important for producing influenza vaccine antigen-specific antibodies and conferring protection. Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon re-exposure to a pathogen. B-cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus-like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre-derived memory B cells with the expression of yellow fluorescent protein (YFP+ cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP+ cells although vaccine antigen-specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43+ B220- populations with low YFP+ cells mainly contributed to the production of vaccine antigen-specific IgG isotype-switched antibodies whereas CD43- B220+ populations with high YFP+ cells were able to produce vaccine antigen-specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP+ cells in the B220- populations of spleen and bone marrow cells. These results suggest that CD43+ B220- B cells generated by vaccination are important for producing influenza vaccine antigen-specific antibodies and conferring protection. [PUBLICATION ABSTRACT] Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon re‐exposure to a pathogen. B‐cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus‐like particle ( VLP ) vaccine in a transgenic mouse model that would identify germinal centre‐derived memory B cells with the expression of yellow fluorescent protein ( YFP + cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP + cells although vaccine antigen‐specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/ PR 8). In addition, CD 43 + B220 − populations with low YFP + cells mainly contributed to the production of vaccine antigen‐specific IgG isotype‐switched antibodies whereas CD 43 − B220 + populations with high YFP + cells were able to produce vaccine antigen‐specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP + cells in the B220 − populations of spleen and bone marrow cells. These results suggest that CD 43 + B220 − B cells generated by vaccination are important for producing influenza vaccine antigen‐specific antibodies and conferring protection. The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon re-exposure to a pathogen. B-cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus-like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre-derived memory B cells with the expression of yellow fluorescent protein (YFP + cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP + cells although vaccine antigen-specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43 + B220 − populations with low YFP + cells mainly contributed to the production of vaccine antigen-specific IgG isotype-switched antibodies whereas CD43 − B220 + populations with high YFP + cells were able to produce vaccine antigen-specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP + cells in the B220 − populations of spleen and bone marrow cells. These results suggest that CD43 + B220 − B cells generated by vaccination are important for producing influenza vaccine antigen-specific antibodies and conferring protection. The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon re-exposure to a pathogen. B-cell populations contributing to antibody production and protection by vaccination remain poorly defined. We used influenza virus-like particle (VLP) vaccine in a transgenic mouse model that would identify germinal centre-derived memory B cells with the expression of yellow fluorescent protein (YFP(+) cells). Immunization with influenza VLP vaccine did not induce significant increases in YFP(+) cells although vaccine antigen-specific antibodies in sera were found to confer protection against a lethal dose of influenza A virus (A/PR8). In addition, CD43(+) B220(-) populations with low YFP(+) cells mainly contributed to the production of vaccine antigen-specific IgG isotype-switched antibodies whereas CD43(-) B220(+) populations with high YFP(+) cells were able to produce vaccine antigen-specific IgM antibodies. Challenge infection of immunized transgenic mice with live influenza A virus resulted in significant increases in YFP(+) cells in the B220(-) populations of spleen and bone marrow cells. These results suggest that CD43(+) B220(-) B cells generated by vaccination are important for producing influenza vaccine antigen-specific antibodies and conferring protection. |
Author | Ko, Eun‐Ju Kim, Min‐Chul Song, Jae‐Min Lee, Young‐Tae O, Eunju Compans, Richard W. Kwon, Young‐Man Kang, Sang‐Moo |
Author_xml | – sequence: 1 givenname: Eunju surname: O fullname: O, Eunju organization: Georgia State University – sequence: 2 givenname: Eun‐Ju surname: Ko fullname: Ko, Eun‐Ju organization: Georgia State University – sequence: 3 givenname: Min‐Chul surname: Kim fullname: Kim, Min‐Chul organization: Emory University School of Medicine – sequence: 4 givenname: Young‐Tae surname: Lee fullname: Lee, Young‐Tae organization: Georgia State University – sequence: 5 givenname: Jae‐Min surname: Song fullname: Song, Jae‐Min organization: Sungshin Women's University – sequence: 6 givenname: Young‐Man surname: Kwon fullname: Kwon, Young‐Man organization: Georgia State University – sequence: 7 givenname: Richard W. surname: Compans fullname: Compans, Richard W. organization: Emory University School of Medicine – sequence: 8 givenname: Sang‐Moo surname: Kang fullname: Kang, Sang‐Moo organization: Georgia State University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24645831$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1111_imm_13590 crossref_primary_10_1111_sji_12288 crossref_primary_10_3389_fimmu_2017_00910 crossref_primary_10_1016_j_vaccine_2015_01_086 |
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The generation of memory B cells by vaccination plays a critical role in maintaining antigen‐specific antibodies and producing antibody responses upon... The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon... Summary The generation of memory B cells by vaccination plays a critical role in maintaining antigen-specific antibodies and producing antibody responses upon... |
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SubjectTerms | Animals Antigens, Viral - immunology Antigens, Viral - pharmacology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - pathology Immunologic Memory Influenza A virus Influenza Vaccines - immunology Influenza Vaccines - pharmacology influenza virus Leukocyte Common Antigens - genetics Leukocyte Common Antigens - immunology Leukosialin - genetics Leukosialin - immunology memory B cells Mice Mice, Knockout Original Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - prevention & control plasma cells protection vaccine |
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Title | Distinct B‐cell populations contribute to vaccine antigen‐specific antibody production in a transgenic mouse model |
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