Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins
eIF4E-binding proteins (4E-BPs) regulate translation of mRNAs in eukaryotes. However the extent to which specific mRNA targets are regulated by 4E-BPs remains unknown. We performed translational profiling by microarray analysis of polysome and monosome associated mRNAs in wild-type and mutant cells...
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Published in | Nucleic acids research Vol. 38; no. 22; pp. 8039 - 8050 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Oxford University Press
01.12.2010
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Abstract | eIF4E-binding proteins (4E-BPs) regulate translation of mRNAs in eukaryotes. However the extent to which specific mRNA targets are regulated by 4E-BPs remains unknown. We performed translational profiling by microarray analysis of polysome and monosome associated mRNAs in wild-type and mutant cells to identify mRNAs in yeast regulated by the 4E-BPs Caf20p and Eap1p; the first-global comparison of 4E-BP target mRNAs. We find that yeast 4E-BPs modulate the translation of >1000 genes. Most target mRNAs differ between the 4E-BPs revealing mRNA specificity for translational control by each 4E-BP. This is supported by observations that eap1Δ and caf20Δ cells have different nitrogen source utilization defects, implying different mRNA targets. To account for the mRNA specificity shown by each 4E-BP, we found correlations between our data sets and previously determined targets of yeast mRNA-binding proteins. We used affinity chromatography experiments to uncover specific RNA-stabilized complexes formed between Caf20p and Puf4p/Puf5p and between Eap1p and Puf1p/Puf2p. Thus the combined action of each 4E-BP with specific 3'-UTR-binding proteins mediates mRNA-specific translational control in yeast, showing that this form of translational control is more widely employed than previously thought. |
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AbstractList | eIF4E-binding proteins (4E-BPs) regulate translation of mRNAs in eukaryotes. However the extent to which specific mRNA targets are regulated by 4E-BPs remains unknown. We performed translational profiling by microarray analysis of polysome and monosome associated mRNAs in wild-type and mutant cells to identify mRNAs in yeast regulated by the 4E-BPs Caf20p and Eap1p; the first-global comparison of 4E-BP target mRNAs. We find that yeast 4E-BPs modulate the translation of >1000 genes. Most target mRNAs differ between the 4E-BPs revealing mRNA specificity for translational control by each 4E-BP. This is supported by observations that
eap1
Δ and
caf20
Δ cells have different nitrogen source utilization defects, implying different mRNA targets. To account for the mRNA specificity shown by each 4E-BP, we found correlations between our data sets and previously determined targets of yeast mRNA-binding proteins. We used affinity chromatography experiments to uncover specific RNA-stabilized complexes formed between Caf20p and Puf4p/Puf5p and between Eap1p and Puf1p/Puf2p. Thus the combined action of each 4E-BP with specific 3′-UTR-binding proteins mediates mRNA-specific translational control in yeast, showing that this form of translational control is more widely employed than previously thought. eIF4E-binding proteins (4E-BPs) regulate translation of mRNAs in eukaryotes. However the extent to which specific mRNA targets are regulated by 4E-BPs remains unknown. We performed translational profiling by microarray analysis of polysome and monosome associated mRNAs in wild-type and mutant cells to identify mRNAs in yeast regulated by the 4E-BPs Caf20p and Eap1p; the