Human Adipose Stromal/Stem Cells from Obese Donors Show Reduced Efficacy in Halting Disease Progression in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

• Published in: Stem cells (Dayton, Ohio) Vol. 34; no. 3; pp. 614 - 626
• Main Authors: Strong, Amy L., Bowles, Annie C., Wise, Rachel M., Morand, Joseph P., Dutreil, Maria F., Gimble, Jeffrey M., Bunnell, Bruce A.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.03.2016
• Subjects: Adipocytes - metabolism; Adipocytes - transplantation; Adipose stromal/stem cells; Adipose Tissue - cytology; Adipose Tissue - metabolism; Adipose Tissue - transplantation; Adipose‐derived stromal/stem cells; Animals; Autoimmune diseases; Cell Differentiation - genetics; Central nervous system; Disease; Encephalomyelitis, Autoimmune, Experimental - pathology; Encephalomyelitis, Autoimmune, Experimental - therapy; Experimental autoimmune encephalomyelitis; Humans; Immunomodulatory properties; Inflammation - pathology; Inflammation - therapy; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Mice; Multiple sclerosis; Multiple Sclerosis - pathology; Multiple Sclerosis - therapy; Nervous system; Obesity; Obesity - genetics; Obesity - metabolism; Stem cells; Studies; Therapeutic efficacy; Tissue Donors; Obesity; Multiple sclerosis; Immunomodulatory properties; Experimental autoimmune encephalomyelitis; Therapeutic efficacy; Adipose stromal/stem cells; Adipose-derived stromal/stem cells

Multiple sclerosis is an autoimmune disease that affects the white matter of the central nervous system and involves inflammation and demyelination. The recent advances in our understanding of adipose‐derived stromal/stem cells (ASCs) and the utilization of these cells in clinical settings to treat...