An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1
Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4)-induced tyrosine phosphorylation by direct interaction with coactivators. The CREB-binding protein and the nuclear coactivator 1 (NCoA-1), a member of the p160/steroid...
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Published in | The Journal of biological chemistry Vol. 277; no. 39; pp. 36052 - 36060 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
27.09.2002
American Society for Biochemistry and Molecular Biology |
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Abstract | Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4)-induced tyrosine phosphorylation by direct interaction with coactivators. The CREB-binding protein and the nuclear coactivator 1 (NCoA-1), a member of the p160/steroid receptor coactivator family, bind independently to specific regions of STAT6 and act as coactivators. In this study we show that an LXXLL motif in the STAT6 transactivation domain mediates the interaction with NCoA-1. Peptides representing this motif as well as antibodies generated against this motif inhibited STAT6/NCoA-1 interaction in glutathione S-transferase pulldown assays. Peptides derived from the STAT6 transactivation domain adjacent to the LXXLL motif as well as antibodies against these peptides showed no inhibitory effect. Mutagenesis of the LXXLL motif eliminated the STAT6/NCoA-1 interaction in vitro and in vivo, supporting the specific role of this motif in NCoA-1 binding. Importantly, mutagenesis of the STAT-LXXLL motif strongly diminished the IL-4-regulated activation of the endogenous STAT6 target gene eotaxin-3. Taken together, these results indicate that the STAT6-LXXLL-binding motif mediates the interaction with NCoA-1 in transcriptional activation and represents a new potential drug target for the inhibition of the STAT6 transactivation function in allergic diseases. |
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AbstractList | Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4)-induced tyrosine phosphorylation by direct interaction with coactivators. The CREB-binding protein and the nuclear coactivator 1 (NCoA-1), a member of the p160/steroid receptor coactivator family, bind independently to specific regions of STAT6 and act as coactivators. In this study we show that an LXXLL motif in the STAT6 transactivation domain mediates the interaction with NCoA-1. Peptides representing this motif as well as antibodies generated against this motif inhibited STAT6/NCoA-1 interaction in glutathione S-transferase pulldown assays. Peptides derived from the STAT6 transactivation domain adjacent to the LXXLL motif as well as antibodies against these peptides showed no inhibitory effect. Mutagenesis of the LXXLL motif eliminated the STAT6/NCoA-1 interaction in vitro and in vivo, supporting the specific role of this motif in NCoA-1 binding. Importantly, mutagenesis of the STAT-LXXLL motif strongly diminished the IL-4-regulated activation of the endogenous STAT6 target gene eotaxin-3. Taken together, these results indicate that the STAT6-LXXLL-binding motif mediates the interaction with NCoA-1 in transcriptional activation and represents a new potential drug target for the inhibition of the STAT6 transactivation function in allergic diseases. Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4)-induced tyrosine phosphorylation by direct interaction with coactivators. The CREB-binding protein and the nuclear coactivator 1 (NCoA-1), a member of the p160/steroid receptor coactivator family, bind independently to specific regions of STAT6 and act as coactivators. In this study we show that an L XX LL motif in the STAT6 transactivation domain mediates the interaction with NCoA-1. Peptides representing this motif as well as antibodies generated against this motif inhibited STAT6/NCoA-1 interaction in glutathione S -transferase pulldown assays. Peptides derived from the STAT6 transactivation domain adjacent to the L XX LL motif as well as antibodies against these peptides showed no inhibitory effect. Mutagenesis of the L XX LL motif eliminated the STAT6/NCoA-1 interaction in vitro and in vivo , supporting the specific role of this motif in NCoA-1 binding. Importantly, mutagenesis of the STAT-L XX LL motif strongly diminished the IL-4-regulated activation of the endogenous STAT6 target gene eotaxin-3. Taken together, these results indicate that the STAT6-L XX LL-binding motif mediates the interaction with NCoA-1 in transcriptional activation and represents a new potential drug target for the inhibition of the STAT6 transactivation function in allergic diseases. |
Author | Litterst, Claudia M. Pfitzner, Edith |
Author_xml | – sequence: 1 givenname: Claudia M. surname: Litterst fullname: Litterst, Claudia M. – sequence: 2 givenname: Edith surname: Pfitzner fullname: Pfitzner, Edith email: e.pfitzner@em.uni-frankfurt.de |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12138096$$D View this record in MEDLINE/PubMed |
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Snippet | Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4)-induced tyrosine... Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4)-induced tyrosine... |
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SubjectTerms | Amino Acid Motifs Amino Acid Sequence Cell Line Chemokine CCL26 Chemokines, CC - metabolism Enzyme-Linked Immunosorbent Assay Escherichia coli - metabolism Genes, Reporter Glutathione Transferase - metabolism Histone Acetyltransferases Humans Luciferases - metabolism Molecular Sequence Data Mutagenesis, Site-Directed Mutation Nuclear Receptor Coactivator 1 Peptides - chemistry Plasmids - metabolism Point Mutation Precipitin Tests Protein Binding Protein Structure, Tertiary Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid STAT6 Transcription Factor Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - chemistry Transcription Factors - metabolism Transcriptional Activation Transfection |
Title | An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1 |
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