Enantioselective Cascade Reaction for Synthesis of Quinolinones through Synergistic Catalysis Using Cu–Pybox and Chiral Benzotetramisole as Catalysts

• Published in: Chemistry : a European journal Vol. 23; no. 32; pp. 7689 - 7693
• Main Authors: Lu, Xuehe, Ge, Luo, Cheng, Cang, Chen, Jie, Cao, Weiguo, Wu, Xiaoyu
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 07.06.2017; Wiley Subscription Services, Inc
• Subjects: Acetic acid; Acids; Anhydrides; Aromatic compounds; Asymmetry; Bearing; Cascade chemical reactions; Catalysis; Catalysts; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Chlorides; copper; cyclization; Enantiomers; Lewis base; Physical Sciences; Protecting groups; quinolinones; Science & Technology; synergistic catalysis; synergistic catalysis; BICYCLIC BETA-LACTONES; ACTIVATION; ASYMMETRIC-SYNTHESIS; RECEPTOR ANTAGONISTS; METAL-CATALYSTS; cyclization; ACETIC-ACID ESTERS; quinolinones; CYCLOADDITION; PROPARGYLIC SUBSTITUTION; copper; Lewis base; DERIVATIVES; NCAL REACTIONS

In contrast to the well‐studied asymmetric catalyzed synthesis of tetrahydroquinolines, the asymmetric methodologies toward 3,4‐dihydroquinolin‐2‐ones are quite rare. Herein, the first asymmetric cascade reaction is reported between ethynyl benzoxazinanones and mixed‐anhydrides generated from aryl a...