FeOOH@Metal–Organic Framework Core–Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers
High‐throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we designed FeOOH@ZIF‐8 composites with enhanced ionization efficiency and size‐exclusion effect for laser desorption/ionization mass spectrome...
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| Published in | Angewandte Chemie International Edition Vol. 59; no. 27; pp. 10831 - 10835 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Wiley Subscription Services, Inc
26.06.2020
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| Edition | International ed. in English |
| Subjects | |
| Online Access | Get full text |
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| Abstract | High‐throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we designed FeOOH@ZIF‐8 composites with enhanced ionization efficiency and size‐exclusion effect for laser desorption/ionization mass spectrometry (LDI‐MS)‐based metabolic diagnosis of gynecological cancers. The FeOOH@ZIF‐8‐assisted LDI‐MS achieved rapid, sensitive, and selective metabolic fingerprints of the native serum without any enrichment or purification. Further analysis of extracted serum metabolic fingerprints successfully discriminated patients with gynecological cancers (GCs) from healthy controls and also differentiated three major subtypes of GCs. Given the low cost, high‐throughput, and easy operation, our approach brings a new dimension to disease analysis and classification.
FeOOH@ZIF‐8 composites display enhanced ionization efficiency and size‐exclusion effect, enabling fast, sensitive, and selective LDI‐MS analysis of small metabolites in serum (1 μL) without pretreatment. Based on the extracted metabolic fingerprints, patients with three major gynecological cancers (ovarian, cervical, and endometrial cancer) were differentiated from healthy controls with high specificity and sensitivity. |
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| AbstractList | High‐throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we designed FeOOH@ZIF‐8 composites with enhanced ionization efficiency and size‐exclusion effect for laser desorption/ionization mass spectrometry (LDI‐MS)‐based metabolic diagnosis of gynecological cancers. The FeOOH@ZIF‐8‐assisted LDI‐MS achieved rapid, sensitive, and selective metabolic fingerprints of the native serum without any enrichment or purification. Further analysis of extracted serum metabolic fingerprints successfully discriminated patients with gynecological cancers (GCs) from healthy controls and also differentiated three major subtypes of GCs. Given the low cost, high‐throughput, and easy operation, our approach brings a new dimension to disease analysis and classification. High-throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we designed FeOOH@ZIF-8 composites with enhanced ionization efficiency and size-exclusion effect for laser desorption/ionization mass spectrometry (LDI-MS)-based metabolic diagnosis of gynecological cancers. The FeOOH@ZIF-8-assisted LDI-MS achieved rapid, sensitive, and selective metabolic fingerprints of the native serum without any enrichment or purification. Further analysis of extracted serum metabolic fingerprints successfully discriminated patients with gynecological cancers (GCs) from healthy controls and also differentiated three major subtypes of GCs. Given the low cost, high-throughput, and easy operation, our approach brings a new dimension to disease analysis and