Catalytic Biomimetic Asymmetric Reduction of Alkenes and Imines Enabled by Chiral and Regenerable NAD(P)H Models

• Published in: Angewandte Chemie International Edition Vol. 58; no. 6; pp. 1813 - 1817
• Main Authors: Wang, Jie, Zhu, Zhou‐Hao, Chen, Mu‐Wang, Chen, Qing‐An, Zhou, Yong‐Gui
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 04.02.2019; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alkenes; asymmetric synthesis; Asymmetry; biomimetic chemistry; Biomimetics; Catalysis; Catalysts; Chemistry; Chemistry, Multidisciplinary; Imines; NAD; Organic chemistry; Physical Sciences; Reduction; Science & Technology; synthetic methods; QUINOLINES; alkenes; HANTZSCH ESTERS; HYDROAMINATION/ASYMMETRIC TRANSFER HYDROGENATION; ENANTIOSELECTIVE TRANSFER HYDROGENATION; DEHYDROGENASE; asymmetric synthesis; NADH; BENZOTHIAZOLINE; biomimetic chemistry; reduction; ORGANOCATALYTIC TRANSFER HYDROGENATION; DERIVATIVES; synthetic methods; METAL-FREE

The development of biomimetic chemistry based on the NAD(P)H with hydrogen gas as terminal reductant is a long‐standing challenge. Through rational design of the chiral and regenerable NAD(P)H analogues based on planar‐chiral ferrocene, a biomimetic asymmetric reduction has been realized using bench...