first-global comparison of 4E-BP target mRNAs. We find that yeast 4E-BPs modulate the translation of >1000 genes. Most target mRNAs differ between the 4E-BPs revealing mRNA specificity for translational control by each 4E-BP. This is supported by observations that eap1 Delta and caf20 Delta cells have different nitrogen source utilization defects, implying different mRNA targets. To account for the mRNA specificity shown by each 4E-BP, we found correlations between our data sets and previously determined targets of yeast mRNA-binding proteins. We used affinity chromatography experiments to uncover specific RNA-stabilized complexes formed between Caf20p and Puf4p/Puf5p and between Eap1p and Puf1p/Puf2p. Thus the combined action of each 4E-BP with specific 3'-UTR-binding proteins mediates mRNA-specific translational control in yeast, showing that this form of translational control is more widely employed than previously thought. eIF4E-binding proteins (4E-BPs) regulate translation of mRNAs in eukaryotes. However the extent to which specific mRNA targets are regulated by 4E-BPs remains unknown. We performed translational profiling by microarray analysis of polysome and monosome associated mRNAs in wild-type and mutant cells to identify mRNAs in yeast regulated by the 4E-BPs Caf20p and Eap1p; the first-global comparison of 4E-BP target mRNAs. We find that yeast 4E-BPs modulate the translation of >1000 genes. Most target mRNAs differ between the 4E-BPs revealing mRNA specificity for translational control by each 4E-BP. This is supported by observations that eap1Δ and caf20Δ cells have different nitrogen source utilization defects, implying different mRNA targets. To account for the mRNA specificity shown by each 4E-BP, we found correlations between our data sets and previously determined targets of yeast mRNA-binding proteins. We used affinity chromatography experiments to uncover specific RNA-stabilized complexes formed between Caf20p and Puf4p/Puf5p and between Eap1p and Puf1p/Puf2p. Thus the combined action of each 4E-BP with specific 3'-UTR-binding proteins mediates mRNA-specific translational control in yeast, showing that this form of translational control is more widely employed than previously thought. |
Author | Castelli, Lydia M McCarthy, John E G Hubbard, Simon J Grant, Christopher M Ashe, Mark P Smirnova, Julia B Rowe, William Selley, Julian N Cridge, Andrew G Pavitt, Graham D |
AuthorAffiliation | 1 The Michael Smith Building and 2 Manchester Interdisciplinary Biocentre, Faculty of Life Sciences, University of Manchester, Manchester, UK |
AuthorAffiliation_xml | – name: 1 The Michael Smith Building and 2 Manchester Interdisciplinary Biocentre, Faculty of Life Sciences, University of Manchester, Manchester, UK |
Author_xml | – sequence: 1 givenname: Andrew G surname: Cridge fullname: Cridge, Andrew G organization: The Michael Smith Building, Faculty of Life Sciences, University of Manchester, Manchester, UK – sequence: 2 givenname: Lydia M surname: Castelli fullname: Castelli, Lydia M – sequence: 3 givenname: Julia B surname: Smirnova fullname: Smirnova, Julia B – sequence: 4 givenname: Julian N surname: Selley fullname: Selley, Julian N – sequence: 5 givenname: William surname: Rowe fullname: Rowe, William – sequence: 6 givenname: Simon J surname: Hubbard fullname: Hubbard, Simon J – sequence: 7 givenname: John E G surname: McCarthy fullname: McCarthy, John E G – sequence: 8 givenname: Mark P surname: Ashe fullname: Ashe, Mark P – sequence: 9 givenname: Christopher M surname: Grant fullname: Grant, Christopher M – sequence: 10 givenname: Graham D surname: Pavitt fullname: Pavitt, Graham D |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20705650$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1101/gad.1611308 10.1128/MCB.00495-07 10.1038/nrm2838 10.1074/jbc.M601545200 10.1261/rna.7270204 10.1002/yea.931 10.1073/pnas.0307425100 10.1371/journal.pbio.0020079 10.1128/MCB.25.13.5499-5513.2005 10.1261/rna.847408 10.1016/S1097-2765(04)00008-5 10.1007/s002940050324 10.1093/emboj/16.5.1114 10.1091/mbc.E07-11-1173 10.1016/S0092-8674(01)00318-X 10.1093/genetics/122.1.19 10.1083/jcb.200507138 10.1101/gad.1119403 10.1261/rna.2168505 10.1093/genetics/144.3.967 10.1093/genetics/158.1.187 10.1101/gad.912401 10.1016/S1534-5807(03)00400-3 10.1523/JNEUROSCI.2282-04.2004 10.1128/MCB.20.10.3558-3567.2000 10.1016/S0168-9525(01)02616-6 10.1101/gad.1189004 10.1101/gad.524209 10.1093/emboj/20.16.4423 10.1371/journal.pbio.0060255 10.1101/gad.11.19.2522 10.1128/MCB.24.8.3089-3099.2004 10.1073/pnas.2033246100 10.1128/MCB.20.13.4604-4613.2000 10.1074/jbc.M611253200 10.1091/mbc.E05-11-1039 10.1002/yea.1142 10.1016/j.molcel.2007.05.016 10.1002/yea.1415 10.1128/EC.00121-06 10.1038/nature03205 10.1073/pnas.94.10.5201 10.1042/bj3400135 10.1128/MCB.25.21.9340-9349.2005 10.1261/rna.2070110 10.1038/nsb1015 10.1128/MCB.13.10.6102 |
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Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Present address: Andrew G. Cridge, Massey University, Institute of Natural Sciences, Albany, New Zealand. The authors wish it to be known that, in their opinion, the first three authors should be regarded as joint First Authors. |
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References | 11858839 - Trends Genet. 2002 Mar;18(3):150-7 19571182 - Genes Dev. 2009 Jul 1;23(13):1559-70 14723848 - Dev Cell. 2004 Jan;6(1):69-78 9334317 - Genes Dev. 1997 Oct 1;11(19):2522-31 15198983 - Genes Dev. 2004 Jun 15;18(12):1452-65 15337848 - RNA. 2004 Oct;10(10):1625-36 14704279 - Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):434-9 8413212 - Mol Cell Biol. 1993 Oct;13(10):6102-13 15964806 - Mol Cell Biol. 2005 Jul;25(13):5499-513 13679573 - Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11429-34 20427513 - RNA. 2010 Jun;16(6):1217-25 14608375 - Nat Struct Biol. 2003 Dec;10(12):1039-47 15334558 - Yeast. 2004 Aug;21(11):947-62 17526738 - Mol Cell Biol. 2007 Jul;27(14):5225-34 2659436 - Genetics. 1989 May;122(1):19-27 18094119 - RNA. 2008 Feb;14(2):246-62 14561773 - Genes Dev. 2003 Oct 15;17(20):2508-13 14967143 - Mol Cell. 2004 Feb 13;13(3):357-66 8913742 - Genetics. 1996 Nov;144(3):967-78 15470135 - J Neurosci. 2004 Oct 6;24(40):8695-703 10779345 - Mol Cell Biol. 2000 May;20(10):3558-67 11691836 - Genes Dev. 2001 Nov 1;15(21):2852-64 15690031 - Nature. 2005 Feb 3;433(7025):477-80 16401725 - J Cell Biol. 2006 Jan 16;172(2):295-307 16381812 - Mol Biol Cell. 2006 Mar;17(3):1164-75 17083129 - Yeast. 2006 Oct-Nov;23(14-15):1075-88 12489126 - Yeast. 2003 Jan 15;20(1):53-67 18959479 - PLoS Biol. 2008 Oct 28;6(10):e255 15060133 - Mol Cell Biol. 2004 Apr;24(8):3089-99 9118949 - EMBO J. 1997 Mar 3;16(5):1114-21 17389596 - J Biol Chem. 2007 May 25;282(21):15430-8 11336677 - Cell. 2001 Apr 20;105(2):281-9 16227585 - Mol Cell Biol. 2005 Nov;25(21):9340-9 11333229 - Genetics. 2001 May;158(1):187-96 18417611 - Mol Biol Cell. 2008 Jul;19(7):2995-3007 17041186 - Eukaryot Cell. 2006 Dec;5(12):2120-7 15024427 - PLoS Biol. 2004 Mar;2(3):E79 10229668 - Biochem J. 1999 May 15;340 ( Pt 1):135-41 17588515 - Mol Cell. 2007 Jun 22;26(6):795-809 16244132 - RNA. 2005 Nov;11(11):1655-66 10848587 - Mol Cell Biol. 2000 Jul;20(13):4604-13 9144215 - Proc Natl Acad Sci U S A. 1997 May 13;94(10):5201-6 16849329 - J Biol Chem. 2006 Sep 29;281(39):29011-21 18413716 - Genes Dev. 2008 Apr 15;22(8):1037-50 9508791 - Curr Genet. 