classification.High-throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we designed FeOOH@ZIF-8 composites with enhanced ionization efficiency and size-exclusion effect for laser desorption/ionization mass spectrometry (LDI-MS)-based metabolic diagnosis of gynecological cancers. The FeOOH@ZIF-8-assisted LDI-MS achieved rapid, sensitive, and selective metabolic fingerprints of the native serum without any enrichment or purification. Further analysis of extracted serum metabolic fingerprints successfully discriminated patients with gynecological cancers (GCs) from healthy controls and also differentiated three major subtypes of GCs. Given the low cost, high-throughput, and easy operation, our approach brings a new dimension to disease analysis and classification. High‐throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we designed FeOOH@ZIF‐8 composites with enhanced ionization efficiency and size‐exclusion effect for laser desorption/ionization mass spectrometry (LDI‐MS)‐based metabolic diagnosis of gynecological cancers. The FeOOH@ZIF‐8‐assisted LDI‐MS achieved rapid, sensitive, and selective metabolic fingerprints of the native serum without any enrichment or purification. Further analysis of extracted serum metabolic fingerprints successfully discriminated patients with gynecological cancers (GCs) from healthy controls and also differentiated three major subtypes of GCs. Given the low cost, high‐throughput, and easy operation, our approach brings a new dimension to disease analysis and classification. FeOOH@ZIF‐8 composites display enhanced ionization efficiency and size‐exclusion effect, enabling fast, sensitive, and selective LDI‐MS analysis of small metabolites in serum (1 μL) without pretreatment. Based on the extracted metabolic fingerprints, patients with three major gynecological cancers (ovarian, cervical, and endometrial cancer) were differentiated from healthy controls with high specificity and sensitivity. |
| Author | Liu, Chao Li, Rongxin Hu, Wenli Pei, Congcong Wang, You Wan, Jingjing Jin, Aihua Zhang, Chaoqi Cheng, Dan Yang, Yannan Shu, Weikang |
| Author_xml | – sequence: 1 givenname: Congcong surname: Pei fullname: Pei, Congcong organization: East China Normal University – sequence: 2 givenname: Chao surname: Liu fullname: Liu, Chao organization: East China Normal University – sequence: 3 givenname: You surname: Wang fullname: Wang, You organization: Shanghai Jiao Tong University – sequence: 4 givenname: Dan surname: Cheng fullname: Cheng, Dan organization: The University of Queensland – sequence: 5 givenname: Rongxin surname: Li fullname: Li, Rongxin organization: East China Normal University – sequence: 6 givenname: Weikang surname: Shu fullname: Shu, Weikang organization: East China Normal University – sequence: 7 givenname: Chaoqi surname: Zhang fullname: Zhang, Chaoqi organization: East China Normal University – sequence: 8 givenname: Wenli surname: Hu fullname: Hu, Wenli organization: East China Normal University – sequence: 9 givenname: Aihua surname: Jin fullname: Jin, Aihua organization: The University of Queensland – sequence: 10 givenname: Yannan surname: Yang fullname: Yang, Yannan organization: The University of Queensland – sequence: 11 givenname: Jingjing orcidid: 0000-0001-9324-2647 surname: Wan fullname: Wan, Jingjing email: jjwan@chem.ecnu.edu.cn organization: East China Normal University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32237260$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1039/C7SC00937B 