Evidence for the Prerequisite Formation of Phenoxyl Radicals in Radical‐Mediated Peptide Tyrosine Nitration In Vacuo

• Published in: Chemistry : a European journal Vol. 26; no. 1; pp. 331 - 335
• Main Authors: Lai, Cheuk Kuen, Tang, Wai Kit, Siu, Chi‐Kit, Chu, Ivan K.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 02.01.2020
• Subjects: Cations; Chemical synthesis; Chemistry; isomerization; Isotopic labeling; Nitration; Nitrogen dioxide; Peptides; Phenolic compounds; Phenols; radical reactions; reaction mechanisms; Recombination; Regioselectivity; Tyrosine; Vapor phases; regioselectivity; radical reactions; reaction mechanisms; isomerization; nitration

The elementary mechanism of radical‐mediated peptide tyrosine nitration, which is a hallmark of post‐translational modification of proteins under nitrative stress in vivo, has been elucidated in detail by using an integrated approach that combines the gas‐phase synthesis of prototypical molecular ty...