1998 Mar;33(3):171-7 20094052 - Nat Rev Mol Cell Biol. 2010 Feb;11(2):113-27 11500370 - EMBO J. 2001 Aug 15;20(16):4423-31 Smirnova ( key 20170720163656_B21) 2005; 25 Van Komen ( key 20170720163656_B27) 2006; 172 Adams ( key 20170720163656_B17) 1998 Inada ( key 20170720163656_B38) 2004; 101 Shepard ( key 20170720163656_B31) 2003; 100 Richter ( key 20170720163656_B2) 2005; 433 Takahata ( key 20170720163656_B26) 2004; 24 Edwards ( key 20170720163656_B42) 2001; 105 Anderson ( key 20170720163656_B28) 1993; 13 Warringer ( key 20170720163656_B18) 2003; 20 Pannone ( key 20170720163656_B25) 2001; 158 Thompson ( key 20170720163656_B5) 2007 Deloche ( key 20170720163656_B12) 2004; 13 Gingras ( key 20170720163656_B4) 2001; 15 Hogan ( key 20170720163656_B39) 2008; 6 Polymenis ( key 20170720163656_B13) 1997; 11 Nakamura ( key 20170720163656_B30) 2004; 6 Jackson ( key 20170720163656_B1) 2010; 11 Jackson ( key 20170720163656_B45) 2004; 10 Janke ( key 20170720163656_B20) 2004; 21 Meier ( key 20170720163656_B11) 2006; 17 Liu ( key 20170720163656_B35) 1996; 144 Ibrahimo ( key 20170720163656_B10) 2006; 23 Sezen ( key 20170720163656_B15) 2009; 23 Ulbricht ( key 20170720163656_B47) 2008; 14 Mohammad-Qureshi ( key 20170720163656_B23) 2007; 27 Wickens ( key 20170720163656_B40) 2002; 18 Edwards ( key 20170720163656_B43) 2003; 17 Hook ( key 20170720163656_B48) 2007; 282 Deng ( key 20170720163656_B33) 2008; 22 Chritton ( key 20170720163656_B49) 2010; 16 Preiss ( key 20170720163656_B29) 2003; 10 de la Cruz ( key 20170720163656_B8) 1997; 94 Sikorski ( key 20170720163656_B16) 1989; 122 Jager ( key 20170720163656_B24) 2001; 20 Danaie ( key 20170720163656_B14) 1999; 340 Shenton ( key 20170720163656_B22) 2006; 281 Duttagupta ( key 20170720163656_B37) 2005; 25 Paquin ( key 20170720163656_B32) 2007; 26 Cosentino ( key 20170720163656_B7) 2000; 20 Regenberg ( key 20170720163656_B36) 1998; 33 Mascarenhas ( key 20170720163656_B9) 2008; 19 Altmann ( key 20170720163656_B6) 1997; 16 Gu ( key 20170720163656_B44) 2004; 18 Park ( key 20170720163656_B34) 2006; 5 Mee ( key 20170720163656_B41) 2004; 24 Houshmandi ( key 20170720163656_B46) 2005; 11 Mothe-Satney ( key 20170720163656_B3) 2000; 20 Gerber ( key 20170720163656_B19) 2004; 2 |
References_xml | – volume: 22 start-page: 1037 year: 2008 ident: key 20170720163656_B33 article-title: Translation of ASH1 mRNA is repressed by Puf6p-Fun12p/eIF5B interaction and released by CK2 phosphorylation publication-title: Genes Dev. doi: 10.1101/gad.1611308 contributor: fullname: Deng – volume: 27 start-page: 5225 year: 2007 ident: key 20170720163656_B23 article-title: Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00495-07 contributor: fullname: Mohammad-Qureshi – volume: 11 start-page: 113 year: 2010 ident: key 20170720163656_B1 article-title: The mechanism of eukaryotic translation initiation and principles of its regulation publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2838 contributor: fullname: Jackson – volume: 281 start-page: 29011 year: 2006 ident: key 20170720163656_B22 article-title: Global translational responses to oxidative stress impact upon multiple levels of protein synthesis publication-title: J. Biol. Chem. doi: 10.1074/jbc.M601545200 contributor: fullname: Shenton – volume: 10 start-page: 1625 year: 2004 ident: key 20170720163656_B45 article-title: Recruitment of the Puf3 protein to its mRNA target for regulation of mRNA decay in yeast publication-title: RNA doi: 10.1261/rna.7270204 contributor: fullname: Jackson – volume: 20 start-page: 53 year: 2003 ident: key 20170720163656_B18 article-title: Automated screening in environmental