10.1373/clinchem.2012.184598 10.1038/nchem.1272 10.1002/ange.201205436 10.1016/j.apcatb.2018.09.036 10.1039/c3cc40934a 10.1016/j.aca.2016.06.026 10.1002/ijc.29010 10.1002/adfm.201504184 10.1016/j.ygyno.2011.12.435 10.1002/adfm.201801730 10.1016/j.cca.2015.03.005 10.1002/ange.200905579 10.1093/annonc/mdq597 10.1021/pr400337b 10.1038/nature06195 10.1016/j.ygyno.2014.06.003 10.1126/science.1243259 10.1002/adfm.201903609 10.1039/C5CC02495A 10.1021/ac0713510 10.1038/s41467-020-15487-3 10.1002/smll.201803051 10.1021/am501291d 10.1039/C9CC00384C 10.1002/anie.200905579 10.1021/acscentsci.7b00546 10.1038/s41467-017-00220-4 10.1039/C0CS00050G 10.1016/j.matt.2019.08.014 10.1039/C5NR00244C 10.1039/C6CC07371A 10.1002/ange.201207348 10.1002/viw2.6 10.1039/C6RA00877A 10.1002/biot.201900262 10.1039/C6AN02165D 10.1002/anie.201913065 10.1016/j.talanta.2018.09.024 10.1126/science.aar3247 10.1007/s13277-015-4164-x 10.1002/chem.201800994 10.1021/cr010375i 10.1007/s11306-019-1609-z 10.1016/j.aca.2015.07.029 10.1038/ncomms14524 10.1136/gutjnl-2016-312432 10.1002/viw2.1 10.1021/ja106276j 10.1002/smtd.201900469 10.1007/s13361-014-1010-0 10.1016/j.cmet.2019.01.011 10.1002/anie.201207348 10.1002/smtd.201700196 10.1016/S0022-3999(98)00014-2 10.1021/am3027025 10.1002/jms.1385 10.1021/acsami.8b17051 10.1002/anie.201205436 10.1016/j.aca.2009.03.039 10.3389/fendo.2018.00087 10.1073/pnas.1704961114 10.1007/s11306-007-0099-6 10.1002/ange.201913065 10.1038/nature13110 10.1021/cr010376a 10.1002/prca.201500055 |
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| Keywords | mass spectrometry diagnostics gynecological cancers metabolites metal-organic frameworks |
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| References | 2017; 8 2017; 1 2012; 124 2019; 55 2019; 15 2020 2020; 59 132 2020; 15 2020; 11 2008; 4 2013; 5 2017; 114 2016; 37 1998; 45 2014; 134 2013 2013; 52 125 2019; 241 2018; 9 2013; 59 2020; 4 2020; 1 2018; 4 2015; 136 2013; 12 2012 2012; 51 124 2016; 113 2011; 22 2019; 29 2014; 6 2018; 28 2007; 449 2019; 192 2013; 49 2015; 445 2015; 51 2019; 1 2011; 40 2016; 10 2013; 342 2009; 650 2016; 52 2010 2010; 49 122 2015; 888 2018; 67 2015; 7 2018; 24 2016; 6 2015; 26 2014; 508 2018; 359 2020 2016; 937 2010; 132 2008; 43 2017; 142 2005; 50 2003; 103 2018; 10 2012; 4 2016; 26 2008; 80 e_1_2_2_24_2 e_1_2_2_47_2 e_1_2_2_4_2 e_1_2_2_49_1 e_1_2_2_6_1 e_1_2_2_22_2 e_1_2_2_2_1 e_1_2_2_62_2 e_1_2_2_41_2 e_1_2_2_64_2 e_1_2_2_41_3 e_1_2_2_8_2 e_1_2_2_28_2 e_1_2_2_43_2 e_1_2_2_66_2 e_1_2_2_45_2 e_1_2_2_26_1 e_1_2_2_68_1 e_1_2_2_81_2 e_1_2_2_83_1 e_1_2_2_60_1 Chaleckis R. (e_1_2_2_40_2) 2016; 113 e_1_2_2_13_2 e_1_2_2_59_2 e_1_2_2_38_2 e_1_2_2_11_1 e_1_2_2_51_2 e_1_2_2_72_2 e_1_2_2_19_2 e_1_2_2_30_2 Liu J. (e_1_2_2_20_2) 2020 e_1_2_2_53_1 e_1_2_2_74_1 e_1_2_2_17_2 e_1_2_2_32_2 e_1_2_2_55_2 e_1_2_2_32_3 e_1_2_2_34_2 e_1_2_2_57_2 e_1_2_2_76_2 e_1_2_2_15_1 e_1_2_2_36_1 e_1_2_2_78_1 e_1_2_2_70_1 e_1_2_2_3_2 e_1_2_2_5_1 e_1_2_2_23_2 e_1_2_2_48_2 e_1_2_2_21_1 e_1_2_2_1_1 e_1_2_2_61_2 e_1_2_2_42_1 e_1_2_2_65_1 e_1_2_2_84_1 e_1_2_2_29_2 e_1_2_2_63_2 e_1_2_2_7_2 e_1_2_2_27_3 e_1_2_2_27_2 e_1_2_2_44_2 e_1_2_2_69_1 e_1_2_2_9_2 e_1_2_2_25_2 e_1_2_2_46_2 e_1_2_2_67_2 e_1_2_2_82_2 e_1_2_2_80_1 e_1_2_2_35_3 e_1_2_2_12_2 e_1_2_2_37_2 e_1_2_2_58_2 e_1_2_2_39_1 e_1_2_2_10_2 e_1_2_2_50_2 e_1_2_2_75_2 e_1_2_2_31_1 e_1_2_2_18_2 e_1_2_2_52_2 e_1_2_2_73_2 Powell J. L. (e_1_2_2_14_2) 2005; 50 e_1_2_2_56_1 e_1_2_2_79_1 e_1_2_2_16_2 e_1_2_2_33_2 e_1_2_2_54_2 e_1_2_2_35_2 e_1_2_2_77_2 e_1_2_2_71_1 |
