A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults

• Published in: eLife Vol. 7
• Main Authors: Mai, Nguyen T H, Dobbs, Nicholas, Phu, Nguyen Hoan, Colas, Romain A, Thao, Le T P, Thuong, Nguyen T T, Nghia, Ho D T, Hanh, Nguyen H H, Hang, Nguyen T, Heemskerk, A Dorothee, Day, Jeremy N, Ly, Lucy, Thu, Do D A, Merson, Laura, Kestelyn, Evelyne, Wolbers, Marcel, Geskus, Ronald, Summers, David, Chau, Nguyen V V, Dalli, Jesmond, Thwaites, Guy E
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 27.02.2018; eLife Sciences Publications, Ltd
• Subjects: Adult; Antitubercular Agents - administration & dosage; Antitubercular Agents - adverse effects; Aspirin; Aspirin - administration & dosage; Aspirin - adverse effects; Cerebral infarction; Cerebrospinal fluid; Chemotherapy; clinical trial; Combined Modality Therapy - adverse effects; Combined Modality Therapy - methods; Dexamethasone; Discriminant analysis; Double-Blind Method; Double-blind studies; Drug dosages; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; Female; Fibrinolytic Agents - administration & dosage; Fibrinolytic Agents - adverse effects; HIV; HIV Infections - complications; Human immunodeficiency virus; Humans; infarction; Inflammation; Intestine; Lipids; Magnetic resonance imaging; Male; Meningitis; Mental Disorders - epidemiology; Mental Disorders - prevention & control; Microbiology and Infectious Disease; Middle Aged; Mortality; Mycobacterium tuberculosis; Neuroimaging; NMR; Nuclear magnetic resonance; Placebos - administration & dosage; Software; Survival Analysis; Thrombosis; Thromboxane A2; Treatment Outcome; Tuberculosis; Tuberculosis, Meningeal - drug therapy; tuberculous meningitis; Ho Chi Minh City Vietnam; United Kingdom > UK; Vietnam; clinical trial; Mycobacterium tuberculosis; infectious disease; tuberculous meningitis; infarction; microbiology; aspirin; human

Adjunctive dexamethasone reduces mortality from tuberculous meningitis (TBM) but not disability, which is associated with brain infarction. We hypothesised that aspirin prevents TBM-related brain infarction through its anti-thrombotic, anti-inflammatory, and pro-resolution properties. We conducted a...