FeOOH@Metal–Organic Framework Core–Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers

• Published in: Angewandte Chemie International Edition Vol. 59; no. 27; pp. 10831 - 10835
• Main Authors: Pei, Congcong, Liu, Chao, Wang, You, Cheng, Dan, Li, Rongxin, Shu, Weikang, Zhang, Chaoqi, Hu, Wenli, Jin, Aihua, Yang, Yannan, Wan, Jingjing
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 26.06.2020
• Edition: International ed. in English
• Subjects: Cancer; diagnostics; Female; Ferric Compounds - chemistry; Fingerprinting; Fingerprints; Genital Neoplasms, Female - blood; Gynecological cancer; gynecological cancers; Gynecology; Humans; Ionization; Ions; Mass spectrometry; Mass spectroscopy; Metabolism; metabolites; Metabolome; Metal-organic frameworks; Metal-Organic Frameworks - chemistry; Microscopy, Electron - methods; Nanocomposites; Nanocomposites - chemistry; Pretreatment; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; Spectroscopy, Fourier Transform Infrared - methods; mass spectrometry; diagnostics; gynecological cancers; metabolites; metal-organic frameworks

High‐throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we designed FeOOH@ZIF‐8 composites with enhanced ionization efficiency and size‐exclusion effect for laser desorption/ionization mass spectrome...