Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with d-galactose-induced aging

• Published in: The FEBS journal Vol. 278; no. 14; pp. 2500 - 2510
• Main Authors: Zhong, Yi, Hu, Yu-Juan, Chen, Bei, Peng, Wei, Sun, Yu, Yang, Yang, Zhao, Xue-Yan, Fan, Guo-run, Huang, Xiang, Kong, Wei-Jia
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2011
• Subjects: age‐related hearing loss; Aging - drug effects; Aging - genetics; Aging - metabolism; Animals; DNA Glycosylases - genetics; DNA Glycosylases - metabolism; DNA Polymerase gamma; DNA repair; DNA Repair - drug effects; DNA Replication - drug effects; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; DNA-Binding Proteins - biosynthesis; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; Ear, Inner - drug effects; Ear, Inner - metabolism; Ear, Inner - pathology; ears; Galactose - toxicity; Gene Deletion; Gene Dosage - drug effects; Gene Expression Regulation, Developmental - drug effects; gene overexpression; Hair Cells, Auditory - drug effects; Hair Cells, Auditory - metabolism; Hair Cells, Auditory - pathology; hearing disorders; humans; Male; mitochondrial common deletion; mitochondrial DNA; Mitochondrial Proteins - biosynthesis; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; mitochondrial transcription factor A; mutation; oxidative damage; Oxidative Stress - drug effects; Presbycusis - genetics; Presbycusis - metabolism; Presbycusis - pathology; Random Allocation; Rats; Rats, Sprague-Dawley; reactive oxygen species; RNA - metabolism; transcription factors; Transcription Factors - biosynthesis; Transcription Factors - genetics; Transcription Factors - metabolism

Oxidative damage to mtDNA is associated with excessive reactive oxygen species production. The mitochondrial common deletion (mtDNA 4977-bp and 4834-bp deletion in humans and rats, respectively) is the most typical and frequent form of mtDNA damage associated with aging and degenerative diseases. Th...