arrays allows analysis of quantitative phenotypic profiles in Saccharomyces cerevisiae publication-title: Yeast doi: 10.1002/yea.931 contributor: fullname: Warringer – volume: 101 start-page: 434 year: 2004 ident: key 20170720163656_B38 article-title: Identification of Lhp1p-associated RNAs by microarray analysis in Saccharomyces cerevisiae reveals association with coding and noncoding RNAs publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0307425100 contributor: fullname: Inada – volume: 2 start-page: E79 year: 2004 ident: key 20170720163656_B19 article-title: Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0020079 contributor: fullname: Gerber – volume: 25 start-page: 5499 year: 2005 ident: key 20170720163656_B37 article-title: Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.25.13.5499-5513.2005 contributor: fullname: Duttagupta – volume: 14 start-page: 246 year: 2008 ident: key 20170720163656_B47 article-title: Puf1p acts in combination with other yeast Puf proteins to control mRNA stability publication-title: RNA doi: 10.1261/rna.847408 contributor: fullname: Ulbricht – volume: 13 start-page: 357 year: 2004 ident: key 20170720163656_B12 article-title: A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae publication-title: Mol. Cell doi: 10.1016/S1097-2765(04)00008-5 contributor: fullname: Deloche – volume-title: Methods in Yeast genetics: A Cold Spring Harbor Laboratory Course Manual year: 1998 ident: key 20170720163656_B17 contributor: fullname: Adams – volume: 33 start-page: 171 year: 1998 ident: key 20170720163656_B36 article-title: Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces cerevisiae publication-title: Curr. Genet. doi: 10.1007/s002940050324 contributor: fullname: Regenberg – volume: 16 start-page: 1114 year: 1997 ident: key 20170720163656_B6 article-title: A novel inhibitor of cap-dependent translation initiation in yeast: p20 competes with eIF4G for binding to eIF4E publication-title: EMBO J. doi: 10.1093/emboj/16.5.1114 contributor: fullname: Altmann – volume: 19 start-page: 2995 year: 2008 ident: key 20170720163656_B9 article-title: Gcn4 Is Required for the Response to Peroxide Stress in the Yeast Saccharomyces cerevisiae publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E07-11-1173 contributor: fullname: Mascarenhas – volume: 105 start-page: 281 year: 2001 ident: key 20170720163656_B42 article-title: Structure of Pumilio reveals similarity between RNA and peptide binding motifs publication-title: Cell doi: 10.1016/S0092-8674(01)00318-X contributor: fullname: Edwards – volume: 122 start-page: 19 year: 1989 ident: key 20170720163656_B16 article-title: A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae publication-title: Genetics doi: 10.1093/genetics/122.1.19 contributor: fullname: Sikorski – volume: 172 start-page: 295 year: 2006 ident: key 20170720163656_B27 article-title: An intramolecular t-SNARE complex functions in vivo without the syntaxin NH2-terminal regulatory domain publication-title: J. Cell Biol. doi: 10.1083/jcb.200507138 contributor: fullname: Van Komen – volume: 17 start-page: 2508 year: 2003 ident: key 20170720163656_B43 article-title: Model of the brain tumor-Pumilio translation repressor complex publication-title: Genes Dev. doi: 10.1101/gad.1119403 contributor: fullname: Edwards – volume: 11 start-page: 1655 year: 2005 ident: key 20170720163656_B46 article-title: Yeast Puf3 mutants reveal the complexity of Puf-RNA binding and identify a loop required for regulation of mRNA decay publication-title: RNA doi: 10.1261/rna.2168505 contributor: fullname: Houshmandi – volume: 144 start-page: 967 year: 1996 ident: key 20170720163656_B35 