Manganese activates autophagy to alleviate endoplasmic reticulum stress–induced apoptosis via PERK pathway

• Published in: Journal of cellular and molecular medicine Vol. 24; no. 1; pp. 328 - 341
• Main Authors: Liu, Chang, Yan, Dong‐Ying, Wang, Can, Ma, Zhuo, Deng, Yu, Liu, Wei, Xu, Bin
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2020; John Wiley and Sons Inc
• Subjects: Activating Transcription Factor 4 - metabolism; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy - drug effects; Cell Line, Tumor; Cytotoxicity; eIF-2 Kinase - metabolism; Endoplasmic reticulum; endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Enzymes; Flow cytometry; Gene expression; Gene Knockdown Techniques; Homeostasis; Humans; Kinases; Manganese; Manganese - pharmacology; Microtubule-Associated Proteins - genetics; Neurotoxicity; Original; PERK signalling pathway; Phagocytosis; Phenylbutyric acid; Promoter Regions, Genetic - genetics; Protein kinase; Proteins; Reagents; Ribonucleic acid; RNA; Signal transduction; Signal Transduction - drug effects; autophagy; neurotoxicity; manganese; PERK signalling pathway; endoplasmic reticulum stress

Overexposure to manganese (Mn) is neurotoxic. Our previous research has demonstrated that the interaction of endoplasmic reticulum (ER) stress and autophagy participates in the early stage of Mn‐mediated neurotoxicity in mouse. However, the mechanisms of ER stress signalling pathways in the initiati...