| References_xml | – volume: 51 124 start-page: 10386 10532 year: 2012 2012 end-page: 10389 10535 publication-title: Angew. Chem. Int. Ed. Angew. Chem. – volume: 52 125 start-page: 3650 3738 year: 2013 2013 end-page: 3653 3741 publication-title: Angew. Chem. Int. Ed. Angew. Chem. – volume: 37 start-page: 5485 year: 2016 end-page: 5492 publication-title: Tumor Biol. – volume: 9 start-page: 87 year: 2018 publication-title: Front. Endocrinol. – volume: 8 start-page: 14524 year: 2017 publication-title: Nat. Commun. – volume: 49 start-page: 4929 year: 2013 end-page: 4931 publication-title: Chem. Commun. – volume: 6 start-page: 23790 year: 2016 end-page: 23793 publication-title: RSC Adv. – volume: 134 start-page: 393 year: 2014 end-page: 402 publication-title: Gynecol. Oncol. – volume: 359 start-page: 926 year: 2018 end-page: 930 publication-title: Science – volume: 888 start-page: 103 year: 2015 end-page: 109 publication-title: Anal. Chim. Acta – volume: 43 start-page: 1063 year: 2008 end-page: 1071 publication-title: J. Mass Spectrom. – volume: 114 start-page: 10202 year: 2017 end-page: 10207 publication-title: Proc. Natl. Acad. Sci. USA – volume: 45 start-page: 201 year: 1998 end-page: 214 publication-title: J. Psychosom. Res. – volume: 650 start-page: 3 year: 2009 end-page: 9 publication-title: Anal. Chim. Acta – volume: 29 year: 2019 publication-title: Adv. Funct. Mater. – volume: 12 start-page: 3000 year: 2013 end-page: 3009 publication-title: J. Proteome Res. – volume: 26 start-page: 149 year: 2015 end-page: 158 publication-title: J. Am. Soc. Mass Spectrom. – volume: 508 start-page: 108 year: 2014 end-page: 112 publication-title: Nature – volume: 28 year: 2018 publication-title: Adv. Funct. Mater. – volume: 1 start-page: 1669 year: 2019 end-page: 1680 publication-title: Matter – year: 2020 publication-title: Adv. Sci. – volume: 342 year: 2013 publication-title: Science – volume: 51 start-page: 8785 year: 2015 end-page: 8788 publication-title: Chem. Commun. – volume: 55 start-page: 3745 year: 2019 end-page: 3748 publication-title: Chem. Commun. – volume: 24 start-page: 9598 year: 2018 end-page: 9605 publication-title: Chem. Eur. J. – volume: 29 start-page: 1217 year: 2019 end-page: 1231 publication-title: Cell Metab. – volume: 8 start-page: 3926 year: 2017 end-page: 3938 publication-title: Chem. Sci. – volume: 40 start-page: 1269 year: 2011 end-page: 1281 publication-title: Chem. Soc. Rev. – volume: 136 start-page: 516 year: 2015 end-page: 526 publication-title: Int. J. Cancer – volume: 103 start-page: 395 year: 2003 end-page: 426 publication-title: Chem. Rev. – volume: 80 start-page: 115 year: 2008 end-page: 122 publication-title: Anal. Chem. – volume: 6 start-page: 8387 year: 2014 end-page: 8395 publication-title: ACS Appl. Mater. Interfaces – volume: 67 start-page: 128 year: 2018 end-page: 137 publication-title: Gut – volume: 142 start-page: 586 year: 2017 end-page: 590 publication-title: Analyst – volume: 4 start-page: 310 year: 2012 end-page: 316 publication-title: Nat. Chem. – volume: 124 start-page: 417 year: 2012 end-page: 425 publication-title: Gynecol. Oncol. – volume: 11 start-page: 1654 year: 2020 end-page: 1654 publication-title: Nat. Commun. – volume: 15 year: 2019 publication-title: Small – volume: 5 start-page: 1024 year: 2013 end-page: 1030 publication-title: ACS Appl. Mater. Interfaces – volume: 7 start-page: 6487 year: 2015 end-page: 6491 publication-title: Nanoscale – volume: 1 year: 2017 publication-title: Small Methods – volume: 449 start-page: 1033 year: 2007 