Nonclinical Safety Assessment of Morus alba L. Fruits: Study of 90-D Toxicity in Sprague Dawley Rats and Genotoxicity in Salmonella

• Published in: Journal of food science Vol. 81; no. 5; pp. T1328 - T1335
• Main Authors: Chang, Bo Yoon, Kim, Seon Beom, Lee, Mi Kyeong, Park, Hyun, Kim, Sung Yeon
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.05.2016; Wiley Subscription Services, Inc
• Subjects: Administration, Oral; Animals; Assessments; DNA Damage; Female; Fruit; Fruits; Genotoxicity; herbal safety; Male; Morus; Morus alba; Morus alba L. fruit; Mutagenicity Tests; No-Observed-Adverse-Effect Level; Organ Size - drug effects; Plant Extracts - pharmacology; Plant Extracts - toxicity; Rats; Rats, Sprague-Dawley; Rodents; Safety; Salmonella; Salmonella typhimurium; Salmonella typhimurium - drug effects; Salmonella typhimurium - genetics; SD rat; Strain; subchronic toxicity; Toxicity; Toxicity Tests, Subchronic; genotoxicity; subchronic toxicity; herbal safety; SD rat; Morus alba L. fruit

Morus alba L. is a traditional herb with a long history of consumption, both as an edible fruit and as medicine. However, its safety evaluation has not yet been established. The objective of this study was to evaluate subchronic oral toxicity and genotoxicity of M. alba L. fruits (MFE). The subchron...