Protein Kinase A and Phosphodiesterase-4D3 Binding to Coding Polymorphisms of Cardiac Muscle Anchoring Protein (mAKAP)

• Published in: Journal of molecular biology Vol. 425; no. 18; pp. 3277 - 3288
• Main Authors: Rababa'h, Abeer, Craft, John W., Wijaya, Cori S., Atrooz, Fatin, Fan, Qiying, Singh, Sonal, Guillory, Ashley N., Katsonis, Panagiotis, Lichtarge, Olivier, McConnell, Bradley K.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 23.09.2013
• Subjects: A Kinase Anchor Proteins - chemistry; A Kinase Anchor Proteins - genetics; A Kinase Anchor Proteins - metabolism; Amino Acid Substitution - physiology; Animals; binding sites; Binding Sites - genetics; calcium; cAMP-dependent protein kinase; CHO Cells; correlation; Cricetinae; Cricetulus; Cyclic AMP-Dependent Protein Kinases - metabolism; Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism; HEK293 Cells; Humans; hypertrophy; immunoprecipitation; mutation; myocardium; Myocardium - enzymology; PDE4D3; phosphorylation; Phosphorylation - genetics; Polymorphism, Single Nucleotide - physiology; precipitin tests; protein binding; Protein Binding - genetics; Protein Interaction Domains and Motifs - genetics; Protein Interaction Domains and Motifs - physiology; proteins; sarcoplasmic reticulum; surface plasmon resonance; Western blotting; β-adrenergic receptor; β-AR; RU; hypertrophy; AKAP; CHO; PDE4D3; PDE; CREB; GRK2; SPR; surface plasmon resonance; immunoprecipitation; mAKAP; NCBI; WT; RyR2; IBMX; PKA; PP2A; HEK; ET; NFATc; β-adrenergic receptor; PP2B; UCSC; HF; National Center for Biotechnology Information; evolutionary trace; protein phosphatase 2B, calcineurin; cAMP-response element binding; 3-isobutyl-1-methylxanthine; University of California Santa Cruz; human embryonic kidney; protein phosphatase 2A; protein kinase A; heart failure; muscle-selective A-kinase anchoring protein; nuclear factor of activated T cells; beta-adrenergic receptor; Chinese hamster ovary; G-protein coupled receptor kinase 2; A-kinase anchoring protein; response unit; wild type; phosphodiesterase; ryanodine receptors; phosphodiesterase-4D3

Protein kinase A (PKA) substrate phosphorylation is facilitated through its co-localization with its signaling partner by A-kinase anchoring proteins (AKAPs). mAKAP (muscle-selective AKAP) localizes PKA and its substrates such as phosphodiesterase-4D3 (PDE4D3), ryanodine receptor, and protein phosph...