Effect of MU‐weighted multi‐leaf collimator position error on dose distribution of SBRT radiotherapy in peripheral non‐small cell lung cancer
Purpose Position accuracy of the multi‐leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the dosimetric impacts of the MU‐weighted MLC positioning uncertainties of SBRT for patients with early stage peripheral non‐small cell lung cancer (...
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Published in | Journal of applied clinical medical physics Vol. 21; no. 12; pp. 74 - 83 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
John Wiley & Sons, Inc
01.12.2020
John Wiley and Sons Inc |
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Abstract | Purpose
Position accuracy of the multi‐leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the dosimetric impacts of the MU‐weighted MLC positioning uncertainties of SBRT for patients with early stage peripheral non‐small cell lung cancer (NSCLC).
Methods
Three types of MLC position error were simulated: Type 1, random error; Type 2, system shift, in which both MLC banks shifted to the left or right direction; and Type 3, in which both MLC banks moved with same magnitudes in the opposite directions. Two baseline plans were generated: an automatic plan (AP) and a manually optimized plan (MP). Multi‐leaf collimator position errors were introduced to generate simulated plans with the preset MLC leaf position errors, which were then reimported into the Pinnacle system to generate simulated plans, respectively. The dosimetric parameters (CI, nCI, GI, etc.) and gEUD values of PTV and OARs were calculated. Linear regression between MU‐weighted/unweighted MLC position error and gEUD was performed to obtain dose sensitivity.
Results
The dose sensitivities of the PTVs were −4.93, −38.94, −41.70, −55.55, and 30.33 Gy/mm for random, left shift, right shift, system close, and system open MLC errors, respectively. There were significant differences between the MU‐weighted and the unweighted dose sensitivity, which was −38.94 Gy/mm vs −3.42 Gy/mm (left shift), −41.70 Gy/mm vs −3.56 Gy/mm (right shift), −55.55 Gy/mm vs −4.84 Gy/mm (system close), and 30.33 vs 2.64 Gy/mm (system open). For the system open/close MLC errors, as the PTV volume became larger, the dose sensitivity decreased. APs provided smaller dose sensitivity for the system shift and system close MLC errors compared to the conventional MPs.
Conclusions
There was significant difference in dose sensitivity between MU‐weighted and unweighted MLC position error of SBRT radiotherapy in peripheral NSCLC. MU is suggested to be included in the dosimetric evaluation of the MLC misalignments, since it is much closer to clinical radiotherapy. |
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AbstractList | Abstract
Purpose
Position accuracy of the multi‐leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the dosimetric impacts of the MU‐weighted MLC positioning uncertainties of SBRT for patients with early stage peripheral non‐small cell lung cancer (NSCLC).
Methods
Three types of MLC position error were simulated: Type 1, random error; Type 2, system shift, in which both MLC banks shifted to the left or right direction; and Type 3, in which both MLC banks moved with same magnitudes in the opposite directions. Two baseline plans were generated: an automatic plan (AP) and a manually optimized plan (MP). Multi‐leaf collimator position errors were introduced to generate simulated plans with the preset MLC leaf position errors, which were then reimported into the Pinnacle system to generate simulated plans, respectively. The dosimetric parameters (CI, nCI, GI, etc.) and gEUD values of PTV and OARs were calculated. Linear regression between MU‐weighted/unweighted MLC position error and gEUD was performed to obtain dose sensitivity.
Results
The dose sensitivities of the PTVs were −4.93, −38.94, −41.70, −55.55, and 30.33 Gy/mm for random, left shift, right shift, system close, and system open MLC errors, respectively. There were significant differences between the MU‐weighted and the unweighted dose sensitivity, which was −38.94 Gy/mm vs −3.42 Gy/mm (left shift), −41.70 Gy/mm vs −3.56 Gy/mm (right shift), −55.55 Gy/mm vs −4.84 Gy/mm (system close), and 30.33 vs 2.64 Gy/mm (system open). For the system open/close MLC errors, as the PTV volume became larger, the dose sensitivity decreased. APs provided smaller dose sensitivity for the system shift and system close MLC errors compared to the conventional MPs.
