Red Light‐Triggered Intracellular Carbon Monoxide Release Enables Selective Eradication of MRSA Infection

• Published in: Angewandte Chemie International Edition Vol. 60; no. 24; pp. 13513 - 13520
• Main Authors: Cheng, Jian, Gan, Guihai, Shen, Zhiqiang, Gao, Lei, Zhang, Guoying, Hu, Jinming
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 07.06.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: antibacterial agents; Antiinfectives and antibacterials; Antimicrobial activity; Carbon monoxide; Carbonyl compounds; Carbonyls; Chemistry; Chemistry, Multidisciplinary; Drug resistance; E coli; Gram-negative bacteria; Irradiation; Light irradiation; Metal carbonyls; Metals; Methicillin; Micelles; MRSA; photooxidation; Physical Sciences; Releasing; Science & Technology; Staphylococcus aureus; Transition metals; Wound healing; carbon monoxide; wound healing; photooxidation; antibacterial agents; MRSA

Carbon monoxide (CO) is an important gaseous signaling molecule. The use of CO‐releasing molecules such as metal carbonyls enables the elucidation of the pleiotropic functions of CO. Although metal carbonyls show a broad‐spectrum antimicrobial activity, it remains unclear whether the bactericidal pr...