Role of Activated Renin-Angiotensin System in Myocardial Fibrosis and Left Ventricular Diastolic Dysfunction in Diabetic Patients Reversal by Chronic Angiotensin II Type 1A Receptor Blockade

• Published in: Circulation Journal Vol. 71; no. 4; pp. 524 - 529
• Main Authors: Kawasaki, Daizo, Kosugi, Keisuke, Waki, Hidehiko, Yamamoto, Kazuhiro, Tsujino, Takeshi, Masuyama, Tohru
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 2007
• Subjects: Aged; Angiotensin II Type 1 Receptor Blockers - pharmacology; Angiotensin II Type 1 Receptor Blockers - therapeutic use; Angiotensin II type 1A receptor blockade; Benzimidazoles - pharmacology; Benzimidazoles - therapeutic use; Blood Pressure - drug effects; Blood Pressure - physiology; Collagen; Collagen - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diastolic dysfunction; Endomyocardial Fibrosis - drug therapy; Endomyocardial Fibrosis - physiopathology; Female; Humans; Hypertension - physiopathology; Male; Middle Aged; Natriuretic Peptide, Brain - blood; Receptor, Angiotensin, Type 1 - drug effects; Renin-Angiotensin System - drug effects; Renin-Angiotensin System - physiology; Tetrazoles - pharmacology; Tetrazoles - therapeutic use; Ventricular Dysfunction, Left - drug therapy; Ventricular Dysfunction, Left - physiopathology

Background We attempted to test the hypothesis that chronic angiotensin II type 1A receptor blockade (ARB) alters myocardial collagen turnover leading to an improvement of diastolic dysfunction in diabetic patients. Methods and Results Forty-eight type 2 diabetic patients were divided into 2 groups:...