Conclusions
There was significant difference in dose sensitivity between MU‐weighted and unweighted MLC position error of SBRT radiotherapy in peripheral NSCLC. MU is suggested to be included in the dosimetric evaluation of the MLC misalignments, since it is much closer to clinical radiotherapy. PURPOSEPosition accuracy of the multi-leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the dosimetric impacts of the MU-weighted MLC positioning uncertainties of SBRT for patients with early stage peripheral non-small cell lung cancer (NSCLC). METHODSThree types of MLC position error were simulated: Type 1, random error; Type 2, system shift, in which both MLC banks shifted to the left or right direction; and Type 3, in which both MLC banks moved with same magnitudes in the opposite directions. Two baseline plans were generated: an automatic plan (AP) and a manually optimized plan (MP). Multi-leaf collimator position errors were introduced to generate simulated plans with the preset MLC leaf position errors, which were then reimported into the Pinnacle system to generate simulated plans, respectively. The dosimetric parameters (CI, nCI, GI, etc.) and gEUD values of PTV and OARs were calculated. Linear regression between MU-weighted/unweighted MLC position error and gEUD was performed to obtain dose sensitivity. RESULTSThe dose sensitivities of the PTVs were -4.93, -38.94, -41.70, -55.55, and 30.33 Gy/mm for random, left shift, right shift, system close, and system open MLC errors, respectively. There were significant differences between the MU-weighted and the unweighted dose sensitivity, which was -38.94 Gy/mm vs -3.42 Gy/mm (left shift), -41.70 Gy/mm vs -3.56 Gy/mm (right shift), -55.55 Gy/mm vs -4.84 Gy/mm (system close), and 30.33 vs 2.64 Gy/mm (system open). For the system open/close MLC errors, as the PTV volume became larger, the dose sensitivity decreased. APs provided smaller dose sensitivity for the system shift and system close MLC errors compared to the conventional MPs. CONCLUSIONSThere was significant difference in dose sensitivity between MU-weighted and unweighted MLC position error of SBRT radiotherapy in peripheral NSCLC. MU is suggested to be included in the dosimetric evaluation of the MLC misalignments, since it is much closer to clinical radiotherapy. Position accuracy of the multi-leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the dosimetric impacts of the MU-weighted MLC positioning uncertainties of SBRT for patients with early stage peripheral non-small cell lung cancer (NSCLC). Three types of MLC position error were simulated: Type 1, random error; Type 2, system shift, in which both MLC banks shifted to the left or right direction; and Type 3, in which both MLC banks moved with same magnitudes in the opposite directions. Two baseline plans were generated: an automatic plan (AP) and a manually optimized plan (MP). Multi-leaf collimator position errors were introduced to generate simulated plans with the preset MLC leaf position errors, which were then reimported into the Pinnacle system to generate simulated plans, respectively. The dosimetric parameters (CI, nCI, GI, etc.) and gEUD values of PTV and OARs were calculated. Linear regression between MU-weighted/unweighted MLC position error and gEUD was performed to obtain dose sensitivity. The dose sensitivities of the PTVs were -4.93, -38.94, -41.70, -55.55, and 30.33 Gy/mm for random, left shift, right shift, system close, and system open MLC errors, respectively. There were significant differences between the MU-weighted and the unweighted dose sensitivity, which was -38.94 Gy/mm vs -3.42 Gy/mm (left shift), -41.70 Gy/mm vs -3.56 Gy/mm (right shift), -55.55 Gy/mm vs -4.84 Gy/mm (system close), and 30.33 vs 2.64 Gy/mm (system open). For the system open/close MLC errors, as the PTV volume became larger, the dose sensitivity decreased. APs provided smaller dose sensitivity for the system shift and system close MLC errors compared to the conventional MPs. There was significant difference in dose sensitivity between MU-weighted and unweighted MLC position error of SBRT radiotherapy in peripheral NSCLC. MU is suggested to be included in the dosimetric evaluation of the MLC misalignments, since it is much closer to clinical radiotherapy. PurposePosition accuracy of the multi‐leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the dosimetric impacts of the MU‐weighted MLC positioning uncertainties of SBRT for patients with early stage peripheral non‐small cell lung cancer (NSCLC).MethodsThree types of MLC position error were simulated: Type 1, random error; Type 2, system shift, in which both MLC banks shifted to the left or right direction; and Type 3, in which both MLC banks moved with same magnitudes in the opposite directions. Two baseline plans were generated: an automatic plan (AP) and a manually optimized plan (MP). Multi‐leaf collimator position errors were introduced to generate simulated plans with the preset MLC leaf position errors, which were then reimported into the Pinnacle system to generate simulated plans, respectively. The dosimetric parameters (CI, nCI, GI, etc.) and gEUD values of PTV and OARs were calculated. Linear regression between MU‐weighted/unweighted MLC position error and gEUD was performed to obtain dose sensitivity.ResultsThe dose sensitivities of the PTVs were −4.93, −38.94, −41.70, −55.55, and 30.33 Gy/mm for random, left shift, right shift, system close, and system open MLC errors, respectively. There were significant differences between the MU‐weighted and the unweighted dose sensitivity, which was −38.94 Gy/mm vs −3.42 Gy/mm (left shift), −41.70 Gy/mm vs −3.56 Gy/mm (right shift), −55.55 Gy/mm vs −4.84 Gy/mm (system close), and 30.33 vs 2.64 Gy/mm (system open). For the system