Analysis of changes in circular RNA expression and construction of ceRNA networks in human dilated cardiomyopathy

• Published in: Journal of cellular and molecular medicine Vol. 25; no. 5; pp. 2572 - 2583
• Main Authors: Lin, Zhenhao, Zhao, Yongchao, Dai, Fangjie, Su, Enyong, Li, Fuhai, Yan, Yan
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2021; John Wiley and Sons Inc
• Subjects: Binding sites; Cardiomyopathy; Cardiomyopathy, Dilated - diagnosis; Cardiomyopathy, Dilated - genetics; Cardiomyopathy, Dilated - physiopathology; Cardiovascular disease; Cardiovascular diseases; Chromosomes; Circular RNA; competitive endogenous RNA; Computational Biology - methods; Dilated cardiomyopathy; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Gene Regulatory Networks; Genomes; Heart; Humans; MicroRNAs; miRNA; mRNA; Original; Polymerase chain reaction; Reproducibility of Results; Reverse transcription; RNA Interference; RNA sequencing; RNA, Circular; RNA, Messenger; Software; RNA sequencing; mRNA; competitive endogenous RNA; circular RNA; dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a severe life‐threatening disease worldwide, and the underlying mechanisms remain unclear. Circular RNAs (circRNAs) have been reported to play important roles in various cardiovascular diseases and can function as competitive endogenous RNAs (ceRNAs). However, their r...