Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats

• Published in: Journal of cellular and molecular medicine Vol. 23; no. 4; pp. 2822 - 2835
• Main Authors: Ma, Yongbin, Dong, Liyang, Zhou, Dan, Li, Li, Zhang, Wenzhe, Zhen, Yu, Wang, Ting, Su, Jianhua, Chen, Deyu, Mao, Chaoming, Wang, Xuefeng
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2019; John Wiley and Sons Inc
• Subjects: Animals; Antibodies; Atrophy; Axons; Cells, Cultured; Cytokines; Extracellular vesicles; Extracellular Vesicles - transplantation; Gastrocnemius muscle; human umbilical cord mesenchymal stem cell; Humans; improve; Male; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchyme; Morphology; Muscle, Skeletal - injuries; Muscular Atrophy - etiology; Muscular Atrophy - pathology; Muscular Atrophy - therapy; Nerve Regeneration; Original; Peripheral Nerve Injuries - etiology; Peripheral Nerve Injuries - pathology; Peripheral Nerve Injuries - therapy; Peripheral nerves; Proteins; Rats; Rats, Sprague-Dawley; Recovery of Function; Regeneration; Schwann cells; Sciatic nerve; Sciatic Nerve - injuries; Sciatic Nerve - surgery; sciatic nerve transection; Silicones; Stem cell transplantation; Stem cells; Surgery; Umbilical cord; Umbilical Cord - cytology; United States > US; China; Japan; nerve regeneration; extracellular vesicles; human umbilical cord mesenchymal stem cell; improve; sciatic nerve transection

Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration. The involvement of human umbilical cord MSC‐derived extracellular vesicles (hUCMSC‐EVs) in peripheral nerve regenerat...