The influence of osteoporotic fractures on health-related quality of life in community-dwelling men and women across Canada

• Published in: Osteoporosis international Vol. 12; no. 11; pp. 903 - 908
• Main Authors: ADACHI, J. D, IOANNIDIS, G, HANLEY, D. A, OLSZYNSKI, W. P, ANASTASSIADES, T, BROWN, J. P, MURRAY, T, JACKSON, S. A, TENENHOUSE, A, BERGER, C, JOSEPH, L, PAPAIOANNOU, A, PICKARD, L, PAPADIMITROPOULOS, E. A, HOPMAN, W, POLIQUIN, S, PRIOR, J. C
• Format: Journal Article
• Language: English
• Published: London Springer 01.11.2001; Springer Nature B.V
• Subjects: Aged; Biological and medical sciences; Canada; Cross-Sectional Studies; Diseases of the osteoarticular system; Drug use; Female; Fractures; Fractures, Bone - etiology; Health Status; Hip Fractures - etiology; Households; Humans; Male; Medical sciences; Medicine; Middle Aged; Multivariate Analysis; Osteoporosis; Osteoporosis - complications; Osteoporosis. Osteomalacia. Paget disease; Pelvic Bones - injuries; Quality of Life; Questionnaires; Regression Analysis; Rib Fractures - etiology; Spinal Fractures - etiology; Womens health; Wrist Injuries - etiology; Canada; North America; America; Montreal Quebec Canada; Calgary Alberta Canada; Toronto Ontario Canada; Quebec Canada; Human; Evaluation; Prevalence; Spine; Diseases of the osteoarticular system; Psychometrics; Bone disease; Fracture; Spine disease; Pelvis bone; Trauma; Epidemiology; Quality of life; Osteoporosis; Symptomatology; Treatment; Pelvis pathology; Adult; Complication; Community health; Upper limb; Bone; Elderly; Public health
• DOI: 10.1007/s001980170017
• ISSN: 0937-941X

Health-related quality of life (HRQL) was examined in relation to prevalent fractures in 4816 community-dwelling Canadian men and women 50 years and older participating in the Canadian Multicentre Osteoporosis Study (CaMos). Fractures were of three categories: clinically recognized main fractures, subclinical vertebral fractures and fractures at other sites. Main fractures were divided and analyzed at the hip, spine, wrist/forearm, pelvis and rib sites. Baseline assessments of anthropometric data, medical history, therapeutic drug use, spinal radiographs and prevalent fractures were obtained from all participants. The SF-36 instrument was used as a tool to measure HRQL. A total of 652 (13.5%) main fractures were reported. Results indicated that hip, spine, wrist/forearm, pelvis and rib fractures had occurred in 78 (1.6%), 40 (0.8%), 390 (8.1%), 19 (0.4%) and 125 (2.6%) individuals, respectively (subjects may have had more than one main fracture). Subjects who had experienced a main prevalent fracture had lower HRQL scores compared with non-fractured participants. The largest differences were observed in the physical functioning (-4.0; 95% confidence intervals (CI): -6.0, -2.0) and role-physical functioning domains (-5.8; 95% CI: -9.5, -2.2). In women, the physical functioning domain was most influenced by hip (-14.9%; 95% CI: -20.9, -9.0) and pelvis (-18.1; 95% CI: -27.6, -8.6) fractures. In men, the role-physical domain was most affected by hip fractures (-35.7; 95% CI: -60.4, -11.1). Subjects who experienced subclinical vertebral fractures had lower HRQL scores than those without prevalent fractures. In conclusion, HRQL was lower in the physical functioning domain in women and the role-physical domain in men who sustained main fractures at the hip. Subclinical vertebral fractures exerted a moderate effect on HRQL.