publication-title: Nature – volume: 937 start-page: 87 year: 2016 end-page: 95 publication-title: Anal. Chim. Acta – volume: 59 132 start-page: 1703 1720 year: 2020 2020 end-page: 1710 1727 publication-title: Angew. Chem. Int. Ed. Angew. Chem. – volume: 10 start-page: 44751 year: 2018 end-page: 44759 publication-title: ACS Appl. Mater. Interfaces – volume: 15 start-page: 146 year: 2019 publication-title: Metabolomics – volume: 49 122 start-page: 5426 5554 year: 2010 2010 end-page: 5445 5575 publication-title: Angew. Chem. Int. Ed. Angew. Chem. – volume: 8 start-page: 220 year: 2017 publication-title: Nat. Commun. – volume: 103 start-page: 427 year: 2003 end-page: 440 publication-title: Chem. Rev. – volume: 15 year: 2020 publication-title: Biotechnol. J. – volume: 113 start-page: 4252 year: 2016 end-page: 4259 publication-title: Asian Pac. J. Cancer Prev. – volume: 59 start-page: 138 year: 2013 end-page: 146 publication-title: Clin. Chem. – volume: 4 year: 2020 publication-title: Small Methods – volume: 4 start-page: 223 year: 2018 end-page: 229 publication-title: ACS Cent. Sci. – volume: 50 start-page: 585 year: 2005 end-page: 590 publication-title: J. Reprod. Med. – volume: 22 start-page: 1339 year: 2011 end-page: 1345 publication-title: Ann. Oncol. – volume: 26 start-page: 4016 year: 2016 end-page: 4025 publication-title: Adv. Funct. Mater. – volume: 52 start-page: 12984 year: 2016 end-page: 12987 publication-title: Chem. Commun. – volume: 132 start-page: 14714 year: 2010 end-page: 14717 publication-title: J. Am. Chem. Soc. – volume: 192 start-page: 79 year: 2019 end-page: 85 publication-title: Talanta – volume: 445 start-page: 7 year: 2015 end-page: 11 publication-title: Clin. Chim. Acta – volume: 4 start-page: 81 year: 2008 end-page: 89 publication-title: Metabolomics – volume: 10 start-page: 217 year: 2016 end-page: 229 publication-title: Proteomics Clin. Appl. – volume: 1 year: 2020 publication-title: View – volume: 241 start-page: 149 year: 2019 end-page: 158 publication-title: Appl. Catal. B – ident: e_1_2_2_62_2 doi: 10.1039/C7SC00937B – ident: e_1_2_2_16_2 doi: 10.1373/clinchem.2012.184598 – ident: e_1_2_2_69_1 doi: 10.1038/nchem.1272 – ident: e_1_2_2_32_3 doi: 10.1002/ange.201205436 – ident: e_1_2_2_31_1 – ident: e_1_2_2_80_1 – ident: e_1_2_2_70_1 doi: 10.1016/j.apcatb.2018.09.036 – ident: e_1_2_2_54_2 doi: 10.1039/c3cc40934a – year: 2020 ident: e_1_2_2_20_2 publication-title: Adv. Sci. – ident: e_1_2_2_66_2 doi: 10.1016/j.aca.2016.06.026 – ident: e_1_2_2_4_2 doi: 10.1002/ijc.29010 – ident: e_1_2_2_15_1 – ident: e_1_2_2_46_2 doi: 10.1002/adfm.201504184 – volume: 50 start-page: 585 year: 2005 ident: e_1_2_2_14_2 publication-title: J. Reprod. Med. – ident: e_1_2_2_3_2 doi: 10.1016/j.ygyno.2011.12.435 – ident: e_1_2_2_48_2 doi: 10.1002/adfm.201801730 – ident: e_1_2_2_12_2 doi: 10.1016/j.cca.2015.03.005 – ident: e_1_2_2_11_1 – ident: e_1_2_2_27_3 doi: 10.1002/ange.200905579 – ident: e_1_2_2_22_2 doi: 10.1093/annonc/mdq597 – ident: e_1_2_2_82_2 doi: 10.1021/pr400337b – ident: e_1_2_2_43_2 doi: 10.1038/nature06195 – ident: e_1_2_2_5_1 doi: 10.1016/j.ygyno.2014.06.003 – ident: e_1_2_2_28_2 doi: 10.1126/science.1243259 – ident: e_1_2_2_36_1 – ident: e_1_2_2_37_2 doi: 10.1002/adfm.201903609 – ident: e_1_2_2_57_2 doi: 10.1039/C5CC02495A – ident: e_1_2_2_83_1 doi: 10.1021/ac0713510 – volume: 113 start-page: 4252 year: 2016 ident: e_1_2_2_40_2 publication-title: Asian Pac. J. Cancer Prev. – ident: e_1_2_2_6_1 – ident: e_1_2_2_9_2 doi: 10.1038/s41467-020-15487-3 – ident: e_1_2_2_34_2 doi: 10.1002/smll.201803051 – ident: e_1_2_2_60_1 – ident: e_1_2_2_61_2 doi: 10.1021/am501291d – ident: e_1_2_2_39_1 – ident: e_1_2_2_71_1 – ident: e_1_2_2_49_1 – ident: e_1_2_2_64_2 doi: 10.1039/C9CC00384C – ident: e_1_2_2_27_2 doi: 10.1002/anie.200905579 – ident: e_1_2_2_74_1 – ident: e_1_2_2_47_2 doi: 10.1021/acscentsci.7b00546 – ident: e_1_2_2_29_2 doi: 10.1038/s41467-017-00220-4 – ident: e_1_2_2_38_2 doi: 10.1039/C0CS00050G – ident: e_1_2_2_67_2 doi: 10.1016/j.matt.2019.08.014 – ident: e_1_2_2_58_2 doi: 10.1039/C5NR00244C – ident: e_1_2_2_59_2 doi: 10.1039/C6CC07371A – ident: e_1_2_2_35_3 doi: 10.1002/ange.201207348 – ident: e_1_2_2_52_2 doi: 10.1002/viw2.6 – ident: e_1_2_2_78_1 doi: 10.1039/C6RA00877A – ident: e_1_2_2_19_2 doi: 10.1002/biot.201900262 – ident: e_1_2_2_76_2 doi: 10.1039/C6AN02165D – ident: e_1_2_2_65_1 – ident: e_1_2_2_41_2 doi: 10.1002/anie.201913065 – ident: e_1_2_2_75_2 doi: 10.1016/j.talanta.2018.09.024 – ident: e_1_2_2_8_2 doi: 10.1126/science.aar3247 – ident: e_1_2_2_42_1 – ident: e_1_2_2_23_2 doi: 10.1007/s13277-015-4164-x – ident: e_1_2_2_68_1 doi: 10.1002/chem.201800994 – ident: e_1_2_2_72_2 doi: 10.1021/cr010375i – ident: e_1_2_2_25_2 doi: 10.1007/s11306-019-1609-z – ident: e_1_2_2_55_2 doi: 10.1016/j.aca.2015.07.029 – ident: e_1_2_2_77_2 doi: 10.1038/ncomms14524 – ident: e_1_2_2_26_1 – ident: e_1_2_2_33_2 doi: 10.1136/gutjnl-2016-312432 – ident: e_1_2_2_10_2 doi: 10.1002/viw2.1 – ident: e_1_2_2_56_1 – ident: e_1_2_2_53_1 – ident: e_1_2_2_45_2 doi: 10.1021/ja106276j – ident: e_1_2_2_44_2 doi: 10.1002/smtd.201900469 – ident: e_1_2_2_84_1 doi: 10.1007/s13361-014-1010-0 – ident: e_1_2_2_18_2 doi: 10.1016/j.cmet.2019.01.011 – ident: e_1_2_2_35_2 doi: 10.1002/anie.201207348 – ident: e_1_2_2_30_2 doi: 10.1002/smtd.201700196 – ident: e_1_2_2_1_1 doi: 10.1016/S0022-3999(98)00014-2 – ident: e_1_2_2_50_2 doi: 10.1021/am3027025 – ident: e_1_2_2_51_2 doi: 10.1002/jms.1385 – ident: e_1_2_2_63_2 doi: 10.1021/acsami.8b17051 – ident: e_1_2_2_32_2 doi: 10.1002/anie.201205436 – ident: e_1_2_2_81_2 doi: 10.1016/j.aca.2009.03.039 – ident: e_1_2_2_24_2 doi: 10.3389/fendo.2018.00087 – ident: e_1_2_2_7_2 doi: 10.1073/pnas.1704961114 – ident: e_1_2_2_79_1 doi: 10.1007/s11306-007-0099-6 – ident: e_1_2_2_2_1 – ident: e_1_2_2_41_3 doi: 10.1002/ange.201913065 – ident: e_1_2_2_17_2 doi: 10.1038/nature13110 – ident: e_1_2_2_73_2 doi: 10.1021/cr010376a – ident: e_1_2_2_21_1 – ident: e_1_2_2_13_2 doi: 10.1002/prca.201500055 |
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| Snippet | High‐throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we... High-throughput metabolic analysis is of significance in diagnostics, while tedious sample pretreatment has largely hindered its clinic application. Herein, we... |
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| SubjectTerms | Cancer diagnostics Female Ferric Compounds - chemistry Fingerprinting Fingerprints Genital Neoplasms, Female - blood Gynecological cancer gynecological cancers Gynecology Humans Ionization Ions Mass spectrometry Mass spectroscopy Metabolism metabolites Metabolome Metal-organic frameworks Metal-Organic Frameworks - chemistry Microscopy, Electron - methods Nanocomposites Nanocomposites - chemistry Pretreatment Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectroscopy, Fourier Transform Infrared - methods |
| Title | FeOOH@Metal–Organic Framework Core–Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers |
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