open/close MLC errors, as the PTV volume became larger, the dose sensitivity decreased. APs provided smaller dose sensitivity for the system shift and system close MLC errors compared to the conventional MPs.ConclusionsThere was significant difference in dose sensitivity between MU‐weighted and unweighted MLC position error of SBRT radiotherapy in peripheral NSCLC. MU is suggested to be included in the dosimetric evaluation of the MLC misalignments, since it is much closer to clinical radiotherapy. Purpose Position accuracy of the multi‐leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the dosimetric impacts of the MU‐weighted MLC positioning uncertainties of SBRT for patients with early stage peripheral non‐small cell lung cancer (NSCLC). Methods Three types of MLC position error were simulated: Type 1, random error; Type 2, system shift, in which both MLC banks shifted to the left or right direction; and Type 3, in which both MLC banks moved with same magnitudes in the opposite directions. Two baseline plans were generated: an automatic plan (AP) and a manually optimized plan (MP). Multi‐leaf collimator position errors were introduced to generate simulated plans with the preset MLC leaf position errors, which were then reimported into the Pinnacle system to generate simulated plans, respectively. The dosimetric parameters (CI, nCI, GI, etc.) and gEUD values of PTV and OARs were calculated. Linear regression between MU‐weighted/unweighted MLC position error and gEUD was performed to obtain dose sensitivity. Results The dose sensitivities of the PTVs were −4.93, −38.94, −41.70, −55.55, and 30.33 Gy/mm for random, left shift, right shift, system close, and system open MLC errors, respectively. There were significant differences between the MU‐weighted and the unweighted dose sensitivity, which was −38.94 Gy/mm vs −3.42 Gy/mm (left shift), −41.70 Gy/mm vs −3.56 Gy/mm (right shift), −55.55 Gy/mm vs −4.84 Gy/mm (system close), and 30.33 vs 2.64 Gy/mm (system open). For the system open/close MLC errors, as the PTV volume became larger, the dose sensitivity decreased. APs provided smaller dose sensitivity for the system shift and system close MLC errors compared to the conventional MPs. Conclusions There was significant difference in dose sensitivity between MU‐weighted and unweighted MLC position error of SBRT radiotherapy in peripheral NSCLC. MU is suggested to be included in the dosimetric evaluation of the MLC misalignments, since it is much closer to clinical radiotherapy. |
Author | Shao, Yan Duan, YanHua Ying, YanChen Yue, Ning Jeff Xu, ZhiYong Chen, Hua Feng, AiHui Gu, HengLe Wang, Hao |
AuthorAffiliation | 2 Shcool of Physics and Technology University of Wuhan Wuhan China 3 Department of Radiation Oncology Rutgers Cancer Institute of New Jersey Rutgers University New Brunswick NJ USA 1 Department of Radiation Oncology Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China |
AuthorAffiliation_xml | – name: 2 Shcool of Physics and Technology University of Wuhan Wuhan China – name: 3 Department of Radiation Oncology Rutgers Cancer Institute of New Jersey Rutgers University New Brunswick NJ USA – name: 1 Department of Radiation Oncology Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China |
Author_xml | – sequence: 1 givenname: AiHui surname: Feng fullname: Feng, AiHui organization: Shanghai Jiao Tong University – sequence: 2 givenname: Hua surname: Chen fullname: Chen, Hua organization: Shanghai Jiao Tong University – sequence: 3 givenname: Hao surname: Wang fullname: Wang, Hao organization: Shanghai Jiao Tong University – sequence: 4 givenname: HengLe surname: Gu fullname: Gu, HengLe organization: Shanghai Jiao Tong University – sequence: 5 givenname: Yan surname: Shao fullname: Shao, Yan organization: Shanghai Jiao Tong University – sequence: 6 givenname: YanHua surname: Duan fullname: Duan, YanHua organization: Shanghai Jiao Tong University – sequence: 7 givenname: YanChen surname: Ying fullname: Ying, YanChen organization: University of Wuhan – sequence: 8 givenname: Ning Jeff surname: Yue fullname: Yue, Ning Jeff organization: Rutgers University – sequence: 9 givenname: ZhiYong surname: Xu fullname: Xu, ZhiYong email: xzyong12vip@sina.com organization: Shanghai Jiao Tong University |
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CitedBy_id | crossref_primary_10_1371_journal_pone_0278422 crossref_primary_10_1002_acm2_13212 crossref_primary_10_1002_acm2_14158 crossref_primary_10_1080_09553002_2023_2261549 |
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Copyright | 2020 The Authors. published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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Position accuracy of the multi‐leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the... Position accuracy of the multi-leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the dosimetric... Abstract Purpose Position accuracy of the multi‐leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate... PurposePosition accuracy of the multi‐leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the... PURPOSEPosition accuracy of the multi-leaf collimator (MLC) is essential in stereotactic body radiotherapy (SBRT). This study is aimed to investigate the... |
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SubjectTerms | Algorithms auto‐planning Cancer therapies Conformity Dosimetry Lung cancer MLC position error MU‐weighted Optimization Patients Radiation Oncology Physics Radiation therapy SBRT Simulation |
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Title | Effect of MU‐weighted multi‐leaf collimator position error on dose distribution of SBRT radiotherapy in peripheral non‐small cell lung cancer |
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