A Reversible Fluorescent Probe for Real‐Time Quantitative Monitoring of Cellular Glutathione

• Published in: Angewandte Chemie International Edition Vol. 56; no. 21; pp. 5812 - 5816
• Main Authors: Liu, Zhixue, Zhou, Xin, Miao, Yu, Hu, Ying, Kwon, Nahyun, Wu, Xue, Yoon, Juyoung
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 15.05.2017; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: antioxidants; Chemistry; Chemistry, Multidisciplinary; Cytotoxicity; Fluorescence; Fluorescent indicators; fluorescent probes; Glutathione; gluthionine; Monitoring; Physical Sciences; ratiometric probes; redox homeostasis; Response time; Science & Technology; Toxicity; CELLS; antioxidants; ASSISTED ELECTROSTATIC ATTRACTION; CYSTEINE; SENSOR; redox homeostasis; fluorescent probes; gluthionine; MICHAEL ADDITION; THIOLS; IN-VIVO; EMISSION CHANNELS; ratiometric probes; SELECTIVE DETECTION; GSH

The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH‐related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have dev...