article-title: Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth publication-title: Genetics doi: 10.1093/genetics/144.3.967 contributor: fullname: Liu – volume: 158 start-page: 187 year: 2001 ident: key 20170720163656_B25 article-title: Multiple functional interactions between components of the Lsm2-Lsm8 complex, U6 snRNA, and the yeast La protein publication-title: Genetics doi: 10.1093/genetics/158.1.187 contributor: fullname: Pannone – volume: 15 start-page: 2852 year: 2001 ident: key 20170720163656_B4 article-title: Hierarchical phosphorylation of the translation inhibitor 4E-BP1 publication-title: Genes Dev. doi: 10.1101/gad.912401 contributor: fullname: Gingras – volume: 6 start-page: 69 year: 2004 ident: key 20170720163656_B30 article-title: Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis publication-title: Dev. Cell doi: 10.1016/S1534-5807(03)00400-3 contributor: fullname: Nakamura – volume: 24 start-page: 8695 year: 2004 ident: key 20170720163656_B41 article-title: Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2282-04.2004 contributor: fullname: Mee – volume: 20 start-page: 3558 year: 2000 ident: key 20170720163656_B3 article-title: Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.20.10.3558-3567.2000 contributor: fullname: Mothe-Satney – volume: 18 start-page: 150 year: 2002 ident: key 20170720163656_B40 article-title: A PUF family portrait: 3′UTR regulation as a way of life publication-title: Trends Genet. doi: 10.1016/S0168-9525(01)02616-6 contributor: fullname: Wickens – volume: 18 start-page: 1452 year: 2004 ident: key 20170720163656_B44 article-title: A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization publication-title: Genes Dev. doi: 10.1101/gad.1189004 contributor: fullname: Gu – volume: 23 start-page: 1559 year: 2009 ident: key 20170720163656_B15 article-title: The SESA network links duplication of the yeast centrosome with the protein translation machinery publication-title: Genes Dev. doi: 10.1101/gad.524209 contributor: fullname: Sezen – volume: 20 start-page: 4423 year: 2001 ident: key 20170720163656_B24 article-title: Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4 publication-title: EMBO J. doi: 10.1093/emboj/20.16.4423 contributor: fullname: Jager – volume: 6 start-page: e255 year: 2008 ident: key 20170720163656_B39 article-title: Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0060255 contributor: fullname: Hogan – start-page: 507 volume-title: Translational Control in Biology and Medicine year: 2007 ident: key 20170720163656_B5 article-title: Translational control in development contributor: fullname: Thompson – volume: 11 start-page: 2522 year: 1997 ident: key 20170720163656_B13 article-title: Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast publication-title: Genes Dev. doi: 10.1101/gad.11.19.2522 contributor: fullname: Polymenis – volume: 24 start-page: 3089 year: 2004 ident: key 20170720163656_B26 article-title: Autonomous function of the amino-terminal inhibitory domain of TAF1 in transcriptional regulation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.8.3089-3099.2004 contributor: fullname: Takahata – volume: 100 start-page: 11429 year: 2003 ident: key 20170720163656_B31 article-title: Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.2033246100 contributor: fullname: Shepard – volume: 20 start-page: 4604 year: 2000 ident: key 20170720163656_B7 article-title: Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.20.13.4604-4613.2000 contributor: fullname: Cosentino – volume: 282 start-page: 15430 year: 2007 ident: key 20170720163656_B48 article-title: Two yeast PUF proteins negatively regulate a single mRNA publication-title: J. Biol. Chem. doi: 