Expression of interferon‐stimulated gene 15‐kDa protein, cyclooxygenase (COX) 1, COX‐2, aldo‐keto reductase family 1, member B1, and prostaglandin E synthase in the spleen during early pregnancy in sheep

• Published in: Animal science journal Vol. 89; no. 11; pp. 1540 - 1548
• Main Authors: Yang, Ling, Liu, Yong, Lv, Wan, Wang, Pengda, Wang, Bin, Xue, Jie, Zhang, Leying
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.11.2018
• Subjects: Aldehyde Reductase - genetics; Aldehyde Reductase - metabolism; Animals; autocrine signaling; Autocrine signalling; conjugated proteins; Cords; Cyclooxygenase 1 - genetics; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - genetics; Cyclooxygenase 2 - metabolism; Cyclooxygenase-1; Cytokines - genetics; Cytokines - metabolism; Dimers; estrous cycle; Estrus cycle; ewes; Female; Gene Expression; gene expression regulation; genes; Immune response; Immune system; Immunohistochemistry; Immunoregulation; Interferon; ISG15; messenger RNA; mRNA; Paracrine signalling; Placentation - genetics; Placentation - physiology; Pregnancy; Pregnancy, Animal - genetics; Pregnancy, Animal - immunology; Prostaglandin E; prostaglandin synthase; Prostaglandin-E Synthases - genetics; Prostaglandin-E Synthases - metabolism; prostaglandin-F synthase; Prostaglandins; Proteins; quantitative polymerase chain reaction; Reductase; Sheep; Sheep - genetics; Sheep - metabolism; Spleen; Spleen - immunology; Spleen - metabolism; Ubiquitins - genetics; Ubiquitins - metabolism; Up-Regulation; Uterus; Uterus - metabolism; Western blotting; prostaglandin synthase; ISG15; spleen; sheep; pregnancy

The spleen is a unique lymphoid organ that plays a key role in immune regulation. Interferon‐tau induces upregulation of interferon‐stimulated gene 15‐kDa protein (ISG15) in the uterus during early pregnancy in sheep. Prostaglandins (PGs) have important effects in both the activation and the inhibit...