The use of Neurotrophin Therapy in the Inner Ear to Augment Cochlear Implantation Outcomes

• Published in: Anatomical record (Hoboken, N.J. : 2007) Vol. 295; no. 11; pp. 1896 - 1908
• Main Authors: Budenz, Cameron L., Pfingst, Bryan E., Raphael, Yehoash
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2012; Wiley Subscription Services, Inc
• Subjects: Animals; BDNF; Cochlea - metabolism; Cochlea - surgery; cochlear implant; Cochlear Implantation; Deafness - prevention & control; Ear, Inner - metabolism; Ear, Inner - surgery; Humans; Nerve Growth Factors - therapeutic use; neurotrophin; NT3

Severe to profound deafness is most often secondary to a loss of or injury to cochlear mechanosensory cells, and there is often an associated loss of the peripheral auditory neural structures, specifically the spiral ganglion neurons and peripheral auditory fibers. Cochlear implantation is currently...