10.1074/jbc.M611253200 contributor: fullname: Hook – volume: 17 start-page: 1164 year: 2006 ident: key 20170720163656_B11 article-title: Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E05-11-1039 contributor: fullname: Meier – volume: 21 start-page: 947 year: 2004 ident: key 20170720163656_B20 article-title: A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes publication-title: Yeast doi: 10.1002/yea.1142 contributor: fullname: Janke – volume: 26 start-page: 795 year: 2007 ident: key 20170720163656_B32 article-title: Local activation of yeast ASH1 mRNA translation through phosphorylation of Khd1p by the casein kinase Yck1p publication-title: Mol. Cell doi: 10.1016/j.molcel.2007.05.016 contributor: fullname: Paquin – volume: 23 start-page: 1075 year: 2006 ident: key 20170720163656_B10 article-title: Regulation of translation initiation by the yeast eIF4E binding proteins is required for the pseudohyphal response publication-title: Yeast doi: 10.1002/yea.1415 contributor: fullname: Ibrahimo – volume: 5 start-page: 2120 year: 2006 ident: key 20170720163656_B34 article-title: Identification of translational regulation target genes during filamentous growth in Saccharomyces cerevisiae: regulatory role of Caf20 and Dhh1 publication-title: Eukaryot. Cell doi: 10.1128/EC.00121-06 contributor: fullname: Park – volume: 433 start-page: 477 year: 2005 ident: key 20170720163656_B2 article-title: Regulation of cap-dependent translation by eIF4E inhibitory proteins publication-title: Nature doi: 10.1038/nature03205 contributor: fullname: Richter – volume: 94 start-page: 5201 year: 1997 ident: key 20170720163656_B8 article-title: The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.94.10.5201 contributor: fullname: de la Cruz – volume: 340 start-page: 135 year: 1999 ident: key 20170720163656_B14 article-title: CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E publication-title: Biochem. J. doi: 10.1042/bj3400135 contributor: fullname: Danaie – volume: 25 start-page: 9340 year: 2005 ident: key 20170720163656_B21 article-title: Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.25.21.9340-9349.2005 contributor: fullname: Smirnova – volume: 16 start-page: 1217 year: 2010 ident: key 20170720163656_B49 article-title: Translational repression by PUF proteins in vitro publication-title: RNA doi: 10.1261/rna.2070110 contributor: fullname: Chritton – volume: 10 start-page: 1039 year: 2003 ident: key 20170720163656_B29 article-title: Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock publication-title: Nat. Struct. Biol. doi: 10.1038/nsb1015 contributor: fullname: Preiss – volume: 13 start-page: 6102 year: 1993 ident: key 20170720163656_B28 article-title: PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.13.10.6102 contributor: fullname: Anderson |
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Snippet | eIF4E-binding proteins (4E-BPs) regulate translation of mRNAs in eukaryotes. However the extent to which specific mRNA targets are regulated by 4E-BPs remains... |
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SubjectTerms | Amino Acids - metabolism Cyclins - genetics Eukaryotic Initiation Factors - genetics Eukaryotic Initiation Factors - physiology Gene Deletion Gene Expression Regulation, Fungal Gene Regulation, Chromatin and Epigenetics Nitrogen - metabolism Oligonucleotide Array Sequence Analysis Protein Biosynthesis RNA, Messenger - metabolism RNA-Binding Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - physiology Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic |
Title | Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins |
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