Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with d-galactose-induced aging - Zhong, Yi; Hu, Yu-Juan; Chen, Bei; Peng, Wei; Sun, Yu; Yang, Yang; Zhao, Xue-Yan; Fan, Guo-run; Huang, Xiang; Kong, Wei-Jia (The FEBS journal, 2011)
Keywords: age‐related hearing loss; Aging - drug effects; Aging - genetics; Aging - metabolism; Animals; DNA Glycosylases - genetics; DNA Glycosylases - metabolism; DNA Polymerase gamma; DNA repair; DNA Repair - drug effects; DNA Replication - drug effects; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; DNA-Binding Proteins - biosynthesis; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; Ear, Inner - drug effects; Ear, Inner - metabolism; Ear, Inner - pathology; ears; Galactose - toxicity; Gene Deletion; Gene Dosage - drug effects; Gene Expression Regulation, Developmental - drug effects; gene overexpression; Hair Cells, Auditory - drug effects; Hair Cells, Auditory - metabolism; Hair Cells, Auditory - pathology; hearing disorders; humans; Male; mitochondrial common deletion; mitochondrial DNA; Mitochondrial Proteins - biosynthesis; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; mitochondrial transcription factor A; mutation; oxidative damage; Oxidative Stress - drug effects; Presbycusis - genetics; Presbycusis - metabolism; Presbycusis - pathology; Random Allocation; Rats; Rats, Sprague-Dawley; reactive oxygen species; RNA - metabolism; transcription factors; Transcription Factors - biosynthesis; Transcription Factors - genetics; Transcription Factors - metabolism