Direct Photocatalytic Synthesis of Medium‐Sized Lactams by C−C Bond Cleavage

• Published in: Angewandte Chemie International Edition Vol. 57; no. 43; pp. 14225 - 14229
• Main Authors: Wang, Na, Gu, Qiang‐Shuai, Li, Zhong‐Liang, Li, Zhuang, Guo, Yu‐Long, Guo, Zhen, Liu, Xin‐Yuan
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 22.10.2018; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Aromatic compounds; Chemistry; Chemistry, Multidisciplinary; heterocycles; Ketones; medium-sized rings; Migration; photochemistry; Physical Sciences; radicals; Science & Technology; Substrates; Synthesis; CATALYSIS; medium-sized rings; radicals; RING-EXPANSION; MACROCYCLES; VISIBLE-LIGHT PHOTOREDOX; EFFICIENT SYNTHESIS; ketones; FUNCTIONALIZATION; REARRANGEMENT; heterocycles; photochemistry; CONSTRUCTION; CYCLIZATION

Reported is a novel two‐step ring‐expansion strategy for expeditious synthesis of all ring sizes of synthetically challenging (hetero)aryl‐fused medium‐sized lactams from readily available 5–8‐membered cyclic ketones. This step‐economic approach features a remote radical (hetero)aryl migration from...