A Reversible Fluorescent Probe for Real‐Time Quantitative Monitoring of Cellular Glutathione
The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH‐related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have dev...
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| Published in | Angewandte Chemie International Edition Vol. 56; no. 21; pp. 5812 - 5816 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
WEINHEIM
Wiley
15.05.2017
Wiley Subscription Services, Inc |
| Edition | International ed. in English |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH‐related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed a ratiometric fluorescent probe (QG‐1) for quantitatively monitoring cellular GSH. The probe responds specifically and reversibility to GSH with an ideal dissociation constant (Kd) of 2.59 mm and a fast response time (t1/2=5.82 s). We also demonstrate that QG‐1 detection of GSH is feasible in a model protein system. QG‐1 was found to have extremely low cytotoxicity and was applied to determine the GSH concentration in live HeLa cells (5.40±0.87 mm).
Given the green light: A ratiometric fluorescent probe (QG‐1) for monitoring and quantifying variations in cellular glutathione (GSH) was developed. The probe shows a fluorescence shift from red to green upon binding GSH and exhibits specificity and reversibility, with an appropriate dissociation constant for sensing species with high cellular abundance (Kd=2.59 mm) and a fast response time (t1/2=5.82 s). |
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| AbstractList | The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH-related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed a ratiometric fluorescent probe (QG-1) for quantitatively monitoring cellular GSH. The probe responds specifically and reversibility to GSH with an ideal dissociation constant (K-d) of 2.59 mM and a fast response time (t(1/2) = 5.82 s). We also demonstrate that QG-1 detection of GSH is feasible in a model protein system. QG-1 was found to have extremely low cytotoxicity and was applied to determine the GSH concentration in live HeLa cells (5.40 +/- 0.87 mM). The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH‐related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed a ratiometric fluorescent probe (QG‐ 1 ) for quantitatively monitoring cellular GSH. The probe responds specifically and reversibility to GSH with an ideal dissociation constant ( K d ) of 2.59 m m and a fast response time ( t 1/2 =5.82 s). We also demonstrate that QG‐ 1 detection of GSH is feasible in a model protein system. QG‐ 1 was found to have extremely low cytotoxicity and was applied to determine the GSH concentration in live HeLa cells (5.40±0.87 m m ). The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH-related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed a ratiometric fluorescent probe (QG-1) for quantitatively monitoring cellular GSH. The probe responds specifically and reversibility to GSH with an ideal dissociation constant (Kd) of 2.59mm and a fast response time (t1/2=5.82s). We also demonstrate that QG-1 detection of GSH is feasible in a model protein system. QG-1 was found to have extremely low cytotoxicity and was applied to determine the GSH concentration in live HeLa cells (5.40±0.87mm). The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH‐related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed a ratiometric fluorescent probe (QG‐1) for quantitatively monitoring cellular GSH. The probe responds specifically and reversibility to GSH with an ideal dissociation constant (Kd) of 2.59 mm and a fast response time (t1/2=5.82 s). We also demonstrate that QG‐1 detection of GSH is feasible in a model protein system. QG‐1 was found to have extremely low cytotoxicity and was applied to determine the GSH concentration in live HeLa cells (5.40±0.87 mm). Given the green light: A ratiometric fluorescent probe (QG‐1) for monitoring and quantifying variations in cellular glutathione (GSH) was developed. The probe shows a fluorescence shift from red to green upon binding GSH and exhibits specificity and reversibility, with an appropriate dissociation constant for sensing species with high cellular abundance (Kd=2.59 mm) and a fast response time (t1/2=5.82 s). The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH-related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed a ratiometric fluorescent probe (QG-1) for quantitatively monitoring cellular GSH. The probe responds specifically and reversibility to GSH with an ideal dissociation constant (Kd ) of 2.59 mm and a fast response time (t1/2 =5.82 s). We also demonstrate that QG-1 detection of GSH is feasible in a model protein system. QG-1 was found to have extremely low cytotoxicity and was applied to determine the GSH concentration in live HeLa cells (5.40±0.87 mm).The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH-related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed a ratiometric fluorescent probe (QG-1) for quantitatively monitoring cellular GSH. The probe responds specifically and reversibility to GSH with an ideal dissociation constant (Kd ) of 2.59 mm and a fast response time (t1/2 =5.82 s). We also demonstrate that QG-1 detection of GSH is feasible in a model protein system. QG-1 was found to have extremely low cytotoxicity and was applied to determine the GSH concentration in live HeLa cells (5.40±0.87 mm). The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH-related pathological events. However, owing to their irreversible response mechanisms, most existing fluorescent GSH probes are not suitable for this purpose. We have developed a ratiometric fluorescent probe (QG-1) for quantitatively monitoring cellular GSH. The probe responds specifically and reversibility to GSH with an ideal dissociation constant (K ) of 2.59 mm and a fast response time (t =5.82 s). We also demonstrate that QG-1 detection of GSH is feasible in a model protein system. QG-1 was found to have extremely low cytotoxicity and was applied to determine the GSH concentration in live HeLa cells (5.40±0.87 mm). |
| Author | Yoon, Juyoung Miao, Yu Hu, Ying Wu, Xue Zhou, Xin Kwon, Nahyun Liu, Zhixue |
| Author_xml | – sequence: 1 givenname: Zhixue surname: Liu fullname: Liu, Zhixue organization: Yanbian University – sequence: 2 givenname: Xin surname: Zhou fullname: Zhou, Xin email: zhouxin@ybu.edu.cn organization: Yanbian University – sequence: 3 givenname: Yu surname: Miao fullname: Miao, Yu organization: Yanbian University – sequence: 4 givenname: Ying surname: Hu fullname: Hu, Ying organization: Ewha Womans University – sequence: 5 givenname: Nahyun surname: Kwon fullname: Kwon, Nahyun organization: Ewha Womans University – sequence: 6 givenname: Xue surname: Wu fullname: Wu, Xue email: wuxue@ybu.edu.cn organization: Yanbian University – sequence: 7 givenname: Juyoung surname: Yoon fullname: Yoon, Juyoung email: jyoon@ewha.ac.kr organization: Ewha Womans University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28371097$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim |
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| DBID | AAYXX CITATION 17B 1KM BLEPL DTL EGQ GYRTJ NPM 7TM K9. 7X8 |
| DOI | 10.1002/anie.201702114 |
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| Keywords | CELLS antioxidants ASSISTED ELECTROSTATIC ATTRACTION CYSTEINE SENSOR redox homeostasis fluorescent probes gluthionine MICHAEL ADDITION THIOLS IN-VIVO EMISSION CHANNELS ratiometric probes SELECTIVE DETECTION GSH |
| Language | English |
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| Snippet | The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH‐related pathological events.... The ability to monitor and quantify glutathione (GSH) in live cells is essential in order to gain a detailed understanding of GSH-related pathological events.... |
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| SubjectTerms | antioxidants Chemistry Chemistry, Multidisciplinary Cytotoxicity Fluorescence Fluorescent indicators fluorescent probes Glutathione gluthionine Monitoring Physical Sciences ratiometric probes redox homeostasis Response time Science & Technology Toxicity |
| Title | A Reversible Fluorescent Probe for Real‐Time Quantitative Monitoring of Cellular Glutathione |
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