Protein-protein interactions as a target for drugs in proteomics

• Published in: Proteomics (Weinheim) Vol. 3; no. 4; pp. 380 - 391
• Main Authors: Archakov, Alexander I., Govorun, Vadim M., Dubanov, Alexander V., Ivanov, Yuri D., Veselovsky, Alexander V., Lewi, Paul, Janssen, Paul
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.04.2003; WILEY‐VCH Verlag
• Subjects: Bioinformatics; Computational Biology - methods; Dimerizers; Drug Design; Inhibitor of protein dimerization; Protein Binding; Protein-protein interaction; Proteins - chemistry; Proteins - metabolism; Proteomics; Review; Target for drugs; Two-Hybrid System Techniques

Protein‐protein interactions play a central role in numerous processes in the cell and are one of the main fields of functional proteomics. This review highlights the methods of bioinformatics and functional proteomics of protein‐protein interaction investigation. The structures and properties of co...