One‐Step Synthesis of Acylboron Compounds via Copper‐Catalyzed Carbonylative Borylation of Alkyl Halides

• Published in: Angewandte Chemie International Edition Vol. 60; no. 4; pp. 2094 - 2098
• Main Authors: Cheng, Li‐Jie, Zhao, Siling, Mankad, Neal P.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 25.01.2021; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: acylboron; B2pin2; carbonylative borylation; Carbonyls; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Copper; Copper compounds; Functional groups; Halides; Intermediates; KATs; Physical Sciences; Potassium; Science & Technology; CONVENIENT SYNTHESIS; TRIALKYLBORANES; BORON; Bpin; carbonylative borylation; CARBON MONOXIDE; ORGANOBORANES; KATs; acylboron; ACYLTRIFLUOROBORATE; copper; ATMOSPHERIC PRESSURE; RADICALS; DIBORATION; CYCLIZATION; B2pin2

A copper‐catalyzed carbonylative borylation of unactivated alkyl halides has been developed, enabling efficient synthesis of aliphatic potassium acyltrifluoroborates (KATs) in high yields by treating the in situ formed tetracoordinated acylboron intermediates with aqueous KHF2. A variety of function...