Construction of Various Bridged Polycyclic Skeletons by Palladium‐Catalyzed Dearomatization

• Published in: Angewandte Chemie International Edition Vol. 59; no. 21; pp. 8143 - 8147
• Main Authors: Mu, Xingye, Yu, Hanxiao, Peng, Henian, Xiong, Wenrui, Wu, Ting, Tang, Wenjun
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 18.05.2020; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: bridged tetracyclic systems; Catalysts; Chemistry; Chemistry, Multidisciplinary; dearomative cyclization; homogeneous catalysis; monophosphorus ligands; Natural products; Palladium; Physical Sciences; Science & Technology; ARYLATIVE DEAROMATIZATION; PRACTICAL SYNTHESIS; bridged tetracyclic systems; NATURAL-PRODUCTS; DINORDITERPENES; EFFICIENT ENANTIOSELECTIVE SYNTHESES; INDOLES; monophosphorus ligands; CHIRAL MONOPHOSPHORUS LIGANDS; homogeneous catalysis; STEREOCENTERS; palladium; SCLEROTIA; dearomative cyclization; CYCLIZATION

A powerful palladium‐catalyzed dearomative cyclization was developed that provides facile access to eight types of bridged tetracyclic skeletons bearing various ring sizes and heterocycles. With this method, several skeletons or analogues of natural products, including tubingensin B and dracaenones,...