Phthalocyanine‐Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy

• Published in: Angewandte Chemie International Edition Vol. 57; no. 31; pp. 9885 - 9890
• Main Authors: Li, Xingshu, Lee, Dayoung, Huang, Jian‐Dong, Yoon, Juyoung
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 26.07.2018
• Edition: International ed. in English
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Dismantling; Escherichia coli - drug effects; Escherichia coli - metabolism; Indoles - chemical synthesis; Indoles - chemistry; Indoles - pharmacology; Microbial Sensitivity Tests; Molecular chains; Molecular Structure; nanodots; Nanostructure; Nanostructures - chemistry; Optical properties; Particle Size; Photochemical Processes; Photochemotherapy; Photodynamic therapy; Photosensitizing Agents - chemical synthesis; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; phthalocyanine; Reactive oxygen species; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Staphylococcus aureus - drug effects; Staphylococcus aureus - metabolism; Surface Properties; type I photoreactions; nanodots; phthalocyanine; type I photoreactions; photodynamic therapy; reactive oxygen species

Owing to their unique, nanoscale related optical properties, nanostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics. However, most nanostructured PS assemblies are super‐quenched, thus, preventing their use in photodynamic therapy (PDT). Alt...