Chronic pain in patients with the hypermobility type of Ehlers–Danlos syndrome: evidence for generalized hyperalgesia

• Published in: Clinical rheumatology Vol. 34; no. 6; pp. 1121 - 1129
• Main Authors: Rombaut, Lies, Scheper, Mark, De Wandele, Inge, De Vries, Janneke, Meeus, Mira, Malfait, Fransiska, Engelbert, Raoul, Calders, Patrick
• Format: Journal Article
• Language: English
• Published: London Springer London 01.06.2015; Springer Nature B.V
• Subjects: Adult; Case-Control Studies; Central Nervous System Sensitization; Chronic Pain - complications; Chronic Pain - physiopathology; Cognition; Ehlers-Danlos Syndrome - complications; Ehlers-Danlos Syndrome - physiopathology; Fatigue; Female; Health Status; Humans; Hyperalgesia - complications; Hyperalgesia - physiopathology; Medicine; Medicine & Public Health; Middle Aged; Neuralgia - complications; Neuralgia - physiopathology; Original Article; Pain Threshold; Pressure; Rheumatology; Central sensitization; Ehlers–Danlos syndrome; Pain; Joint hypermobility; Pressure pain thresholds; Hyperalgesia

Chronic widespread pain is highly present in patients with the Ehlers–Danlos syndrome hypermobility type (EDS-HT), but up to now, evidence for generalized hyperalgesia is lacking. The aim of this study is to investigate whether pressure pain thresholds (PPTs) at both symptomatic and asymptomatic bod...