Click Chemistry: Diverse Chemical Function from a Few Good Reactions

• Published in: Angewandte Chemie International Edition Vol. 40; no. 11; pp. 2004 - 2021
• Main Authors: Kolb, Hartmuth C., Finn, M. G., Sharpless, K. Barry
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag GmbH 01.06.2001; WILEY‐VCH Verlag GmbH
• Subjects: combinatorial chemistry; drug research; synthesis design; water chemistry

Examination of nature's favorite molecules reveals a striking preference for making carbon–heteroatom bonds over carbon–carbon bonds—surely no surprise given that carbon dioxide is nature's starting material and that most reactions are performed in water. Nucleic acids, proteins, and polys...