PEP-1-p18 prevents neuronal cell death by inhibiting oxidative stress and Bax expression

• Published in: BMB reports Vol. 45; no. 9; pp. 532 - 537
• Main Authors: Kim, D.S., Soonchunhyang University, Cheonan, Republic of Korea, Sohn, E.J., Hallym University, Chuncheon, Republic of Korea, Kim, D.W., Hallym University, Chuncheon, Republic of Korea, Kim, Y.N., Hallym University, Chuncheon, Republic of Korea, Eom, S.A., Hallym University, Chuncheon, Republic of Korea, Yoon, G.H., Hallym University, Chuncheon, Republic of Korea, Cho, S.W., University of Ulsan College of Medicine, Seoul, Republic of Korea, Lee, S.H., Hallym University, Chuncheon, Republic of Korea, Hwang, H.S., Hallym University, Chuncheon, Republic of Korea, Cho, Y.S., Hallym University, Chuncheon, Republic of Korea, Park, J.S., Hallym University, Chuncheon, Republic of Korea, Eum, W.S., Hallym University, Chuncheon, Republic of Korea, Choi, S.Y., Hallym University, Chuncheon, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society for Biochemistry and Molecular Biology 01.09.2012; 생화학분자생물학회
• Subjects: Animals; Apoptosis; bcl-2-Associated X Protein - metabolism; Cell Line; Cell viability; Cysteamine - analogs & derivatives; Cysteamine - pharmacology; Disease Models, Animal; DNA Fragmentation - drug effects; Dopaminergic Neurons - cytology; Dopaminergic Neurons - metabolism; Genetic Vectors - genetics; Genetic Vectors - metabolism; Humans; Mice; MPTP Poisoning; Oxidative Stress - drug effects; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; PEP-1-p18; Peptides - pharmacology; Protein therapy; Protein transduction; PROTEINAS; PROTEINE; PROTEINS; 화학

P18, a member of the INK4 family of cyclin-dependent kinase inhibitors, is a tumor suppressor protein and plays a key cell survival role in a variety of human cancers. Under pathophysiological conditions, the INK4 group proteins participate in novel biological functions associated with neuronal dise...