Component‐resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness

• Published in: Allergy (Copenhagen) Vol. 71; no. 11; pp. 1552 - 1560
• Main Authors: Wright, B. L., Kulis, M., Orgel, K. A., Burks, A. W., Dawson, P., Henning, A. K., Jones, S. M., Wood, R. A., Sicherer, S. H., Lindblad, R. W., Stablein, D., Leung, D. Y. M., Vickery, B. P., Sampson, H. A.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.11.2016
• Subjects: Administration, Oral; Allergens - administration & dosage; Allergens - immunology; Biomarkers; component testing; Desensitization, Immunologic - methods; egg allergy; Egg Hypersensitivity - immunology; Egg Hypersensitivity - therapy; Eggs - adverse effects; Female; food allergy; Humans; IgA; Immunoglobulin A - blood; Immunoglobulin A - immunology; Immunoglobulin E - blood; Immunoglobulin E - immunology; Immunoglobulin G - blood; Immunoglobulin G - immunology; Male; oral immunotherapy; Treatment Failure; Treatment Outcome; IgA; oral immunotherapy; egg allergy; component testing; food allergy

Background In a previously reported CoFAR study, 55 subjects with egg allergy underwent randomized, placebo‐controlled egg oral immunotherapy (eOIT). Active treatment induced desensitization in most and sustained unresponsiveness (SU) in a smaller subset. We hypothesized that component‐resolved anal...